DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htk and osa

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	NP_001163639.1	Gene:	osa / 42130	FlyBaseID:	FBgn0261885	Length:	2716	Species:	Drosophila melanogaster

Alignment Length:	2387	Identity:	447/2387 - (18%)
Similarity:	662/2387 - (27%)	Gaps:	849/2387 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   424 TETISKLAQ------PNQTNVVASTSSSAAAASVAASST-------------------------- 456
            |.|::.|.|      |.|.....:.....||||.||::.
  Fly   212 TPTLNSLLQSSNPPPPPQHRYANTYDPQQAAASAAAAAAAQQQQAGGPPPPGHGPPPPQHQPSPY 276

  Fly   457 ---------PARAVS----TASQSAAEESGNTSESSVVVEPPKKQRKGSAASSQQGKVKSLVEKY 508
                     |.|..|    .:.|.......|||.......|...|..||..||.|.:.:...::.
  Fly   277 GGQQGGWAPPPRPYSPQLGPSQQYRTPPPTNTSRGQSPYPPAHGQNSGSYPSSPQQQQQQQQQQQ 341

  Fly   509 EE--------------KSTAVQATSSGTVAGSGASASAAAMPTTSAAASTATNLSSATS------ 553
            ::              ..|..|.....|...|..|......||.....:..:|..:|.|
  Fly   342 QQAGQQPGGPVPGGPPPGTGQQPPQQNTPPTSQYSPYPQRYPTPPGLPAGGSNHRTAYSTHQYPE 406

  Fly   554 ------GGSATIATTAMNKDAESDLPLAKIKAAAVAAASTRH--SMEKE----TNISSGSSASAS 606
                  |||        :....|..||        ..||..|  .::::    .::|:|....:|
  Fly   407 PNRPWPGGS--------SPSPGSGHPL--------PPASPHHVPPLQQQPPPPPHVSAGGPPPSS 455

  Fly   607 SKANSAEMQRSRDASPSVAAP-------------PSAGASTSGAAATAQTASNKKEKHQRSKQAD 658
            |..::.    |....||.|:|             .|:|.:.||..:......|.::..
  Fly   456 SPGHAP----SPSPQPSQASPSPHQELIGQNSNDSSSGGAHSGMGSGPPGTPNPQQVM------- 509

  Fly   659 KEKDKDKEEKQASSGKRKKEKISVEKIDTGDFVVGIGDKLKVNYHEKKSPSSHGSTYEAKVIEIS 723
                :.......|||.|.......:.                  |....|:|:.|:....:.:..
  Fly   510 ----RPTPSPTGSSGSRSMSPAVAQN------------------HPISRPASNQSSSGGPMQQPP 552

  Fly   724 VQRGVPMYLVHYTGWNNRYDEWVPRERIAENLTKGSKQKTRTISTSSANSGSGGG---------- 778
            |..|.|..:..:.|                 :..|..|:.::....::||.|...
  Fly   553 VGAGGPPPMPPHPG-----------------MPGGPPQQQQSQQQQASNSASSASNSPQQTPPPA 600

  Fly   779 ------------------GGGGGG--------GGGGGGGGGGSLLVQGSQPPGVSDKQPGKDGCS 817
                              |..|||        ||...||.|.|...||..|.......||.....
  Fly   601 PPPNQGMNNMATPPPPPQGAAGGGYPMPPHMHGGYKMGGPGQSPGAQGYPPQQPQQYPPGNYPPR 665

  Fly   818 KMSPSSGNSTGPGAPSLS-GSLGGASSTPSLLSTVVKTPPTGGAKRGRGRSDSMP---------- 871
            ...|....:|||..|..| ...|||:|.||            ||:.|......||
  Fly   666 PQYPPGAYATGPPPPPTSQAGAGGANSMPS------------GAQAGGYPGRGMPNHTGQYPPYQ 718

