DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htk and Usf3

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	XP_006248418.1	Gene:	Usf3 / 303946	RGDID:	1560175	Length:	2222	Species:	Rattus norvegicus

Alignment Length:	1748	Identity:	362/1748 - (20%)
Similarity:	610/1748 - (34%)	Gaps:	413/1748 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   889 SPAASQPQ---LQQQMKKRPTRVVPGTTTPRRVSDASMASESDSDSDEPVRRPKRQSAKDKPQAG 950
            |||..|.:   |.|..|.        .|..:|.:|..:.:...|:..|.:::.::|..:.:.:.|
  Rat    48 SPALKQSKNMILDQAFKY--------ITELKRQNDELLLNGGSSEQAEEIKKLRKQLEEIQKENG 104

  Fly   951 ------KAQP---------PGKGRLASSASSTAPAAHPSDDSEED----EEEEEPSAARAASSKQ 996
                  ||..         ..||.|.:|..|   ...|||..:::    ....:|......::.|
  Rat   105 RYIELLKANDICLYDDPTIHWKGNLKTSKVS---VVIPSDQVQKNIIVYSNGSQPGGNSQGTAVQ 166

  Fly   997 ----------QQQQAS--------------SLRGSRAGGNRAMSSGAASAKGRDYDLSEIRSELK 1037
                      |:|.|:              |:.|.....|:.......||...:..:
  Rat   167 GITFNVGHGLQKQTANVVPVQRTCKLVTPVSISGIYPSENKPWHQTTVSALAANQSV-------- 223

  Fly  1038 GFQPKLLTNAASNEERKDLAKKEPSDEPAL---------QDIKKEPKLESSAKSSSTELSSETES 1093
               |..|..|.|.:...:|:..| |...||         ..:..:|....|..:...:.::...|
  Rat   224 ---PLCLPTAISAQNILELSTSE-SQSSALGATGGSVVTTSVGPDPHQHRSLNTCLNDQNASENS 284

  Fly  1094 YADEDSQSSDYRKQLKG-SGAGKKEPTASPSKLHHEPVTKRELAVKEEPLKIEPKTEPKEEETKS 1157
            ...|..:||  :|.:.. ||.......|:|. :|||  ||..||.:.
  Rat   285 NVQESPKSS--KKTVSSVSGTSSSNSAAAPG-VHHE--TKSSLATQG------------------ 326

  Fly  1158 KPFLSGADIKPT--ALIAPARFGNTSAAQAASSSGSSSTTAKYTSVIVEKPLTIGGKKSVEQHVP 1220
                |.||.:.|  ::..|.      ::|...|:||||            |:::  .|:|:
  Rat   327 ----SSADSQNTLVSITTPV------SSQPPRSTGSSS------------PVSV--SKTVD---- 363

  Fly  1221 KKAELLKKQSGGAGGTAASSSAASQESKKFAEPVASLKVE-----MPAACSPSSSSSSSSSFCST 1280
                        ...|||:...|.....|.|.||:||...     ...:||..|||.|:|...:.
  Rat   364 ------------PTNTAAAVVPAHTAVSKSALPVSSLSATPLEGGWTLSCSLPSSSVSASELKNI 416

  Fly  1281 GSAVSSSSATRSLPDMSKLEISSGTV-PGATPGAAALQPSNVAQVSSSGAAKESKYSSSGGAAAG 1344
            .|....|||..:....:.|.::..|: |.:.|.::|..|: :.:..:|......|:.::|.....
  Rat   417 NSLTRISSAGNTQTTWTTLHLAGNTIQPLSQPPSSASTPA-LNECGTSPTPSNHKHMATGITFNN 480

  Fly  1345 S-------------------GISMRKLLSSDVYEFKDTEPFEFEKRISPMASVGGTV-AAAATAA 1389
            |                   .:.|:.|::..  :.|...|    |.|.|:.|....: .|....:
  Rat   481 SPPTDGQPVEQIVVTLPSCPPLPMQPLIAQP--QVKSQPP----KNILPLNSAMQVIQMAQPVGS 539

