DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp39 and usp39

DIOPT Version :9

Sequence 1:	NP_573334.1	Gene:	Usp39 / 32881	FlyBaseID:	FBgn0030969	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001073539.1	Gene:	usp39 / 790924	ZFINID:	ZDB-GENE-030131-966	Length:	497	Species:	Danio rerio

Alignment Length:	476	Identity:	303/476 - (63%)
Similarity:	368/476 - (77%)	Gaps:	12/476 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 EEDETPS---------VFNPKYRVCPYLDTINRNLLDFDFEKLCSISLTRINVYACLVCGKYFQG 78
            :|||...         |.:.:.|.|||||||||::|||||||||||||:.|||||||:|||||||
Zfish    12 DEDEEEEVRVKVGRGYVEDRRSRHCPYLDTINRSVLDFDFEKLCSISLSHINVYACLICGKYFQG 76

  Fly    79 RGTNTHAYTHSVGEAHHVFLNLHTLRFYCLPDNYEIIDSSLDDIKYVLNPTFTRQEISKLDQLQP 143
            ||..:|||.|||..|||||||||||:|||||||||||||||:||.|||.||||:|.||.||: |.
Zfish    77 RGQKSHAYIHSVQVAHHVFLNLHTLKFYCLPDNYEIIDSSLEDITYVLKPTFTKQHISGLDK-QG 140

  Fly   144 KHSRTVDGVLYLPGVVGLNNIKANDYCNVVLHALSHVGPLRDYFLQKQSYAHVVRPPGDSVFTLV 208
            |..|..||..||||:|||||||||||.||||.|||:|.|||:|||::::|..:.|||||.:|.||
Zfish   141 KLYRAYDGTTYLPGIVGLNNIKANDYANVVLQALSNVPPLRNYFLEEENYRGIRRPPGDIMFLLV 205

  Fly   209 QRFGELMRKMWNPRNFKSHVSPHEMLQAVVLWSSKRFQITEQGDPIDFLSWFLNTLHRALKGNKH 273
            |||||||||:|||||||:|||||||||||||.|.|.||||:|||.:||||||||.||.||.|.|
Zfish   206 QRFGELMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDAVDFLSWFLNALHGALGGTK- 269

  Fly   274 PNSSILYKIFLGEMKIYTRKMPPVELDDAAKAQLLATEEYKDQVEDKNFIYLTCDLPPPPLFTDE 338
            ..|||:.|.|.|.|:|:::|:|..:|....|..||..|||::::.:..|:|||.|||..||:.||
Zfish   270 KKSSIITKAFQGSMRIFSKKLPHPDLPPEEKEALLLKEEYQEEMSESTFLYLTLDLPTAPLYKDE 334

  Fly   339 FRENIIPQVNLYQLLSKFNGTAEKEYKTYKANFMKRFEITRLPQFIILYIKRFTKNTFFLEKNPT 403
            ..:.|||||.|:.:|.||||..||||||||.||:|||::|:||.::|..|||||||.||:|||||
Zfish   335 KEQLIIPQVPLFNILGKFNGNTEKEYKTYKENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPT 399

  Fly   404 IVNFPIKHVDFGDILGMRQRDKDVKDTKYNLVANIVHDGDPKKGTYRAHILHKANGQWYEMQDLH 468
            ||||||.:||..:.| ..:.....|:|.|:||||:||||.|.:|:||.|:||...|:|||:|||.
Zfish   400 IVNFPITNVDLREYL-TEEAQVTEKNTTYDLVANVVHDGKPTEGSYRIHVLHHGTGKWYELQDLQ 463

  Fly   469 VTEILPQMITLTESYIQIYER 489
            |.:||||||||:|:||||::|
Zfish   464 VIDILPQMITLSEAYIQIWKR 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp39	NP_573334.1	Peptidase_C19M	39..488	CDD:239134	296/448 (66%)
Usp39	NP_573334.1	UCH	158..487	CDD:278850	203/328 (62%)
usp39	NP_001073539.1	Peptidase_C19M	37..483	CDD:239134	296/448 (66%)
usp39	NP_001073539.1	UCH	155..482	CDD:278850	203/328 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575691
Domainoid	1	1.000	420	1.000	Domainoid score	I620
eggNOG	1	0.900	-	-		E1_KOG2026
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13183
Inparanoid	1	1.050	618	1.000	Inparanoid score	I860
OMA	1	1.010	-	-		QHG54751
OrthoDB	1	1.010	-	-		D219856at33208
OrthoFinder	1	1.000	-	-		FOG0003552
OrthoInspector	1	1.000	-	-		oto41605
orthoMCL	1	0.900	-	-		OOG6_102786
Panther	1	1.100	-	-	LDO	PTHR21646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1590
SonicParanoid	1	1.000	-	-		X2428
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800