  Fly   872 -----PRSTTPSSVVAHSGRTKSPAASQPQLQQQMKKRPTRVVPGTTTPRRVSDASMASESDSDS 931
                 |:.|.|..         :|..:......|.|..|...|.|...|          ...|.|
  Fly   719 WVPPSPQQTVPGG---------APGGAMVGNHVQGKGTPPPPVVGGPPP----------PQGSGS 764

  Fly   932 DEPVRRPKRQSAKDKPQAGKAQPP------GKGRLASSASSTAPAAH----PSDDSEEDEEEEEP 986
            ..|:...|:.........|...||      |.|.............|    |...:........|
  Fly   765 PRPLNYLKQHLQHKGGYGGSPTPPQGPQGYGNGPTGMHPGMPMGPPHHMGPPHGPTNMGPPTSTP 829

  Fly   987 SAARAASSKQQQQQASSLRGSRAGG-------NRAMSSGAASAKGRDYDLSEIRSELKG------ 1038
            ..::.....|.|.|.:| .|..:||       |...|||...|.|.....|.:.:...|
  Fly   830 PQSQMLQGGQPQGQGAS-GGPESGGPEHISQDNGISSSGPTGAAGMHAVTSVVTTGPDGTSMDEV 893

  Fly  1039 FQPKLLTN--AASNEERKDLAKKEPSDEPALQDIKKEPKLESSAKSSSTELSSETESYADEDSQS 1101
            .|...|:|  |||.|:.:....|...::|                        .::|:....|.|
  Fly   894 SQQSTLSNASAASGEDPQCTTPKSRKNDP------------------------YSQSHLAPPSTS 934

  Fly  1102 SDYRKQLKGSGAGKK----------EPTASPSKLHHEPVTKRELAVKEEPLKIEPKTEPKEEETK 1156
            ........|.|.|::          .|..||...:|.|       |.:||.: ...|..|:.::.
  Fly   935 PHPVVMHPGGGPGEEYDMSSPPNWPRPAGSPQVFNHVP-------VPQEPFR-STITTTKKSDSL 991

  Fly  1157 SKPFLSGADIKPTALIAPARFGNTSAAQAASSSGSSSTTAKYTSVIVEKPLTI----------GG 1211
            .|.:....:        |.|.|.....:|......:..||..|  |.::||.:          ||
  Fly   992 CKLYEMDDN--------PDRRGWLDKLRAFMEERRTPITACPT--ISKQPLDLYRLYIYVKERGG 1046

  Fly  1212 KKSVEQHVPKKAELLK----KQSGGAGGTAASSSAASQESKKFAE-----------------PV- 1254
                      ..|:.|    |...|..|..||||||....|.:.:                 |:
  Fly  1047 ----------FVEVTKSKTWKDIAGLLGIGASSSAAYTLRKHYTKNLLTFECHFDRGDIDPLPII 1101

  Fly  1255 -----ASLKVEMPAACSPS--------------SSSSSSSSF-CSTGSAVSSS-SATRSLPDMSK 1298
                 .|.|....||..||              .||:|..|| ...|||.::: ......|..|.
  Fly  1102 QQVEAGSKKKTAKAASVPSPGGGHLDAGTTNSTGSSNSQDSFPAPPGSAPNAAIDGYPGYPGGSP 1166

  Fly  1299 LEISSGTVPG-ATPGAAALQPS-NVAQVSSSGAAKESKYSSSGGAAAGSGISMRKLLSSDVYEFK 1361
            ..::||..|. ||.|.....|| |..|....|||        ...|||..||:
  Fly  1167 YPVASGPQPDYATAGQMQRPPSQNNPQTPHPGAA--------AAVAAGDNISV------------ 1211