  Fly  1390 GAMAAAGAASVITTMVPTPGASGSGVAASASTSA---PVVVGSAARKQALKASAIQHILEHQSPA 1451
            |..||....:||....|:.....:.:.|..|..|   .:|:..||.:..|...:..|....:.|.
  Rat   540 GVTAAPANQNVIILQPPSTTPCPAMMRAEVSNQAVGQQIVIIQAANQNPLPLLSAPHPGPVRLPV 604

  Fly  1452 AGRERGGYGGMTSSISLLTAPK---------LKKRGSPLKEAALCMEKAKTYKLDKDQVQQP-VE 1506
            .|  .....|..:|:..:.||:         :..|.|.|..:    ..|:|:.:.....||| ..
  Rat   605 NG--ASAIIGSHNSVQNVPAPQTFGGKHLVHILPRPSSLSTS----NSAQTFSVTMSNQQQPQTI 663

  Fly  1507 QKTQQLIQPTLGPVESYGAGSPEAMSNLSTPTTSSGHAQLSASSTYSQLTPHHATPFDALRKSPS 1571
            ....||.  .|.||.|....:.::...:..||||.......|.:|:..|.        :|.:|.|
  Rat   664 SLNGQLF--ALQPVMSSSGTTNQSPMQIIQPTTSEDPNTNVALNTFGALA--------SLNQSIS 718

  Fly  1572 FNLNITALNEELAQTVQETTRALTDALQPPS----TPVPPTVSASGSTPTAVTPVITAMPTAGTA 1632
            .....:.:...::|:....|.| .....|.:    |.|.||::|..|...:.|..:....:..|
  Rat   719 QMAGQSCVQLSISQSANPQTSA-NSQTSPTNCVSLTTVAPTMTAENSATQSTTYSLATASSTNT- 781

  Fly  1633 GLSC-PSTPPTGANPVLASPKLSTPPQAINASKQPPASHIVGSPFIETRNVFE-----LSTSNEG 1691
             ::| |||        :.|.:||..|.|    |:..|::....|....|:|.:     :.:|.|.
  Rat   782 -VTCLPST--------MKSKRLSKKPSA----KKHLAANKPACPLNSVRDVGKMDGPGMDSSAEP 833

  Fly  1692 S-----------GYSS---GESKDNKFEKLENVKILLAGAVGP-FDLDAGSYEQKTSS-----IA 1736
            |           |.||   .::|........::.||.:.:|.| .|..:.|.|..:||     ..
  Rat   834 SCSDGLLNGLPVGLSSVTVSQAKSVSISASHSLDILNSESVIPESDSKSKSAEDCSSSSRESEAN 898

  Fly  1737 DKVLKAISQKKEEV----ENNKGKPPVE---PAAAAKTPGREDVVPSPTAKLDLCSSAIKLDTLK 1794
            :::..|.::.|:..    |:::|.||..   |.|.........:.||||....|.|....:.:..
  Rat   899 EQLALATAKSKDSTPILQESSQGTPPCSVALPNATKSCASANVLTPSPTESESLVSQVSGMPSTT 963

  Fly  1795 LLSEPLKIQTGPLLGELYRPGPATSSPETKSILESSLPAKNSELSETIQKL--ECAIQQRKTPV- 1856
            ..|..:.|....::.|     |.....|:...::::.|.|...|:..:..|  |..:|:...||
  Rat   964 STSNTVCISEVEIVAE-----PCPVQQESLDTMQAAGPLKGQGLTMLLSDLAKEKDLQRTSLPVQ 1023

  Fly  1857 --GGALSLASSTAGTPPTAHTPNSTATAGAGFSDESMDSTDSEQRLVIEDVIAEEHTTTTTTGEQ 1919
              ....|..||..|.|.....|.....    .:.:..|.......|..::||   |.:..|:.:.
  Rat  1024 MDHPDFSPESSKIGDPNVDLHPKQELL----LTSDDRDLPQPHSCLPDQEVI---HGSLLTSRQA 1081

