DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htk and arid3b

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	XP_005163185.1	Gene:	arid3b / 571249	ZFINID:	ZDB-GENE-070209-182	Length:	616	Species:	Danio rerio

Alignment Length:	563	Identity:	127/563 - (22%)
Similarity:	199/563 - (35%)	Gaps:	159/563 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 RGHLNEDSSEDDDESDAKEVVNEKEENIG-------------KVVCVETESKKKDKEKWFPALVV 199
            ||..:|...:||||....|..:|:||:.|             ..|.|...|        ||....
Zfish   135 RGRGSEGDEDDDDEMMDGEDGSEEEESEGLEFLRKQSLALQQAAVGVPPYS--------FPVYTA 191

  Fly   200 APTA----QATVRIRVKDEYLVRSFKDGRYYTVPKKEATEFTREVASKQDVPAVQAALEFLDSSV 260
            :|:|    ..:...:|||| ...|..|.:.:..|..
Zfish   192 SPSAAKKRPLSPTTKVKDE-PEDSLSDQQSFNTPNG----------------------------- 226

  Fly   261 LPAHWDRDSLFGLTNISSDDE--------GEIDSDSS-----DDEPHEEKDRFVAQLYKYMDDRG 312
             ...|:.|..|.....||.:|        ||...|.:     |::|  ::..|:..|:.||..||
Zfish   227 -MGDWNLDDSFKQNGNSSWNEEGDGGRSRGEASRDFAKLYELDNDP--KRKEFLDDLFAYMQKRG 288

  Fly   313 TPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPCTVSVMNLVKQAYKKF 377
            ||:|::|.:..:.:|||.|::.|.::||...|.::..|:.|...|.......|....::..|.|:
Zfish   289 TPVNRIPIMAKQVLDLYMLYKLVTEKGGLVEVINKKIWREITKGLNLPTSITSAAFTLRTQYMKY 353

  Fly   378 LQPYGDFHRKLGCSM---LMTSRNSNRSKGR------SLVR--------ANSVASPKPMETMKTE 425
            |.||.  ..|.|.|.   |..:.:|||.:||      ||.|        |..:.||..|....|.
Zfish   354 LYPYE--CEKKGLSSPGELQAAIDSNRREGRRPGYSNSLYRFSPSPSGAAPHLLSPPKMHLPATG 416

  Fly   426 TISKLAQPNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEE--------------SGNTS 476
            .....|.|:.....|:....:.|:.:.|....|.|:....|.|...              :|..:
Zfish   417 HNELQATPSPALKKATVPEDSPASMLPARLPLALALGHQQQLARAATLEQLRERLETGMGAGAVN 481

  Fly   477 ESSVVVEPPKKQRKGSAASSQQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAA 541
            ....|||.|::            |:..|.|  |::....||.....:|     .::...||....
Zfish   482 AGPAVVEGPER------------KMARLAE--EQQRLLQQAFQQNLLA-----MASQVNPTNLRM 527

  Fly   542 ASTAT-----NLS-SATSGGSATIATT----------AMNKDAESDLPLAKIKAAAVAAASTRHS 590
            .:..|     :|| |.:|.|||:|..:          ::.......:|      .||.|....|:
Zfish   528 NNANTREEKQDLSLSISSNGSASITVSVEVNGIIYSGSLYAQKSGSVP------TAVTAMFPGHT 586

  Fly   591 MEKETNISSGSSASASSKANSAEMQRSRDASPSVAAPPSAGAS 633
            ......::|.||:|:|...:|.:              |:.|.|
Zfish   587 STLSPGVASSSSSSSSKGPDSVD--------------PATGGS 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392	17/107 (16%)
		ARID	299..381	CDD:279697	25/81 (31%)
		Tudor-knot	692..751	CDD:288553
arid3b	XP_005163185.1	BRIGHT	271..363	CDD:128777	29/95 (31%)
arid3b	XP_005163185.1	DUF4251	<523..566	CDD:290766	10/42 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940