DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp39 and ubp10

DIOPT Version :9

Sequence 1:	NP_573334.1	Gene:	Usp39 / 32881	FlyBaseID:	FBgn0030969	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_595305.1	Gene:	ubp10 / 2540864	PomBaseID:	SPBC577.07	Length:	502	Species:	Schizosaccharomyces pombe

Alignment Length:	499	Identity:	227/499 - (45%)
Similarity:	308/499 - (61%)	Gaps:	42/499 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KRMKLE---------KTPANPVEEDETPSVFNPKYRVCPYLDTINRNLLDFDFEKLCSISLTRIN 65
            ||.|||         ...:..:||.||..:.:...    |||||||.||||||||:||:|||.::
pombe    25 KRKKLELGKDMEDVHDIASKEMEEHETTPIISQNL----YLDTINRKLLDFDFEKVCSVSLTNLS 85

  Fly    66 VYACLVCGKYFQGRGTNTHAYTHSVGEAHHVFLNLHTLRFYCLPDNYEIIDSSLDDIKYVLNPTF 130
            ||||||||:||||||.::|||.|::.|.||||:|..||:||.||::|::..|:|.||.||:.|||
pombe    86 VYACLVCGRYFQGRGPSSHAYFHALTENHHVFVNCSTLKFYVLPESYQVESSALQDIAYVMRPTF 150

  Fly   131 TRQEISKLDQLQPKHSRTVDGVLYLPGVVGLNNIKANDYCNVVLHALSHVGPLRDYFLQKQSYAH 195
            |:.|:.:||. .|:.|..:....|:||.||:||||.|||.|||:|.|:||.|.|:|||.|..
pombe   151 TKLEVQRLDH-TPQLSYDLMLKPYVPGFVGMNNIKNNDYFNVVIHMLAHVKPFRNYFLLKNF--- 211

  Fly   196 VVRPPGDSVFTLVQRFGELMRKMWNPRNFKSHVSPHEMLQAVVLWSSKRFQITEQGDPIDFLSWF 260
                  |:...||||...|:||:||.:.|||||||.|::|.|.:.|.|::.|.||.||::|||||
pombe   212 ------DNCPQLVQRLAILIRKLWNHKAFKSHVSPQELIQEVTVLSHKKYSINEQKDPVEFLSWF 270

  Fly   261 LNTLHRALKGNK----HPNSSILYKIFLGEMKIYTRKMPPVELDDAAKA-QLLATEEYKDQVEDK 320
            |||||..|.|.|    .|.|.:.|. |.|.::|.::|:    ...|.|. |::.|.:...|....
pombe   271 LNTLHNCLGGKKSTIAKPTSIVHYS-FQGFVRIESQKI----RQHAEKGEQVVFTGDRVIQTNVV 330

  Fly   321 NFIYLTCDLPPPPLFTDEFRENIIPQVNLYQLLSKFNGTAEKEYKTYKANFMKRFEITRLPQFII 385
            .|:|||.||||.|:|.|||..||||||.|.::|:|:||...:|.    |...:||.:...|.:.|
pombe   331 PFLYLTLDLPPKPIFQDEFEGNIIPQVELKEILNKYNGVHTQEL----AGMRRRFHLMTAPPYFI 391

  Fly   386 LYIKRFTKNTFFLEKNPTIVNFPIKHVDFGDILGMRQRDKDVK-DTKYNLVANIVHD----GDPK 445
            .:||||.||.:|.|:|.|||.||:...|....:.......:.| .|||||||||:|:    .:.:
pombe   392 FHIKRFMKNNYFTERNQTIVTFPLDDFDMSPFIDDSFIQSNPKISTKYNLVANIIHESVTHAEEE 456

  Fly   446 KGTYRAHILHKANGQWYEMQDLHVTEILPQMITLTESYIQIYER 489
            ...:|..|.:.:..:||::|||:|.||...||.|.||:||::||
pombe   457 FHNFRIQIRNPSTNKWYQIQDLYVEEISSDMIRLGESFIQLWER 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp39	NP_573334.1	Peptidase_C19M	39..488	CDD:239134	216/458 (47%)
Usp39	NP_573334.1	UCH	158..487	CDD:278850	147/338 (43%)
ubp10	NP_595305.1	Peptidase_C19M	59..499	CDD:239134	216/462 (47%)
ubp10	NP_595305.1	UCH	178..489	CDD:278850	141/328 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	243	1.000	Domainoid score	I442
eggNOG	1	0.900	-	-		E1_KOG2026
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13183
Inparanoid	1	1.050	406	1.000	Inparanoid score	I370
OMA	1	1.010	-	-		QHG54751
OrthoFinder	1	1.000	-	-		FOG0003552
OrthoInspector	1	1.000	-	-		oto101052
orthoMCL	1	0.900	-	-		OOG6_102786
Panther	1	1.100	-	-	LDO	PTHR21646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1590
SonicParanoid	1	1.000	-	-		X2428
TreeFam	1	0.960	-	-
	14	13.860