DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htk and ARID5B

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	NP_115575.1	Gene:	ARID5B / 84159	HGNCID:	17362	Length:	1188	Species:	Homo sapiens

Alignment Length:	1241	Identity:	233/1241 - (18%)
Similarity:	390/1241 - (31%)	Gaps:	421/1241 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 GDITTLRRT---ALCL---------KSGRHFNESETLDQLPLTHPEHFGNPVVGGRRGRRRGHLN 152
            ||...:|.|   .:|:         ::.|....|..|..||...|:           ||     |
Human    39 GDFFFVRCTPKDPICIAELQLLWEERTSRQLLSSSKLYFLPEDTPQ-----------GR-----N 87

  Fly   153 EDSSEDDDESDAKEVVNEKEE-------NIGKVVC------VETESKKKDKEKWFPALVVAPTAQ 204
            .|..||:..:.:::|:.:.|:       :..|..|      |:||:..::.:|  .||:....:.
Human    88 SDHGEDEVIAVSEKVIVKLEDLVKWVHSDFSKWRCGFHAGPVKTEALGRNGQK--EALLKYRQST 150

  Fly   205 ATVRIRVKD---------------EYLVRSFKD-GRYYTVPK----KEATEFTRE---------V 240
            ....:..||               ..:|.|:.. .||.::.|    |.::..|.:         |
Human   151 LNSGLNFKDVLKEKADLGEDEEETNVIVLSYPQYCRYRSMLKRIQDKPSSILTDQFALALGGIAV 215

  Fly   241 ASKQDVPAVQAALEFLDSSVL----------------------PAHWDRDSLFGLTNISSDDEG- 282
            .|:.  |.:....:..|...|                      |....|||..|:.:.:::.:|
Human   216 VSRN--PQILYCRDTFDHPTLIENESICDEFAPNLKGRPRKKKPCPQRRDSFSGVKDSNNNSDGK 278

  Fly   283 -----EIDSDSSDDEP----------HEEKDR-------------FVAQLYKYMDDRGTPLNKVP 319
                 :.::.|:..:|          :|||.:             |:..|||||.:|.||:.::|
Human   279 AVAKVKCEARSALTKPKNNHNCKKVSNEEKPKVAIGEECRADEQAFLVALYKYMKERKTPIERIP 343

  Fly   320 SILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPCTVSVMNLVKQAYKKFLQPYGDF 384
            .:..:.::|:.:|:|.||.|||..:|::.|||.|...||..|.:.|.....::.|::.:.||..|
Human   344 YLGFKQINLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERF 408

  Fly   385 HRKLGCSMLMTSRNSNRSKGRSLVRANSVASPKPMETMKTETISKLAQPNQTNVVASTSS----- 444
                             .||.         ..||:..:|.......:|.|:.....|.:.
Human   409 -----------------IKGE---------EDKPLPPIKPRKQENSSQENENKTKVSGTKRIKHE 447

  Fly   445 -SAAAASVAASSTPARAVSTASQSAAEESGNTSESSVVVEPPKKQRKGSAASSQQGKVKSLVEKY 508
             ..:......:..|..|...:|:...|:....|:.|:....|....|......|:...|.|..:.
Human   448 IPKSKKEKENAPKPQDAAEVSSEQEKEQETLISQKSIPEPLPAADMKKKIEGYQEFSAKPLASRV 512

  Fly   509 E-EKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTATNLSSATSGGSATIATTAMNKDAESDL 572
            : ||.......|:.......|.......|..||
Human   513 DPEKDNETDQGSNSEKVAEEAGEKGPTPPLPSA-------------------------------- 545

  Fly   573 PLAKIKAAAVAAASTRHSMEKETNISSGSSASASSKANS--AEMQRSRDASPSVAAPPSAGASTS 635
            |||..|.:|:...:::..:       :..||...||..|  .....|.::.|..|:.||...:..
Human   546 PLAPEKDSALVPGASKQPL-------TSPSALVDSKQESKLCCFTESPESEPQEASFPSFPTTQP 603

