DRSC/TRiP Functional Genomics Resources

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Protein Alignment htk and ARID4B

DIOPT Version :10

Sequence 1:NP_573330.3 Gene:htk / 32877 FlyBaseID:FBgn0085451 Length:2486 Species:Drosophila melanogaster
Sequence 2:NP_057458.4 Gene:ARID4B / 51742 HGNCID:15550 Length:1312 Species:Homo sapiens


Alignment Length:1398 Identity:370/1398 - (26%)
Similarity:579/1398 - (41%) Gaps:324/1398 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MQQMDDPPSLPVGTEVSAKYKGAFCEAKVSKVVRNIKVKVAYKQGLGSGIVSDDAIKAPTGQLRV 65
            |:.:|:||.|.|||:|||||:|||||||:....|.:||||.::....:..|.||.||.|   |:|
Human     1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGP---LKV 62

  Fly    66 GAVVEVRHPDRKELVEATITKIQDCSQYTVVFDDGDITTLRRTALCLKSGRHFNESETLDQLPLT 130
            ||:|||::.| ....||.|.|:.|.|.|||||||||..||||::||||..|||.|||||||||||
Human    63 GAIVEVKNLD-GAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLT 126

  Fly   131 HPEHFGNPVVGGR--RGRRRGHLNED----SSEDDDESDAKEVVNEKEENIGKVVCVETESKKKD 189
            :|||||.||:|.:  ||||..|:.|:    ||.|:||.|.|::    :|.:||||||:..|..|.
Human   127 NPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQI----DELLGKVVCVDYISLDKK 187

  Fly   190 KEKWFPALVVAPTAQATVRIRVKDEYLVRSFKDGRYYTVPKKEATEFTREVASKQDVPAVQA--- 251
            |..|||||||.|.....:.:: ||..||||||||::.:||:|:..|.|.:.|.|.|....||   
Human   188 KALWFPALVVCPDCSDEIAVK-KDNILVRSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQ 251

  Fly   252 ALEFLDSSVLPAHWDRDSLFGLTNISSDDEGEIDSDSSDDEPH----------------EEKDRF 300
            ||||..|..:||:|..:    |...||..|.|.:.:..|||..                ||::.|
Human   252 ALEFHKSRTIPANWKTE----LKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENF 312

  Fly   301 VAQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPCTVS 365
            :.||||:|:|||||:||.|.:..|:::|::|||.|.|.||::.:.|...||.:...||     :.
Human   313 LQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLG-----IP 372

  Fly   366 VMNL-----VKQAYKKFLQPYGDFHRKLGCSMLMTSRNSNRSKGRSLVRANSVASPKPMETMKTE 425
            |:|.     ||.||||:|..:.::.|.......|..  ..:...:......:|...|..|..:||
Human   373 VLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMAL--PEKVVNKQCKECENVKEIKVKEENETE 435

  Fly   426 TISKLAQPNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEESGNTSESSVVVEPPKKQRK 490
             |.::....:.|::                                             |:::  
Human   436 -IKEIKMEEERNII---------------------------------------------PREE-- 452

  Fly   491 GSAASSQQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTATNLSSATSGG 555
                       |.:.::.|.|.....:..|                                   
Human   453 -----------KPIEDEIERKENIKPSLGS----------------------------------- 471

  Fly   556 SATIATTAMNKDAESDLPLAKIKAAAVAAASTRHSMEKETNISSGSSASASSKANSAEMQRSR-D 619
                     .|:....:|             |....|||.||.....   :...:..:...:| |
Human   472 ---------KKNLLESIP-------------THSDQEKEVNIKKPED---NENLDDKDDDTTRVD 511

  Fly   620 ASPSVAAPPSAGASTSGAAATAQTASNKKEKHQRSKQADKEKDKDKEEKQASSGKRKKEKISVEK 684
            .|.::........:.||      ..:||:|.....:..::|:::::||.:......::|:..   
Human   512 ESLNIKVEAEEEKAKSG------DETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFE--- 567

  Fly   685 IDTGDFVVGIGDKLKVNYHEKKSPSSHGSTYEAKVIEISVQRGVPMYLVHYTGWNNRYDEWVPRE 749
                  ....|.|::|.|...|:.    ..|||.:.:..|:.|..:|||||.|||.|||||:..:
Human   568 ------CYPPGMKVQVRYGRGKNQ----KMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKAD 622