  Fly  1362 DTEPFEFEKRISPMASVGGTVAAAATAAGAMAAAGAASVITTMVPTPGASGSGVAASASTSAPVV 1426
             :.|||     .|:|:.||..:......|.....||||        .||...|.........|..
  Fly  1212 -SNPFE-----DPIAAGGGPGSGTGPGPGQGPGPGAAS--------GGAGAVGAVGGGPQPHPPP 1262

  Fly  1427 VGS--AARKQALKASAIQHILEHQSPAAGRERGGYGGMTSSISLLTAPKLKKRGSPLKEAALCME 1489
            ..|  .|.:||......|| .:||.|       |..|        ..|..:::|
  Fly  1263 PHSPHTAAQQAAGQHQQQH-PQHQHP-------GLPG--------PPPPQQQQG----------- 1300

  Fly  1490 KAKTYKLDKDQVQQP-------------------VEQKTQQLIQPTLG-PVESYGAGSPEAMSNL 1534
                     .|.|||                   |....||.::|..| |....|:|.|..:|..
  Fly  1301 ---------QQGQQPPPSVGGGPPPAPQQHGPGQVPPSPQQHVRPAAGAPYPPGGSGYPTPVSRT 1356

  Fly  1535 ---STPTTSSGHAQLSASSTYSQLTPHHATPFDALRKSPSFNLNITALNEELAQTVQETTRALTD 1596
               ..|:....:.|..:|..|                                           :
  Fly  1357 PGSPYPSQPGAYGQYGSSDQY-------------------------------------------N 1378

  Fly  1597 ALQPPSTPVPPTVSASGSTPTAVTPVITAM-PTAGTAGLSCPSTPPTGAN---PVLASPKLSTPP 1657
            |..||..|.       |..|....|....| |..|..|    ..||||||   |..:.|....||
  Fly  1379 ATGPPGQPF-------GQGPGQYPPQNRNMYPPYGPEG----EAPPTGANQYGPYGSRPYSQPPP 1432

  Fly  1658 QAINASKQPPASHIVGSPFIETRNVFELSTSNEGSGYSSGESKDNKFEKLENVKILLAGAVGPFD 1722
                ...|||...:.|.|
  Fly  1433 ----GGPQPPTQTVAGGP----------------------------------------------- 1446

  Fly  1723 LDAGSYEQKTSSIADKVLKAISQKKEEVENNKGKPPVEPAAAAKTPGREDVVPSPTAKLDLCSSA 1787
             .||                            |.|...|::|..| ||
  Fly  1447 -PAG----------------------------GAPGAPPSSAYPT-GR----------------- 1464

  Fly  1788 IKLDTLKLLSEPLKIQTGPLLGELYRPGPATSSPETK---SILESSLPAKNSELSETIQKLECAI 1849
                              |...:.|:| |...||:.:   ..::.|.|.........|.....:.
  Fly  1465 ------------------PSQQDYYQP-PPDQSPQPRRHPDFIKDSQPYPGYNARPQIYGAWQSG 1510

  Fly  1850 QQRKTPVGGALSLASSTAGTPPTAHTPNSTATAG------AGFSDESMDSTDSEQRLVIEDVIAE 1908
            .|:..|...:.....:..|.||....|...|..|      ||.:.                  .:
  Fly  1511 TQQYRPQYPSSPAPQNWGGAPPRGAAPPPGAPHGPPIQQPAGVAQ------------------WD 1557

  Fly  1909 EHTTTTTTGEQKSPGSQQEEGQTNTATMATAVTAETEGTSSSTPTPPVPAPVKLELGAKAMPGIQ 1973
            :|......|....|..||:..|.........|.    |.....|....|...::..|..|..||.
  Fly  1558 QHRYPPQQGPPPPPQQQQQPQQQQQQPPYQQVA----GPPGQQPPQAPPQWAQMNPGQTAQSGIA 1618