  Fly   636 GAAATAQTASNK--------------------KEKHQRSKQA---------DKEKDKDKEEKQAS 671
            ..|...:|..:|                    .:.|...||.         |..||||.
Human   604 PLANQNETEDDKLPAMADYIANCTVKVDQLGSDDIHNALKQTPKVLVVQSFDMFKDKDL------ 662

  Fly   672 SGKRKKEKISVEKIDTGDFVVGIGDKLKVNYHEKKSPSSHGSTYEAKVIEISVQRGVPMYLVHYT 736
                           ||..                 ..:||..|    ..:...||.|
Human   663 ---------------TGPM-----------------NENHGLNY----TPLLYSRGNP------- 684

  Fly   737 GWNNRYDEWVPRERIAENLTKGSKQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGGGSLLVQGS 801
                         .|...|.|  |:....:|.:|.:|.                      ...||
Human   685 -------------GIMSPLAK--KKLLSQVSGASLSSS----------------------YPYGS 712

  Fly   802 QPPGVSDKQ--PGKDGCSKMSPS-SGNSTGPGA---PSLSGSLGGASSTPS----LLSTVVKTPP 856
            .||.:|.|:  ...|.||.:|.: .|.||...|   ||:...:....|.||    .::.:.|
Human   713 PPPLISKKKLIARDDLCSSLSQTHHGQSTDHMAVSRPSVIQHVQSFRSKPSEERKTINDIFK--- 774

  Fly   857 TGGAKRGRGRSDSMPPRSTTPSSVVAHSGRTKSPAASQPQLQQQM-----KKRPTRVVPGTTTPR 916
                .....|||  |.|       .:.|....:|.|....|:|::     |....|.:|.:..|.
Human   775 ----HEKLSRSD--PHR-------CSFSKHHLNPLADSYVLKQEIQEGKDKLLEKRALPHSHMPS 826

  Fly   917 RVSDASMAS-------------ESDSDSDEPVRRPKRQSAKDKPQAGKAQPPGKGRLASSA---- 964
            .::|...:.             .::..|..|.|...|:|......:.:.|........:|.
Human   827 FLADFYSSPHLHSLYRHTEHHLHNEQTSKYPSRDMYRESENSSFPSHRHQEKLHVNYLTSLHLQD 891

  Fly   965 SSTAPAAHPSDDSEED----EEEEEPSA-----ARAASSKQQQQQASSLR--GSR---------- 1008
            ..:|.|..|:||...|    :...:|:.     |.:.:..|:.:..|..:  ||:
Human   892 KKSAAAEAPTDDQPTDLSLPKNPHKPTGKVLGLAHSTTGPQESKGISQFQVLGSQSRDCHPKACR 956

  Fly  1009 ------AGGNRAMSSGAASAKGRDYDLSEIRSELKGFQPKLLTNAASNEERKDLAKKEPSDEPAL 1067
                  :|..:...|.:.|.|.....|...| :::|....:|..           |..|.:..|.
Human   957 VSPMTMSGPKKYPESLSRSGKPHHVRLENFR-KMEGMVHPILHR-----------KMSPQNIGAA 1009

  Fly  1068 QDIKKE----------------PKLESSAKSSSTELSSETESYADEDSQSSDYRKQLKGSGAGKK 1116
            :.||:.                ..|:.|.:.|..|.:||.||   |.|::: :.....|...|.|
Human  1010 RPIKRSLEDLDLVIAGKKARAVSPLDPSKEVSGKEKASEQES---EGSKAA-HGGHSGGGSEGHK 1070

  Fly  1117 EPTASP 1122
            .|.:||
Human  1071 LPLSSP 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392	23/154 (15%)
		ARID	299..381	CDD:279697	28/94 (30%)
		Tudor-knot	692..751	CDD:288553	6/58 (10%)
ARID5B	NP_115575.1	BAH	34..>108	CDD:295389	18/84 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..277		5/25 (20%)
		BRIGHT	319..411	CDD:128777	31/108 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..611		40/246 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	846..874		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..918		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	956..978		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1028..1070		12/45 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158301
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.770