DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htk and arid-1

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	NP_001300004.1	Gene:	arid-1 / 4363100	WormBaseID:	WBGene00044689	Length:	1648	Species:	Caenorhabditis elegans

Alignment Length:	1864	Identity:	351/1864 - (18%)
Similarity:	543/1864 - (29%)	Gaps:	809/1864 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DDPPSLPVGTEVSAKYKGAFCEAKVSKVVRNIKVKVAYKQG-LGSGIVSDDAIKAPTGQLRVGAV 68
            |||..|.:|||||||:|||:||||:.||.|::||||:.|:. .|..||.|:.:  |..:..:..:
Worm     3 DDPAFLALGTEVSAKFKGAYCEAKIQKVDRSLKVKVSLKESPFGQMIVQDNDL--PNAKFEINEL 65

  Fly    69 VEVRHPDRKELVEATITKIQDCSQYTVVFDDGDITTLRRTALCLKSGRHFNESETLDQLPLTHPE 133
            .:|..  :::.:...|..|:|.|:|.|||:|||...||||.|.||.|:||.....||.:|||:||
Worm    66 TDVVF--QRKFIRCQIQSIKDQSKYHVVFNDGDEKELRRTQLVLKGGKHFAADGNLDSMPLTNPE 128

  Fly   134 HFGNPVVGG--RRGRRR--------------------------------GHLNEDSSEDDDESDA 164
            .|..||:.|  :||.::                                |...||:.:|||:::.
Worm   129 SFSTPVIRGAAKRGAQKIRNAISEASGSRGGAVLLHNDDDENDEEDQEDGENEEDADDDDDDTEE 193

  Fly   165 KE--------------------------------------------------------------- 166
            ::
Worm   194 QQQPRERRRAAAISAIGVLKKAIEDTQSEESSADSSEERERARSRRKRKDEASSAVTSDEEDQED 258

  Fly   167 ---------VVN----------------------------EKEENIGKVVCVETESKKKDKEK-- 192
                     |:|                            ::||...|:...|...:||.:||
Worm   259 LATTDSENPVINGASSAAALSKTLQRKLEKQAMKREKQRLKEEEREEKLRLKEENREKKRREKAR 323

  Fly   193 ----------------------------------------------------------------- 192

Worm   324 IMELKRLEKVYRTSNARIQENHEKSMTQIISHRSVRYFARFSDLKHRRKKKKLYLHEHRQKVNSR 388

  Fly   193 ----------------------------------------------------------------- 192

Worm   389 IRNVKLYFAWRFVAHKARLSYFARYALQWWRTSEDQAYSLIRTEKLLRSQRRRDWVGSWLEGLER 453

  Fly   193 -------------------------------------------------------WFPALVVAPT 202
                                                                   |||| |:.|.
Worm   454 EKIRFVVIHESYTQARRILKYIERGTEKRTFAERCDIEYEDIESSTVSSHFRDQEWFPA-VLFPQ 517

  Fly   203 A----------QATVR-------IRVKDEYLV-------RSFKDGRYYTVPK--------KEATE 235
            .          |..||       ::|.::.||       .||.|....|..|        |.|..
Worm   518 VFSDENGSEGRQRIVRHMGNGQLVQVWEDDLVPFDWLPEYSFADVTAMTEKKPVEMRRKFKLAWR 582

  Fly   236 FTREVA-SKQDVPAVQAALEF---------LDSSVLPAH--------WDRDSLFGLTNISSDDEG 282
            |..:.| ::.|..::::.||:         |..:.:|..        .|.|.|     :|:.:|.
Worm   583 FATDYAQNRLDARSIRSILEWKFIRPSSRRLKITPIPVQAPSPNRCGEDHDDL-----VSTPNES 642

  Fly   283 EIDSDSS-DDEPHEEKDRFVAQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTS 346
            :.|||:: .:...|.||.|||.|.::.|...:.::..|:|...:||||.|:...:|.||..:|.:
Worm   643 DYDSDATIKNVDAETKDLFVAMLVQFHDAHNSVIDTNPTIQGHEVDLYYLYELAKKTGGPKKVYA 707

  Fly   347 QNQWKLIAMRLGFTPCTVSVMNLVKQAYKKFLQPYGDFHRKLGCSMLMTSRNSNRSKGRSLVRAN 411
            .|.|...|.:|  .|........:|..:|.||:.|...:.||..
Worm   708 ANLWSDYAKKL--VPAATDAEEELKTIFKNFLESYLAINTKLSW--------------------- 749

  Fly   412 SVASPKPMETMKTETISKLAQPNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEESGNTS 476
                  |||:::..|..|:..|.|.:......:.|..:.|   .||..|..::
Worm   750 ------PMESLQPRTERKVVLPGQYSESRKKRTQAIMSQV---QTPPTAPGSS------------ 793

  Fly   477 ESSVVVEPPKKQRKGSAAS-SQQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAM--PTT 538
                     ||.|.||..: .::.||.|  |..:.|....:::|..|.|..|.|....:.  |..
Worm   794 ---------KKGRVGSGGTRGRKRKVSS--ESVQLKKRNRKSSSRATTASPGPSEDRFSFQRPQD 847

  Fly   539 SAAASTATNLSSATSGGSATIATTAMNKDAESDLPLAKIKAAAVAAASTRHSMEKETNISSGSSA 603
            |   ...|::....:             |.|..||          .|:||...|:::......|.
Worm   848 S---DDVTDVPDDMT-------------DHEDLLP----------EAATRKKYERKSQTPGRRSL 886

  Fly   604 SASSKANSAEMQRSRDASP---SVAAPPSAGASTSGAAATAQTASNKKEKHQRSKQADKEKDKDK 665
            |:          |..|.:|   ..||||..|........|....|..|
Worm   887 SS----------RRDDTTPVSSMAAAPPKKGRPRKNTTVTTPVLSVPK----------------- 924

