DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htk and arid3a

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	NP_001011106.1	Gene:	arid3a / 496519	XenbaseID:	XB-GENE-945264	Length:	541	Species:	Xenopus tropicalis

Alignment Length:	472	Identity:	108/472 - (22%)
Similarity:	185/472 - (39%)	Gaps:	101/472 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 DSSEDDDESDAKEVVNEKEENIGKVVCVETESKKKD-KEKW----FPALVVAPTAQATVRIRVKD 213
            |..|:|.||.|.:..:|||.:.......:..|:::| |.||    |                 :|
Frog    85 DEEEEDGESMASDEEDEKERDGESERYPDMGSEEEDLKGKWDEDDF-----------------ED 132

  Fly   214 EYLVRSFKD-------------GRYYTVPKKEATEFTREVASKQDVPAVQAALEFLDSSVLPAH- 264
            |.....::|             |:..|:|.|...  .:...:::.|.|.:|.|.......|..|
Frog   133 EGEEDDYEDMEEGMGVSEAGRVGKGSTLPPKHPN--PQAFPTQRSVGAERAGLPHTGHPQLQDHG 195

  Fly   265 -WDRDSLFGLTNISSDDEGEIDSDSSDDEPHEEKDRFVAQLYKYMDDRGTPLNKVPSILSRDVDL 328
             |..:..|       ....|:|.|       .::..|:..|:.:|..||||:|::|.:..:.:||
Frog   196 DWTYEEQF-------KQLYELDGD-------PKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDL 246

  Fly   329 YRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPCTVSVMNLVKQAYKKFLQPYGDFHRKL-GCSM 392
            |.|:..|.::||...|.::..|:.|...|.......|....::..|.|:|.||....|.| ..:.
Frog   247 YMLYVLVTEKGGLVEVINKKLWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECEKRGLSNPNE 311

  Fly   393 LMTSRNSNRSKGR------SLVRANSVASPKPMETMKTETISKLAQPNQTNVVASTSS------- 444
            |..:.:|||.:||      ||...:...:|..:.:.|.: :|.|:........:|.||
Frog   312 LQAAIDSNRREGRRQSFGGSLFTYSPSGAPSMLSSPKLQ-VSALSLGGVATNGSSLSSMQKIKKE 375

  Fly   445 ---------------SAAAASVAASSTPARAVSTASQSAAEESGNTSESSVVVEPPKKQRKGSA- 493
                           |.|..|:.|:...|:|.:........|||...|..:.:...::||...|
Frog   376 EDSPISLTVPPRIPVSLAGHSMVAAQVAAQAAALEQLREKLESGEPPEKKMALGTEEQQRLQRAI 440

  Fly   494 -----ASSQQGKVKSLVEKYEE--KSTAVQATSSGT--------VAGSGASASAAAMPTTSAAAS 543
                 |.:.|..:...:....|  :.:||..|::||        :.|...:....|.|.|||:.:
Frog   441 QHNLLAMTAQLPMNIRINSQAEGRQDSAVNLTTNGTNSISMSVELNGIVYTGVLFAQPPTSASGT 505

  Fly   544 T--ATNLSSATSGGSAT 558
            :  ::|.:.:..|||:|
Frog   506 SKGSSNRTGSIGGGSST 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392	19/108 (18%)
		ARID	299..381	CDD:279697	24/81 (30%)
		Tudor-knot	692..751	CDD:288553
arid3a	NP_001011106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..172		22/105 (21%)
		ARID_ARID3A	193..325	CDD:350642	39/145 (27%)
		Important for nuclear localization. /evidence=ECO:0000250	408..450		8/41 (20%)
		Homodimerization. /evidence=ECO:0000250	452..473		3/20 (15%)
		Important for cytoplasmic localization. /evidence=ECO:0000250	497..504		4/6 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..541		8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940