DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htk and Arid3c

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	NP_001017362.1	Gene:	Arid3c / 550619	MGIID:	3650624	Length:	409	Species:	Mus musculus

Alignment Length:	440	Identity:	101/440 - (22%)
Similarity:	151/440 - (34%)	Gaps:	124/440 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 QLPLTHPEHFGNPVVGGRRGRRRGHLNEDSSEDDDESDAKEVVNEKEENIGKVVCVETESKKKDK 190
            :|||..|     |::|.|                       .:...|..|| ||..|.|...:|:
Mouse    23 RLPLPQP-----PLLGAR-----------------------TLQAPEGAIG-VVGAEEEEGAEDE 58

  Fly   191 EKWFPALVVAPTAQATVRIRVKDEYLVRSFKDGRYYTVPKKEATEFTREVASKQDVPAVQAALEF 255
            |...|.              .::|...:|....|....|..::             |.:|
Mouse    59 EGETPL--------------AEEETAEQSHPGARCPNSPSSQS-------------PGIQ----- 91

  Fly   256 LDSSVLPAHWDRDSLFGLTNISSDDEGEIDSDSSDDEPHEEKDRFVAQLYKYMDDRGTPLNKVPS 320
                  |..|..:..|       ....|:|:|       .::..|:..|:.:|..||||:|:||.
Mouse    92 ------PHEWTYEEQF-------KQLYELDAD-------PKRKEFLDDLFSFMQKRGTPVNRVPI 136

  Fly   321 ILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPCTVSVMNLVKQAYKKFLQPYGDFH 385
            :..:.:|||.|||.|..:||...|.::..|:.:...|.......|....::..|.|:|.||....
Mouse   137 MAKQVLDLYALFRLVTAKGGLVEVINRKVWREVTRGLSLPTTITSAAFTLRTQYMKYLYPYECET 201

  Fly   386 RKLGC-SMLMTSRNSNRSKGRSLVRANSVASPKPMETMKTETISKLAQPNQTNVVASTSSSAAAA 449
            |.|.. ..|..:.:|||.:||   |....|.|          :..||.|.........||...|.
Mouse   202 RALSSPGELQAAIDSNRREGR---RQAYTAVP----------LFNLAGPTPRGAPGPASSHGPAP 253

  Fly   450 SV----------AASSTPARAVSTASQSAA--EESG---------------NTSESSVVVEPPKK 487
            :.          :||..||.|.:..|.|..  ||||               .|.|.....|||:|
Mouse   254 TATPNCPGPTQGSASGLPAHACAQLSPSPVKKEESGIPPPRLALPMGLASEATREKLAPEEPPEK 318

  Fly   488 QR--KGSAASSQQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAM 535
            :.  .|...|.:.|...|.:.:.:......:......:||||.|:...|:
Mouse   319 RAVLMGPVDSPRLGAPPSFLPRGKAPLREERLDGPLNLAGSGISSINVAL 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392	16/90 (18%)
		ARID	299..381	CDD:279697	26/81 (32%)
		Tudor-knot	692..751	CDD:288553
Arid3c	NP_001017362.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..91		22/123 (18%)
		BRIGHT	111..202	CDD:128777	28/90 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..274		10/40 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..333		8/26 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..409
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840