DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htk and Arid4a

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	XP_036013289.1	Gene:	Arid4a / 238247	MGIID:	2444354	Length:	1283	Species:	Mus musculus

Alignment Length:	1681	Identity:	413/1681 - (24%)
Similarity:	608/1681 - (36%)	Gaps:	527/1681 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQQMDDPPSLPVGTEVSAKYKGAFCEAKVSKVVRNIKVKVAYKQGLGSGIVSDDAIKAPTGQLRV 65
            |:..|:|..|.|||:|||||:|||||||:..|.|.:||||..||...:.:|.||.:|.|   |||
Mouse     1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGP---LRV 62

  Fly    66 GAVVEVRHPDRKELVEATITKIQDCSQYTVVFDDGDITTLRRTALCLKSGRHFNESETLDQLPLT 130
            ||:||.|..| ..:.||.|:|:.|.|.|||||||||..|||||:||||..|||.|||||||||||
Mouse    63 GAIVETRTSD-GSIQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETLDQLPLT 126

  Fly   131 HPEHFGNPVVGGR--RGRR------RGHLNEDSSEDDDESDAKEVVNEKEENIGKVVCVETESKK 187
            :|||||.||:..:  ||||      .....|:|||::||.  |..:|  :|.:||||.|.:.:
Mouse   127 NPEHFGTPVIAKKTNRGRRSSLPITEDEKEEESSEEEDED--KRRLN--DELLGKVVSVASTA-- 185

  Fly   188 KDKEKWFPALVVAPTAQATVRIRVKDEYLVRSFKDGRYYTVPKKEATEFTREVASKQDV---PAV 249
             :...|:|||||:|:....|.:: ||:.|||||.|.::|::.:|:..|.......:.::   |.:
Mouse   186 -ESTGWYPALVVSPSCNDDVTVK-KDQCLVRSFIDSKFYSIARKDIKELDILTLPESELCARPGL 248

  Fly   250 QAALEFLDSSVLPAHWDRDSLFGLTNISSDDEGEIDSDSSDDEPH-----------------EEK 297
            :.|..||...::|.:|..|....|.:.||||| |..::..::|..                 ||:
Mouse   249 RRASVFLKGRIVPDNWKMDISEILESSSSDDE-ECPAEEHEEEKEKEAKKEEEELPEEELDPEER 312

  Fly   298 DRFVAQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPC 362
            |.|:.||||:|:|||||:||.|.:..:|::|::|||.|..:||...:.|...||.|.|.||....
Mouse   313 DNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCGNIDSGAVWKQIYMDLGIPIL 377

  Fly   363 TVSVMNLVKQAYKKFLQPYGDFHRKLGCSMLMTSRNSNRSKGRSLVRANSVASPKPMETMKTETI 427
            ..:....||.||:|:|..:.::.|......                |......||..|..|
Mouse   378 NSAASYNVKTAYRKYLYGFEEYCRSANIQF----------------RTIHHHEPKVKEEKK---- 422

  Fly   428 SKLAQPNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEESGNTSESSVVVEPPKKQRK-G 491
                         ....|...|...|...|...|.:..:...:.:..:......::.|:.:|| .
Mouse   423 -------------DFEDSMDEALKEAPEMPLLDVKSEPEENTDSNSESDREDTELKSPRGRRKIV 474

  Fly   492 SAASSQQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTATNLSSATSGGS 556
            ..|:..:.:::.  ||.|:|
Mouse   475 RDANCIKKEIEE--EKIEDK--------------------------------------------- 492

  Fly   557 ATIATTAMNKDAESDLPLAKIKAAAVAAASTRHSMEKETNISSGSSASASSKANSAEMQRSRDAS 621
             .:.....||||..|      ......||...|                       |:...|.::
Mouse   493 -FLRDDLENKDAGDD------DDDGDPAAKREH-----------------------ELLFGRKST 527

  Fly   622 PSVAAPPSAGASTSGAAATAQTASNKKEKHQRSKQADKEKDKDKEEKQASSGKRKKEKISVEKID 686
            |                      .||::|.:  |..|.|:|.|:||:::...:..:.:...|..|
Mouse   528 P----------------------KNKEKKIK--KPEDSERDSDEEEEKSQEREETESRCDSEGED 568

