DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htk and Arid4b

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	NP_919238.1	Gene:	Arid4b / 94246	MGIID:	2137512	Length:	1314	Species:	Mus musculus

Alignment Length:	1445	Identity:	392/1445 - (27%)
Similarity:	594/1445 - (41%)	Gaps:	359/1445 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQQMDDPPSLPVGTEVSAKYKGAFCEAKVSKVVRNIKVKVAYKQGLGSGIVSDDAIKAPTGQLRV 65
            |:.:|:||.|.|||:|||||:|||||||:....|.:||||.::....:..|.||.||.|   |:|
Mouse     1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGP---LKV 62

  Fly    66 GAVVEVRHPDRKELVEATITKIQDCSQYTVVFDDGDITTLRRTALCLKSGRHFNESETLDQLPLT 130
            ||:|||::.| ....||.|.|:.|.|.|||||||||..||||::||||..|||.|||||||||||
Mouse    63 GAIVEVKNLD-GAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLT 126

  Fly   131 HPEHFGNPVVGGR--RGRRRGHLNED----SSEDDDESDAKEVVNEKEENIGKVVCVETESKKKD 189
            :|||||.||:|.:  ||||..|:.|:    ||.||||.:.|:.    :|.:||||||:..|.:|.
Mouse   127 NPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEEERKQT----DELLGKVVCVDYVSLEKK 187

  Fly   190 KEKWFPALVVAPTAQATVRIRVKDEYLVRSFKDGRYYTVPKKEATEFTREVASKQDVPAVQA--- 251
            |..|||||||.|.....:.:: ||..||||||||::.:||:|:..|.|.:...|.|....||
Mouse   188 KAMWFPALVVCPDCSDEIAVK-KDNILVRSFKDGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQ 251

  Fly   252 ALEFLDSSVLPAHWDRDSLFGLTNISSDDEGEIDSDSSDDEPH----------------EEKDRF 300
            ||||..|..:||:|..:    |...||..|.|.:.:..|||..                ||::.|
Mouse   252 ALEFHKSRAIPANWKTE----LKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENF 312

  Fly   301 VAQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPCTVS 365
            :.||||:|:|||||:||.|.:..|:::|::|||.|.|.||::.:.|...||.:...||     :.
Mouse   313 LQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLG-----IP 372

  Fly   366 VMNL-----VKQAYKKFLQPYGDFHR--KLGCSMLMTSRNSNRSKGRSLVRANSVASPKPMETMK 423
            |:|.     ||.||||:|..:.::.|  .:...|.:..:..|                ||.:..:
Mouse   373 VLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLN----------------KPCKDCE 421

  Fly   424 TETISKLAQPNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEESGNTSESSVVVEPPKKQ 488
            .:.: |:.:.::|.:                          .:...|:|.|...........:.:
Mouse   422 NKEV-KVKEESETEI--------------------------KEVNVEDSKNVMPKEETPAEDESE 459

  Fly   489 RKGSAASSQQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTATNLSSATS 553
            ||.:...| .|..|||:|                           .:|..|
Mouse   460 RKENIKPS-LGSKKSLLE---------------------------CIPAQS-------------- 482

  Fly   554 GGSATIATTAMNKDAESDLPLAKIKAAAVAAASTRHSMEKETNISSGSSASA-SSKANSAEMQRS 617
                         |.|.:..:.|              :|:..|:.......| :.:|.|.|:...
Mouse   483 -------------DEEKEAHITK--------------LEENENLEDKDGGRARTEEAFSTEVDGE 520

  Fly   618 RDASPSVAAPPSAGASTSGAAATAQTASNKKEKHQRSKQADKEKDKDKEEKQASSGKRKKEKISV 682
            .:.:.|       |..|:            ||:.:..::.::|:::|:||.:........|:...
Mouse   521 EEQARS-------GDETN------------KEEDEDDEEIEEEEEEDEEEDEDEDDDDNNEEEEF 566

  Fly   683 EKIDTGDFVVGIGDKLKVNYHEKKSPSSHGSTYEAKVIEISVQRGVPMYLVHYTGWNNRYDEWVP 747
            |....       |.|::|.|...|:.    ..|||.:.:..|:.|..:|||||.|||.|||||:.
Mouse   567 ECYPP-------GMKVQVRYGRGKNQ----KMYEASIKDSDVEGGEALYLVHYCGWNVRYDEWIK 620

  Fly   748 RERIAENLTKG--------------SKQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGGGSLLV 798
            .::|.....|.              .|:|.|....|..|                      ..|.
Mouse   621 ADKIVRPADKNVPKIKHRKKIKNKLDKEKDRDEKYSPKN----------------------CKLR 663

