DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp39 and USP39

DIOPT Version :9

Sequence 1:	NP_573334.1	Gene:	Usp39 / 32881	FlyBaseID:	FBgn0030969	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001243654.1	Gene:	USP39 / 10713	HGNCID:	20071	Length:	565	Species:	Homo sapiens

Alignment Length:	507	Identity:	308/507 - (60%)
Similarity:	382/507 - (75%)	Gaps:	29/507 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QAPAA----KRMKLEKTPANPVEEDETP-----------SVFNPKYRVCPYLDTINRNLLDFDFE 54
            :|||:    .|:|.|:    .|:||..|           ...:.:.|.|||||||||::||||||
Human    61 EAPASVVPFVRVKRER----EVDEDSEPEREVRAKNGRVDSEDRRSRHCPYLDTINRSVLDFDFE 121

  Fly    55 KLCSISLTRINVYACLVCGKYFQGRGTNTHAYTHSVGEAHHVFLNLHTLRFYCLPDNYEIIDSSL 119
            |||||||:.||.||||||||||||||..:|||.|||..:||||||||||:|||||||||||||||
Human   122 KLCSISLSHINAYACLVCGKYFQGRGLKSHAYIHSVQFSHHVFLNLHTLKFYCLPDNYEIIDSSL 186

  Fly   120 DDIKYVLNPTFTRQEISKLDQLQPKHSRTVDGVLYLPGVVGLNNIKANDYCNVVLHALSHVGPLR 184
            :||.|||.||||:|:|:.||: |.|.||..||..||||:|||||||||||.|.||.|||:|.|||
Human   187 EDITYVLKPTFTKQQIANLDK-QAKLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLR 250

  Fly   185 DYFLQKQSYAHVVRPPGDSVFTLVQRFGELMRKMWNPRNFKSHVSPHEMLQAVVLWSSKRFQITE 249
            :|||::.:|.::.|||||.:|.|||||||||||:|||||||:|||||||||||||.|.|.||||:
Human   251 NYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITK 315

  Fly   250 QGDPIDFLSWFLNTLHRALKGNKHPNSSILYKIFLGEMKIYTRKMPPVELDDAAKAQLLATEEYK 314
            |||.:||||||||.||.||.|.|....:|:..:|.|.|:|:|:|:|..:|....|.|||..:||:
Human   316 QGDGVDFLSWFLNALHSALGGTKKKKKTIVTDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQ 380

  Fly   315 DQVEDKNFIYLTCDLPPPPLFTDEFRENIIPQVNLYQLLSKFNGTAEKEYKTYKANFMKRFEITR 379
            :.:.:..|:|||.|||..||:.||..:.|||||.|:.:|:||||..||||||||.||:|||::|:
Human   381 ETMVESTFMYLTLDLPTAPLYKDEKEQLIIPQVPLFNILAKFNGITEKEYKTYKENFLKRFQLTK 445

  Fly   380 LPQFIILYIKRFTKNTFFLEKNPTIVNFPIKHVDFGDILGMRQRDKDV----KDTKYNLVANIVH 440
            ||.::|..|||||||.||:|||||||||||.:||..:.|     .::|    |:|.|:|:|||||
Human   446 LPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYL-----SEEVQAVHKNTTYDLIANIVH 505

  Fly   441 DGDPKKGTYRAHILHKANGQWYEMQDLHVTEILPQMITLTESYIQIYERCPN 492
            ||.|.:|:||.|:||...|:|||:|||.||:||||||||:|:||||::|..|
Human   506 DGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRDN 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp39	NP_573334.1	Peptidase_C19M	39..488	CDD:239134	294/452 (65%)
Usp39	NP_573334.1	UCH	158..487	CDD:278850	202/332 (61%)
USP39	NP_001243654.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..61		308/507 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..95		5/23 (22%)
		Peptidase_C19M	106..553	CDD:239134	294/452 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142856
Domainoid	1	1.000	421	1.000	Domainoid score	I632
eggNOG	1	0.900	-	-		E1_KOG2026
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13183
Inparanoid	1	1.050	621	1.000	Inparanoid score	I883
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54751
OrthoDB	1	1.010	-	-		D219856at33208
OrthoFinder	1	1.000	-	-		FOG0003552
OrthoInspector	1	1.000	-	-		oto89560
orthoMCL	1	0.900	-	-		OOG6_102786
Panther	1	1.100	-	-	LDO	PTHR21646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1590
SonicParanoid	1	1.000	-	-		X2428
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800