  Fly  1974 AP-IPLKPAEGSSFAGKLTGVVQPPPLAKLQQQEELGQAQGQSKSISSFGIPIVLPEIPASVVVA 2037
            .| .||:|..|.....::.|:    |..:.|.|::.|..|...:..|..|:|
  Fly  1619 PPGSPLRPPSGPGQQNRMPGM----PAQQQQSQQQGGVPQPPPQQASHGGVP------------- 1666

  Fly  2038 TPALMVASAATVMRHSPGSTPNSQAPVLISPKTFLTAPKVGEVGGLLLKAYT-------GVSGAV 2095
                           |||                  .|:||. ||::...|.       ||...|
  Fly  1667 ---------------SPG------------------LPQVGP-GGMVKPPYAMPPPPSQGVGQQV 1697

  Fly  2096 GAAPAGSVIASAGGGGTPTVISNFPQQQQQASVLQASSEMPANYVLDAEMAEPSNSSAPVVARPF 2160
            |..|.|.:::..........:...|.|||..|...........:....:|  |.|.:||....|.
  Fly  1698 GQGPPGGMMSQKPPPMPGQAMQQQPLQQQPPSHQHPHPHQHPQHQHPHQM--PPNQTAPGGYGPP 1760

  Fly  2161 VMHAVGKELFNVVAPAASSPLISDPHN--ESI--------NLLCEETIPGSP-----APNYGGTD 2210
            .|...|.:|       ....||. ||:  ||.        .|:..:..|..|     |...|...
  Fly  1761 GMPGGGAQL-------VKKELIF-PHDSVESTTPVLYRRKRLMKADVCPVDPWRIFMAMRSGLLT 1817

  Fly  2211 QLPTAV---------NSALAIVGITPLPPDTPPPVPVAAIQQQQQHQLQSGQQQQAAKTGEVNPS 2266
            :...|:         :|.:...||:.|     |.:....::..|::..:...:::
  Fly  1818 ECTWALDVLNVLLFDDSTVQFFGISNL-----PGLLTLLLEHFQKNLAEMFDERE---------- 1867

  Fly  2267 GPNSSPDSASQDESGEEAKKNAGLEHEDSTGLGALNKRKRNRKPLPMSAQTAAAVAAQLQSLGKR 2331
              |....:...:::.::|         ||..:.....|...|:|     :...::::.     .|
  Fly  1868 --NEEQSALLAEDADDDA---------DSGTVMCEKLRTSGRQP-----RCVRSISSY-----NR 1911

  Fly  2332 RRQVSGMRNQKTTTTAAGSDTDDNSDNIAPNAGQQQQQPRQSARQHMM----------------- 2379
            ||....|..........|||::|..:.|  :.||.:.||....|..::
  Fly  1912 RRHYENMDRSGKDGAGNGSDSEDADEGI--DLGQVRVQPNPEERSLLLSFTPNYTMVTRKGVPVR 1974

  Fly  2380 ---PQSNAQQQQQQQLLQQQQTQLPQGIQSTNSSGVRPCPYNFLVELDPALSSDECITILRKQIQ 2441
               .:::....::|:.......:|.:.::...|..   ..|.| .|.||.   |..|.:.:.:|.
  Fly  1975 IQPAENDIFVDERQKAWDIDTNRLYEQLEPVGSDA---WTYGF-TEPDPL---DGIIDVFKSEIV 2032

  Fly  2442 DL---RKAYNTIKG----ELAVIDRRRKKLRRREREKKQQQLQSQQQ 2481
            ::   |...:..||    ||| ...|:.:::..|...::|....:::
  Fly  2033 NIPFARYIRSDKKGRKRTELA-SSSRKPEIKTEENSTEEQTFNKKRR 2078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392
		ARID	299..381	CDD:279697
		Tudor-knot	692..751	CDD:288553	8/58 (14%)
osa	NP_001163639.1	BRIGHT	1001..1092	CDD:128777	24/102 (24%)
osa	NP_001163639.1	DUF3518	2191..2451	CDD:288854
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.940