  Fly   799 QGSQPPGVSDKQPGKDGCSKMSPSSGNSTGPGAPSLSGSLGGASSTPSLLSTVVKTPPTG--GAK 861
            :.|:.|..|:  |..:..||:..:...:               |.|..:.|..:.:...|  .::
Mouse   664 RLSKSPFQSN--PSPEMVSKLDLADAKN---------------SDTAHIKSIEITSILNGLQASE 711

  Fly   862 RGRGRSDSMPPRST-------TPSSVVAHSGRTKSPAASQ-----PQLQQQMKKRPTRVVPGTT- 913
            .....|:....|.|       ...|.|.||..:::...|:     |.|.::.|.....|:..|.
Mouse   712 SSAEDSEQEDERCTQDVDNIGKDESKVEHSTHSRNELISKEEQSSPSLLEENKVHTDLVIAKTVS 776

  Fly   914 -TPRRVSDASMASESDSDSDEPVRRPKRQSAKDKPQAGKAQPP----GKGRLASS---------- 963
             :|.|:.....|...|:|.:|.....|::....|....||..|    ||.|..|:
Mouse   777 KSPERLRKDMEAISEDTDFEEEDEITKKRKDVKKDTTDKALKPQTKRGKRRYCSADECLQTGSPG 841

  Fly   964 -----ASSTAP-AAHPSDDSEEDEEEEEPSAARAASSKQQ---QQQASSLRG-------SRAGGN 1012
                 ..|..| ....|.:|..||:|||.|.|:...:|:.   :::..|||.       |.....
Mouse   842 KKEDRTKSKEPLCTENSSNSSSDEDEEEKSKAKMTPTKKYNGLEEKRKSLRTTSFYSGFSEVAEK 906

  Fly  1013 RAM---SSGAASAKGRDYDLSEIRSELKGFQPKLLTNAASNEERKDLAKKEPSDEPALQDIKKEP 1074
            |..   :|.......|..|..::.|.::|..||.......::...:.|...|  .||..:...|.
Mouse   907 RIKLLNNSDERLQNNRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPP--HPAPDEGAVEE 969

  Fly  1075 KLESSAKSSS----TEL------SSETESYADEDSQSSDYRKQLKGSGAG---KKEPTA--SPSK 1124
            .|::.|:..|    .||      |.:.:...::..:.||.:.:...||:.   ...||.  |||.
Mouse   970 SLQTVAEEESCSPIMELEKPLPASVDNKPIEEKPLEVSDRKTEFPSSGSNSVLNTPPTTPESPSS 1034

  Fly  1125 LHHEPVTKRELAVKEEPLKIEPKTEPKEEETKSKPFLSGADIKPTALIAPAR----FGNTS-AAQ 1184
                 ||..|.:.::..:.:.....|.:||.:|....:.:.|:..:::...:    .||:| |..
Mouse  1035 -----VTITEASQQQSSVTVSVPLPPNQEEVRSIKSETDSTIEVDSVVGELQDLQSEGNSSPAGF 1094

  Fly  1185 AASSSGSSSTTAKYTSVIVEKPLTIGGKKSVEQHVPKKAELLKKQSGGAGGTAASSSAASQESKK 1249
            .||.|.|||...:..:  .||..|  |:|.|            |.:.|.|    |||...:.|.|
Mouse  1095 DASVSSSSSNQPEPDN--PEKACT--GQKRV------------KDTQGVG----SSSKKQKRSHK 1139

  Fly  1250 FAEPVASLKVEMPAACSPSSSSSSSSSFCSTGSAVSSSSATRSLPDMSKLEISSGTVPGATPGAA 1314
             |..|.:.|       ....::||.|...|.|.:|:.:...:|:|...|...|.......:||..
Mouse  1140 -ATVVNNKK-------KGKGTNSSDSEELSAGESVTKTQTIKSVPTGMKTHNSKSPARVQSPGKG 1196

  Fly  1315 A---------LQPSN 1320
            .         .:|||
Mouse  1197 GRNGDKDPDLKEPSN 1211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392	42/93 (45%)
		ARID	299..381	CDD:279697	37/86 (43%)
		Tudor-knot	692..751	CDD:288553	23/58 (40%)
Arid4b	NP_919238.1	TUDOR	58..113	CDD:197660	32/58 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..169		25/45 (56%)
		RBB1NT	168..263	CDD:369729	42/99 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..306		8/43 (19%)
		ARID_ARID4B	308..399	CDD:350647	38/95 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..577		35/232 (15%)
		CD_CSD	573..630	CDD:391946	23/60 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	635..678		10/66 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..888		40/178 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..1215		70/304 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1256..1290
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848697
Domainoid	1	1.000	180	1.000	Domainoid score	I3492
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	447	1.000	Inparanoid score	I1616
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003167
OrthoInspector	1	1.000	-	-		otm43501
orthoMCL	1	0.900	-	-		OOG6_106607
Panther	1	1.100	-	-	O	PTHR13964
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	1	1.000	-	-		X2560
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.870