DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Flacc and Thoc2l

DIOPT Version :9

Sequence 1:	NP_573339.1	Gene:	Flacc / 32886	FlyBaseID:	FBgn0030974	Length:	1150	Species:	Drosophila melanogaster
Sequence 2:	NP_001160053.1	Gene:	Thoc2l / 100042165	MGIID:	3040669	Length:	1589	Species:	Mus musculus

Alignment Length:	568	Identity:	108/568 - (19%)
Similarity:	208/568 - (36%)	Gaps:	163/568 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 KRDKRDHVQKKLVAKRNHIKRKLKEARLKKRAAAALS----GHVHRSLSPTTR-----AKLKKLA 168
            |.|:.|:...:.|..:.|.|       |.|.:...|.    .|:...|...|:     .|:..|.
Mouse  1084 KADQLDYENFRHVVHKWHYK-------LTKASVHCLETGEYTHIRNILIVLTKILPWYPKVLNLG 1141

  Fly   169 E--RKRLRAASKEQRERD--------------KLRVVQRDRERDHHRLGSSRSPPSSSTTTTTKI 217
            :  .:|:....:|::|:.              |.|......|.:.|.    :.||..:|.|..
Mouse  1142 QALERRVHKICQEEKEKKPDLYALAMVYSGQLKSRKSYMIPENEFHH----KDPPPRNTATNL-- 1200

  Fly   218 RIHQDIVGKRQKSP--GLGSGLGGGSSSSSSRMHHQLMSREKIIIQTRARGRTPSLE-------- 272
                     :...|  ||.|.:|.......|.......|||:.....:|..:..|:.
Mouse  1201 ---------QPSGPCSGLPSSIGSMCKLDESSAEEADKSRERAQCAVKAANKASSVTPKGNLSNG 1256

  Fly   273 ---------RERERERERERERERERHDLSLRERDR---RDRERERAEREAARDKERAEALARCQ 325
                     :|.::|:.:|:|:|::....::....|   :|.:.:..|.:..:|::..||..|..
Mouse  1257 NSGSNSKAVKENDKEKGKEKEKEKKEKTPAVTPEARVLGKDSKEKPKEEQPNKDEKIREAKERMP 1321

  Fly   326 ERQRERERLAREKLRRQEE-------------EEGGKRGGPGRDLDL----------------PP 361
            :..:::|:|.:|:..:.|:             :|..|...|.::.||                |.
Mouse  1322 KSDKDKEKLKKEEKAKDEKFRIIVANVESKSTQEREKEKEPSKERDLAKEMKSKENVKGGEKAPV 1386

  Fly   362 YGSRERSL---DTVERERERERSGRHVRDKRELDPYEREQEYLEERHGHGLIDEMRRYRRRDLSP 423
            .||.:..:   |..|.|||:         :|::|.:.      ...|...:.|.:.:.:......
Mouse  1387 SGSLKSPISRTDITEPEREK---------RRKVDSHP------SPSHSSTIKDSLVKLKESSAKL 1436

  Fly   424 MPEHYAP-------RLRDPRELYSEEERERAYKRAYLDAR--------YSSREREAWLEARELRE 473
            ...|..|       |..|.::|  ::.|||:.:|...:.:        ||:.:|||.|:..:.|:
Mouse  1437 YINHIPPLLCKSKEREADKKDL--DKSRERSREREKKEEKDRKERKRDYSNNDREAPLDLIKRRK 1499

  Fly   474 RE---LQGREYRDLETEDTLYPDERERLIRDRERDRERERDRERERNIGPRGD-FRPEWEREWEE 534
            .|   |...:::.....::|||:|     :|:|:.:.:...:|       :|| |:||   :.::
Mouse  1500 DENGILGVSKHKSESPCESLYPNE-----KDKEKMKSKSSGKE-------KGDSFKPE---KIDK 1549

  Fly   535 EGAGGGPGGPSGTPGRPGGFVGGPKRGKPPAHAGGGPPSQQQHHSASE 582
            ..:|....|..           ..|..|.....|.|...:::||..|:
Mouse  1550 ISSGKKESGHD-----------KEKIEKKEKWDGSGDKEEKKHHKTSD 1586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Flacc	NP_573339.1	None
Thoc2l	NP_001160053.1	THOC2_N	13..566	CDD:406523
		Thoc2	568..642	CDD:403051
		Tho2	874..1173	CDD:402722	17/95 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1874
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900