  Fly   750 RIAENLTKG--------------SKQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGGGSLLVQG 800
            :|.....|.              .|:|.:....|..|                      ..|.:.
Human   623 KIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKN----------------------CKLRRL 665

  Fly   801 SQPPGVSDKQPGKDGCSKMSPSSGNSTGPG---APSLSGSLGGASSTPSLLSTVVKTPPTGGAKR 862
            |:||  ....|..:..||:..:...::...   :..::..|.|..::.|       :......:.
Human   666 SKPP--FQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASES-------SAEDSEQED 721

  Fly   863 GRGRSDSMPPRSTTPSSVVAHSGRTKSPAASQPQ-----LQQQMKKRPTRVV--PGTTTPRRV-S 919
            .||..|.  ..:....|.:.|....::...|:.:     |.::.|.....|:  |.:.:|.|: .
Human   722 ERGAQDM--DNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRK 784

  Fly   920 DASMASESDSDSDEPVRRPKRQSAK-------DKPQ--AGKAQ-----------PPGKGRLASSA 964
            |..:.|| |:|.:|.....||:..|       .|||  .||.:           .||| :...:.
Human   785 DIEVLSE-DTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGK-KEEKAK 847

  Fly   965 SSTAPAAHPSDDSEEDEEEEEPSAARAASSKQQ--QQQASSLR--GSRAGGNRAM--------SS 1017
            :..:.....|.:|..||:|||..|....:.|..  :::..|||  |..:|.:...        :|
Human   848 NKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNS 912

  Fly  1018 GAASAKGRDYDLSEIRSELKGFQPKLLTNAASNEERKDLAKKEPSDEPALQDIKKEPKLESSAKS 1082
            .......|..|..::.|.::|..||.......::...:.|...|  .||.::...|..|::.|:.
Human   913 DERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPP--HPAPEEGVAEESLQTVAEE 975

  Fly  1083 SSTELSSETES----------YADEDSQSSDYRKQLKGSGAG---KKEPTA--SPSKLHHEPVTK 1132
            .|...|.|.|.          ..::..:.:|.:.:...||:.   ...||.  |||.     ||.
Human   976 ESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSS-----VTV 1035

  Fly  1133 RELAVKEEPLKIEPKTEPKEEETKSKPFLSGADIKPTALIAPAR----FGNTSAA---QAASSSG 1190
            .|.:.::..:.:.....|.:||.:|....:.:.|:..::....:    .||:|.|   .:.|||.
Human  1036 TEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSS 1100

  Fly  1191 SSSTTAKYTSVIVEKPLT---------IGGKKSVEQHVPKKAELLKKQSGGAGGTAASSSAASQ- 1245
            |:....::.    ||..|         .||..|.:|....||.::..:..|.|..::.|...|. 
Human  1101 SNQPEPEHP----EKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAG 1161

  Fly  1246 ESKKFAEPVASLKVEMPAACSPSSSSSSSSSFC 1278
            ||...::||.|:...|.:..:.|.:.:.|...|
Human  1162 ESITKSQPVKSVSTGMKSHSTKSPARTQSPGKC 1194

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htkNP_573330.3 Tudor_ARID4_rpt1 10..60 CDD:410460 26/49 (53%)
Tudor_ARID4_rpt2 65..118 CDD:410461 31/52 (60%)
RBB1NT 170..263 CDD:462390 43/95 (45%)
ARID 296..381 CDD:460187 38/89 (43%)
CBD_RBP1_like 698..758 CDD:350843 22/59 (37%)
ARID4BNP_057458.4 Tudor_ARID4B_rpt1 1..61 CDD:410531 31/62 (50%)
Tudor_ARID4B_rpt2 62..118 CDD:410533 34/56 (61%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 124..166 22/41 (54%)
RBB1NT 170..263 CDD:462390 43/93 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 266..306 8/43 (19%)
ARID_ARID4B 308..399 CDD:350647 38/95 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 458..577 25/193 (13%)
Antigenic epitope 465..473 1/51 (2%)
CD_CSD 573..630 CDD:475127 23/60 (38%)
SAS2 583..>681 CDD:227360 30/125 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 635..680 9/68 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 708..894 42/196 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 909..1212 64/297 (22%)
Antigenic epitope 1130..1137 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1252..1288
Blue background indicates that the domain is not in the aligned region.

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