DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shop and SUOX

DIOPT Version :9

Sequence 1:	NP_573331.1	Gene:	shop / 32878	FlyBaseID:	FBgn0030966	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	XP_016875394.1	Gene:	SUOX / 6821	HGNCID:	11460	Length:	552	Species:	Homo sapiens

Alignment Length:	468	Identity:	244/468 - (52%)
Similarity:	320/468 - (68%)	Gaps:	15/468 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 YRAEEVEQHNSVEKRIWVTYGLGVYDVTDFVENHPGG-DKILMAAGSAIDPFWGIYQQHNTLEVL 174
            |..|||..|.|.|..||||.|..|:|||:||:.|||| .|:::|||..::|||.:|..||...|.
Human    92 YTKEEVSSHTSPETGIWVTLGSEVFDVTEFVDLHPGGPSKLMLAAGGPLEPFWALYAVHNQSHVR 156

  Fly   175 ELLEGFRIGNL--EGLVVTNVDDELGSPWSQEPQRHALLKPASKRPFNAEPPIGLLAEQFYTPNE 237
            |||..::||.|  |..|...|  |...|::.:|.||..||..|:||||||||..||.|.:.|||.
Human   157 ELLAQYKIGELNPEDKVAPTV--ETSDPYADDPVRHPALKVNSQRPFNAEPPPELLTENYITPNP 219

  Fly   238 LFYVRNHLPVPVINPEDYELEIEG--GAKDKTLTLDGIKALPKHSVTAAIMCGGNRRSEMTKVKA 300
            :|:.|||||||.::|:.|.|.:.|  |.:..:|:||.:...|::.:|..:.|.||||||||:||.
Human   220 IFFTRNHLPVPNLDPDTYRLHVVGAPGGQSLSLSLDDLHNFPRYEITVTLQCAGNRRSEMTQVKE 284

  Fly   301 VKGLSWGAGAVGNAKWSGARLCDILREQGVQPDETK-HVIFEGADLDPTSHPYGASIPLAKALDP 364
            ||||.|..||:..|:|:||||||:|.:.|.|..||: ||.|||.|.|||...||||||||:|:||
Human   285 VKGLEWRTGAISTARWAGARLCDVLAQAGHQLCETEAHVCFEGLDSDPTGTAYGASIPLARAMDP 349

  Fly   365 RGDVILAYEMNDEPLSRDHGFPIRVIVPGTVGARNVKWLTRIVVADKESDSHWQQNDYKGFSPST 429
            ..:|:||||||.:||.||||||:||:|||.||||:||||.|:.|..:||.||||:.||||||||.
Human   350 EAEVLLAYEMNGQPLPRDHGFPVRVVVPGVVGARHVKWLGRVSVQPEESYSHWQRRDYKGFSPSV 414

  Fly   430 DWDTVDFSKSDAIQAMPVTSAICTPQPGARVKVDDDEGHITVRGYAWSGGGRKIVRVDLTNDEGV 494
            ||:||||..:.:||.:||.|||..|:.|..|    :.|.:|::|||||||||.::|||::.|.|:
Human   415 DWETVDFDSAPSIQELPVQSAITEPRDGETV----ESGEVTIKGYAWSGGGRAVIRVDVSLDGGL 475

  Fly   495 SWHVAELEQEEMPDGRHYGWSLWTARLPVSEAQRRAGDVEIWAKAVDSAYNVQPEKFEHIWNLRG 559
            :|.||:|:.||....:.:.|.||..:.||...|:   ::.|..||||..|||||:....||||||
Human   476 TWQVAKLDGEEQRPRKAWAWRLWQLKAPVPAGQK---ELNIVCKAVDDGYNVQPDTVAPIWNLRG 537

  Fly   560 VLANAYHKVKVKI 572
            ||:||:|:|.|.:
Human   538 VLSNAWHRVHVYV 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shop	NP_573331.1	Cyt-b5	110..185	CDD:278597	38/74 (51%)
		PLN00177	199..572	CDD:177772	201/375 (54%)
		eukary_SO_Moco	211..572	CDD:239029	197/363 (54%)
SUOX	XP_016875394.1	Cyt-b5	93..167	CDD:306642	37/73 (51%)
SUOX	XP_016875394.1	eukary_SO_Moco	192..550	CDD:239029	197/364 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2687
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H394
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1377
Isobase	1	0.950	-	0	Normalized mean entropy	S2171
OMA	1	1.010	-	-		QHG63137
OrthoDB	1	1.010	-	-		D288655at33208
OrthoFinder	1	1.000	-	-		FOG0004792
OrthoInspector	1	1.000	-	-		oto88884
orthoMCL	1	0.900	-	-		OOG6_100179
Panther	1	1.100	-	-	LDO	PTHR19372
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4400
SonicParanoid	1	1.000	-	-		X3942
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.920