  Fly   666 EEKQASSGKRKKEKISVEKIDTGDFVVGI--GDKLKVNYHEKKSPSSHGSTYEAKVIEISVQ--- 725
                 |.|:..:::.:..|....:.:..|  |.||:..|.::        .:.|..||.:..
Worm   925 -----SEGRGPRKEDTTTKFVRANVLSHILSGQKLRAFYGDE--------WFRANAIEDATDCTD 976

  Fly   726 ------------------RGVPMYL-------------VHYTGWNNRYDEWVPRERIA------- 752
                              |..|..:             .||||||.||||::..|::.
Worm   977 EIMDIMLAHQDFFTPDTPRLSPSAIQDLDKVLKKIRAKTHYTGWNQRYDEFMKLEKLMVTVEDQM 1041

  Fly   753 ------ENLTKGSKQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGGGSLLVQ-----GSQPPGV 806
                  .:|.:|.:.|..|::                             ||:     ..:..||
Worm  1042 IARGRFRHLPRGRELKAETLA-----------------------------LVEKHFRADDEDDGV 1077

  Fly   807 -----------------SDKQPGKDGCSKMSPSSGNSTGPGAPSLSGSLGGASSTPSLLSTVVKT 854
                             |:|:...|........:.....|...:.:...||.|.:..  ....||
Worm  1078 PKTLAFYLKIAQEALSLSEKRAVADDDESSDSDTDFEQKPDTSAAAAVNGGKSESEE--EEEEKT 1140

  Fly   855 PPTGGAKRGRGRSDSMPPRSTTPSSVVAHSGRTKSPAASQPQLQQQMKKRPTRVVPGTTTPRRVS 919
            ...||        |...........|:..|...:||    |...|           |||||...:
Worm  1141 VVMGG--------DEEAEEEVKSEDVLVESVDQESP----PTTSQ-----------GTTTPETAA 1182

  Fly   920 DASMASESDSDSDEPVRR----PKRQSAKDKP------QAGKAQPPGKGRLASSASSTAPAAHPS 974
            ...:.||||.....||..    |.....::.|      ..|.:..|...|..|..|..:|...|:
Worm  1183 TGGLESESDEPEYPPVPEELVPPPPVLLENFPSTDRFSSGGSSNYPTLSRQGSINSMASPMFSPN 1247

  Fly   975 DD----------------------------------------SEEDEEEEEPSAARAASSKQQQQ 999
            .|                                        ||..|..|.|....|||..::.:
Worm  1248 SDLSLSGPLTLPRSGPLTMANIRQSPTPDEVVGSLRKRLSQTSESSESSELPPPPSAASKSKRIR 1312

  Fly  1000 QASSLRGSRAGGNRAM-----------SSGAASAKGRDYDLSEI-------------------RS 1034
            :||......|..:..|           ||||..     :|:|..                   |.
Worm  1313 RASERSIDSASEHHRMMRSPRILTTQHSSGALI-----FDISTTQPTDTSGPIEALSVRKPGRRK 1372

  Fly  1035 ELKGFQPKLLTN-----------------AASNEERKDLA--KKEPSDEPALQDIKKEPKLESSA 1080
            .:....|.|||:                 |.....:|.|.  :|.||..      .::|:.|..|
Worm  1373 TVFAASPTLLTSGPLTLSSSAPPPPPASPAPPQHAQKTLGRPRKTPSTS------SRKPEEEDEA 1431

  Fly  1081 KS------SSTELSSETESYADEDSQSSDYRKQLKGSGAGKKEPTASPSKLHHEPVTKRELAVKE 1139
            :.      ..||.:|..:|.|.||..|.|      ||...:.|...|.|....:.:|.:.:...:
Worm  1432 EQIPTTVVGVTEEASVADSSAKEDLTSED------GSATPQDEKDDSESTTTTDTITPKSIRGGK 1490

  Fly  1140 E-----------PLK-IEPKTEPKEEETKSKPFLSGADIKPTALIAPARFGNTSAAQAASSSGSS 1192
            .           |:| .:|..:||:...:     .|||.|......|.....::..:|.|.....
Worm  1491 RRRGGGRFGGSYPVKPAKPGRKPKDPHAE-----EGADEKDPEDQTPTTMTTSTPTRADSFQTQK 1550

  Fly  1193 STTAK----------------YTSVIVEKPLTIGGKKSV----EQHVPKKAELLKKQSGGAGGTA 1237
            :..||                :..:|.|.|     |:.:    |:...:..|:..:       ..
Worm  1551 NRMAKLMEGKPHDYSFLDLPDFDKIIEEAP-----KEDINILMEERTYELREIFAQ-------CK 1603

  Fly  1238 ASSSAASQESKKFAEPVASLKVEMPA-ACSPSSSSSSSSSFCST 1280
            |..||..:..::..|  |..|.|..| ..|.::::.:|||.|||
Worm  1604 ADLSALEKRYRQQNE--AKRKAEFAAKTASSAAAAQASSSTCST 1645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392	33/319 (10%)
		ARID	299..381	CDD:279697	25/81 (31%)
		Tudor-knot	692..751	CDD:288553	21/94 (22%)
arid-1	NP_001300004.1	ARID	658..740	CDD:198082	27/83 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159845
Domainoid	1	1.000	51	1.000	Domainoid score	I7747
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1624495at2759
OrthoFinder	1	1.000	-	-		FOG0003167
OrthoInspector	1	1.000	-	-		oto17457
orthoMCL	1	0.900	-	-		OOG6_106607
Panther	1	1.100	-	-	LDO	PTHR13964
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.870