DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htk and Arid3b

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	NP_001366282.1	Gene:	Arid3b / 56380	MGIID:	1930768	Length:	568	Species:	Mus musculus

Alignment Length:	615	Identity:	132/615 - (21%)
Similarity:	226/615 - (36%)	Gaps:	169/615 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 KSGRHFNESETL---------DQLPLTHPEHFGNPVVGG----------RRGRRRGHLNEDSSE- 157
            |.|....||:.|         ..|.:|.....|:.|:|.          .|...:.::|.:..|
Mouse    28 KQGPQTRESQFLYASKLGTQPALLSITPGRPSGSSVLGPLARVPPATPVARMSEQSNVNSEPEEE 92

  Fly   158 ------DDDESDAKEVVNEKEENIGKVVCVETESKKKDK----EKWFPALVVAPTAQATVRIRVK 212
                  :|.:.|..||..::.:...|...::..::::.:    ....|...::|..|.|.....|
Mouse    93 EGGLEDEDGDDDVAEVAEKEAQAASKYFHMQKVTRQEPRATPMSSLLPVPGLSPQGQQTKEDHTK 157

  Fly   213 DEYLVRSFKDGRYYTVPKKEATEFTREVASKQDVPAVQAALEFLDSSVLPAHWDRDSLF---GLT 274
            |                           |||.. |:|..|.:       |: |..|...   |..
Mouse   158 D---------------------------ASKAP-PSVPTAGQ-------PS-WSLDEQLKQNGAL 186

  Fly   275 NISSDDEG----EIDSDSS-----DDEPHEEKDRFVAQLYKYMDDRGTPLNKVPSILSRDVDLYR 330
            ..|.|.:|    ||..|.:     |.:|  |:..|:..|:.:|..||||:|::|.:..:.:|||.
Mouse   187 AWSDDADGGRGREISRDFAKLYELDGDP--ERKEFLDDLFIFMQKRGTPINRIPIMAKQILDLYM 249

  Fly   331 LFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPCTVSVMNLVKQAYKKFLQPYGDFHRKLGC-SMLM 394
            |::.|.::||...:.::..|:.|...|.......|....::..|.|:|..|....:.|.. :.|.
Mouse   250 LYKLVTEKGGLVEIINKKIWREITKGLNLPTSITSAAFTLRTQYMKYLYAYECEKKALSSPAELQ 314

  Fly   395 TSRNSNRSKGRSLVRANSVASPKPMETMKTETISKLAQPNQTNVVASTSSSAAAASVAASSTPAR 459
            .:.:.||.:||....::|:....|...                ..|:.:::|||||.|::.|||.
Mouse   315 AAIDGNRREGRRPSYSSSLFGYSPAAA----------------AAAAAAAAAAAASAASAGTPAL 363

  Fly   460 AVSTA---SQSAAEESGNTSESSVVVEPPKKQRKGSA-------------------ASSQQGKVK 502
            ..|..   |......|..||.||..:.|....|||..                   |.::.|.::
Mouse   364 LSSPKIRFSILGLGSSSGTSASSPRIPPASTLRKGDGVPVPVPNRLAVSGTLAGQQAGNRPGPLE 428

  Fly   503 SLVEKY------EEKSTAVQATSSGTVAGS---GASASAAAMP---------TTSAAASTATNLS 549
            .|.|:.      |:|::.:.......|..:   ...:.|..:|         ..:..::.|.||:
Mouse   429 HLRERLESGEPPEKKASRLSEEEQRLVQQAFQRNLFSMARQLPMKIRINGREDRAEPSAPALNLT 493

  Fly   550 SATSGGSATIATTAMNKDAESD------LPLAKIKAAAVAAASTRHSMEKETNISSGSSASASSK 608
            ::..|        ::|...:.|      :..|:.....:.|.||..|:        |||||:|:.
Mouse   494 TSNIG--------SINMSVDIDGTTYTGVLFAQKPVVHLIAGSTPQSI--------GSSASSSNS 542

  Fly   609 ANSAEMQRSRDASPSVAA---PPSAGASTS 635
            ::|       ..|||..:   .|||..|||
Mouse   543 SSS-------HCSPSPTSSRGTPSAEPSTS 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392	13/94 (14%)
		ARID	299..381	CDD:279697	23/81 (28%)
		Tudor-knot	692..751	CDD:288553
Arid3b	NP_001366282.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..174		31/181 (17%)
		Interaction with RB1. /evidence=ECO:0000250	201..374		48/190 (25%)
		ARID_ARID3B	202..327	CDD:350643	34/126 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..403		9/24 (38%)
		Interaction with ARID3A. /evidence=ECO:0000250	495..518		3/30 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..568		18/52 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840