  Fly  1920 KSPGSQQEEGQTNTATMATAV--TAETEGTSSSTPT--------------PPVPAPVKLELGAKA 1968
            .||.| ...|.:.:.::|:.:  ||..:.|||:|.|              ....|.:..|...|.
  Rat  1082 DSPMS-TSSGSSRSFSVASMLPETAREDVTSSTTNTCDSCTFAEQTDIVALAARAILDQESIEKG 1145

  Fly  1969 MPGIQA---PIPLKPAEGSSFAGKLTGVVQPPPLAKLQQQEELGQAQGQSKSISS-------FGI 2023
            ..|.||   .:..||:|.|     |.|  ..|...::.::...|||.......:|       ...
  Rat  1146 RLGTQADLKDVTPKPSETS-----LEG--DQPFKPQIHKETCTGQADPTPNEFNSQDSVEVTVDR 1203

  Fly  2024 PIVLPEIPASVVVATPALMVASAATVMRHSPGSTPNSQAPVLISPKTFLTAPKVGEVGGLLLKAY 2088
            |:..|.....:..:.|.|.|::              ||.|.| :.:..::.|.|...|.......
  Rat  1204 PLEKPSCSLGIKASNPPLQVSA--------------SQPPSL-THQNSISRPLVSCAGLSQSSDQ 1253

  Fly  2089 TGVSGAVGAAPAGSVIASAGGGGTPTV---ISNFPQQQQQASVLQASSEMPANYVLDAEMAEP-- 2148
            |.:...|     ...:||:..|..|.|   ::.:.|:|..:.         ||.:.:.::.||
  Rat  1254 TAIPVTV-----NMTVASSAYGSQPPVPPLMTEYSQEQLNSM---------ANSIPNPQVQEPLS 1304

  Fly  2149 -------SNSSAPVVARPFVMHAVGKELFNVVAP--AASSPLIS-DPHN--ESINLLCEETIPGS 2201
                   .:|:...|....::.:..::.....||  ..|.||:| .|.|  :...::..:..|.|
  Rat  1305 KPSHESRKDSAKRTVQDDLLLSSAKRQKHCQPAPLRLESVPLMSRTPDNIPDQTQMMASQITPNS 1369

  Fly  2202 ---------PAPNYGGTDQLPTAVNSALAIVGITPLPPDTPPPVPVAAIQQQQQHQLQSGQQQQA 2257
                     ||...|.|...|...|.|..::....:..:..|.|      .:|..|.|:||..||
  Rat  1370 SNSVVPVSNPAHGDGLTRLFPAGNNFAAPVLRQADVQCNPQPSV------AEQPQQTQAGQHLQA 1428

  Fly  2258 AKTGEVNPSGPNS-------SPDSASQDESGEEAKKN--AGLEHEDSTGLGALNKRKRNRKPLPM 2313
            .:. .|.|.|.:.       ......|.::|:..:::  ..|:|.......|::.     :|..:
  Rat  1429 LQQ-HVPPQGVSHLHTNHLYLKQQQQQQQAGQLRERHHLYQLQHHVPHADNAVHS-----QPHIV 1487

  Fly  2314 SAQTAAAVAAQLQSLGKRRRQVSGMRNQKTTTTAAGSDTDDN---SDNIAPNAGQQQQQPRQ--- 2372
            ..|.......|:|   |:|..|.|....:.:.......||.:   |....|:..|.|||.:|
  Rat  1488 HQQRTLQQEVQMQ---KKRNLVQGTPTSQLSLQPKHHGTDQSRPKSSQPHPHHQQMQQQLQQHFA 1549

  Fly  2373 ------------SARQHMMPQSNAQQQQQQQLLQQQQ----TQLPQGIQSTNSSGVRP 2414
                        |:|.|   .|:.|....|.:|.|||    .|....:.|.:.||..|
  Rat  1550 SSQPEKSCENPSSSRGH---HSHPQNHLNQDVLHQQQDVGSRQQGSAVSSDHVSGHNP 1604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392
		ARID	299..381	CDD:279697
		Tudor-knot	692..751	CDD:288553
Usf3	XP_006248418.1	bHLHzip_USF3	15..79	CDD:381480	10/38 (26%)
Usf3	XP_006248418.1	PHA03247	<311..644	CDD:223021	85/402 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000