DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp39 and Usp39

DIOPT Version :9

Sequence 1:	NP_573334.1	Gene:	Usp39 / 32881	FlyBaseID:	FBgn0030969	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_006506279.1	Gene:	Usp39 / 28035	MGIID:	107622	Length:	573	Species:	Mus musculus

Alignment Length:	512	Identity:	308/512 - (60%)
Similarity:	379/512 - (74%)	Gaps:	34/512 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PAAKRMKLEKTPANPV---------EEDETP-----------SVFNPKYRVCPYLDTINRNLLDF 51
            |||:.:   ..||.||         :||..|           ...:.:.|.|||||||||::|||
Mouse    56 PAAREV---PAPALPVVRVKREREADEDSEPEREVRAKNGRVDSEDRRSRHCPYLDTINRSVLDF 117

  Fly    52 DFEKLCSISLTRINVYACLVCGKYFQGRGTNTHAYTHSVGEAHHVFLNLHTLRFYCLPDNYEIID 116
            ||||||||||:.||.||||||||||||||..:|||.|||..:||||||||||:||||||||||||
Mouse   118 DFEKLCSISLSHINAYACLVCGKYFQGRGLKSHAYIHSVQFSHHVFLNLHTLKFYCLPDNYEIID 182

  Fly   117 SSLDDIKYVLNPTFTRQEISKLDQLQPKHSRTVDGVLYLPGVVGLNNIKANDYCNVVLHALSHVG 181
            |||:||.|||.||||:|:|:.||: |.|.||..||..||||:|||||||||||.|.||.|||:|.
Mouse   183 SSLEDITYVLKPTFTKQQIANLDK-QAKLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVP 246

  Fly   182 PLRDYFLQKQSYAHVVRPPGDSVFTLVQRFGELMRKMWNPRNFKSHVSPHEMLQAVVLWSSKRFQ 246
            |||:|||::.:|.::.|||||.:|.|||||||||||:|||||||:|||||||||||||.|.|.||
Mouse   247 PLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQ 311

  Fly   247 ITEQGDPIDFLSWFLNTLHRALKGNKHPNSSILYKIFLGEMKIYTRKMPPVELDDAAKAQLLATE 311
            ||:|||.:||||||||.||.||.|.|....:|:..:|.|.|:|:|:|:|..:|....|.|||..:
Mouse   312 ITKQGDGVDFLSWFLNALHSALGGTKKKKKTIVNDVFQGSMRIFTKKLPHPDLPAEEKEQLLHND 376

  Fly   312 EYKDQVEDKNFIYLTCDLPPPPLFTDEFRENIIPQVNLYQLLSKFNGTAEKEYKTYKANFMKRFE 376
            ||::.:.:..|:|||.|||..||:.||..:.|||||.|:.:|:||||..||||||||.||:|||:
Mouse   377 EYQETMVESTFMYLTLDLPTAPLYKDEKEQLIIPQVPLFNILAKFNGITEKEYKTYKENFLKRFQ 441

  Fly   377 ITRLPQFIILYIKRFTKNTFFLEKNPTIVNFPIKHVDFGDILGMRQRDKDV----KDTKYNLVAN 437
            :|:||.::|..|||||||.||:|||||||||||.:||..:.|     .::|    |:|.|:|:||
Mouse   442 LTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYL-----SEEVQAVHKNTTYDLIAN 501

  Fly   438 IVHDGDPKKGTYRAHILHKANGQWYEMQDLHVTEILPQMITLTESYIQIYERCPNSS 494
            |||||.|.:|:||.|:||...|:|||:|||.||:||||||||:|:|||: .||...|
Mouse   502 IVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQV-ARCGRHS 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp39	NP_573334.1	Peptidase_C19M	39..488	CDD:239134	293/452 (65%)
Usp39	NP_573334.1	UCH	158..487	CDD:278850	202/332 (61%)
Usp39	XP_006506279.1	PRK04537	<3..93	CDD:235307	16/56 (29%)
Usp39	XP_006506279.1	Peptidase_C19M	105..550	CDD:239134	281/443 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832980
Domainoid	1	1.000	421	1.000	Domainoid score	I638
eggNOG	1	0.900	-	-		E1_KOG2026
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13183
Inparanoid	1	1.050	620	1.000	Inparanoid score	I877
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54751
OrthoDB	1	1.010	-	-		D219856at33208
OrthoFinder	1	1.000	-	-		FOG0003552
OrthoInspector	1	1.000	-	-		oto93127
orthoMCL	1	0.900	-	-		OOG6_102786
Panther	1	1.100	-	-	LDO	PTHR21646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1590
SonicParanoid	1	1.000	-	-		X2428
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800