  Fly   687 TGDFVVG--IGDKLKVNYHEKKSPSSHGSTYEAKVIEISVQRGVPMYLVHYTGWNNRYDEWVPRE 749
            ..|....  .|.|:||.|...|:.    ..|||.:....:..|..:|||||.|||.||||||..:
Mouse   569 EEDDTEPCLTGTKVKVKYGRGKTQ----KIYEASIKSTEMDDGEILYLVHYYGWNVRYDEWVKAD 629

  Fly   750 RIAENLTKGSKQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGGGSLLVQGSQPPGVSDKQPGKD 814
            ||...|.||..:|                                              ||..|.
Mouse   630 RIIWPLDKGGPKK----------------------------------------------KQKKKV 648

  Fly   815 GCSKMSPSSGNSTGPGAPSLSGSLGGASSTPSLLSTVVKTPPTGGAKRGRGRSDSMPPRSTTPSS 879
            .|.                           |.||
Mouse   649 KCQ---------------------------PCLL------------------------------- 655

  Fly   880 VVAHS--GRTKSPAASQPQLQQQMKKRPTRVVPGTTTPRRVSDASMASESDSDSDEPVRRPKRQS 942
              ||.  |....|                  ||           ::.::.||:.||     ||..
Mouse   656 --AHCTLGHAFCP------------------VP-----------AVENKEDSEKDE-----KRDE 684

  Fly   943 AKDKPQAGKAQPPGKG--------RLASSASSTAPAAHPSDDSEEDEEEEEPSAARAASSKQQQQ 999
            .:.|.:.|:  ||.|.        .|:.:::|...:...|.|||.|::.|:.|
Mouse   685 ERQKSKRGR--PPLKSTFSPNMPYSLSKTSNSEGKSDSCSSDSEADDQLEKSS------------ 735

  Fly  1000 QASSLRGSRAGGNRAMSSGAASAKGRDYDLS-EIRSELKGFQPKLLTNAASNEERKDLAKKEPSD 1063
                      ||.               ||| :::.||:           .||...|  .|...:
Mouse   736 ----------GGE---------------DLSPDVKEELE-----------KNENAHD--DKLDEE 762

  Fly  1064 EPALQDIKKE-PKLESSAKSSSTELSSETES----YADEDSQSSDYRKQL----KGSGAGKKEPT 1119
            .|.:..|.|| .:.::....:.|..:.:::.    :.|:..|..:::||:    ||.|...|...
Mouse   763 NPKIVHISKENDRTQAQPSDTLTVEAGDSDQIVHIFGDKVDQVEEFKKQVEKSPKGKGRRSKTKD 827

  Fly  1120 ASPSKLHHEPVTKRELAVKE-------EPLKIEPKT--------EPKEEETKSKPFLSGADIKPT 1169
            .|...:...|..:.|...:.       |...:|.|.        :|.|:|.|.|..:.|......
Mouse   828 LSLELIKISPFGQEEAGSEAHGDVHSLEFSSLECKNFSSTEDDIDPYEKEKKLKRKILGQQSPEK 892

  Fly  1170 ALIAPARFGN-----TSAAQAASSSGSSSTTAKYTSVIVEKPLTIGGKKS--VEQHVPKKAELLK 1227
            .|    |..|     |..:|..|..|:.:.                |.|.  ||||...:.|
Mouse   893 KL----RLDNGMEMTTGVSQERSDDGAGAE----------------GMKGAHVEQHFETEGE--- 934

  Fly  1228 KQSGGAGGTAASSSAASQESKKFAEPVASLKVEMPA----ACSPSSSSSSSSSFCSTGSAVSSSS 1288
                |.....|......||       :.|.|.:.||    ..:|......:.......:.|....
Mouse   935 ----GMPSLTAEPDQGLQE-------LTSEKSDSPAEEEPVHTPLKEEEDAMPLIGPETLVCHEV 988

  Fly  1289 ATRSLPDMSKLEISSGTVPGATPGAAALQPSNVAQVSSSGAAKESKYSSSGGAAAGSGISMRKLL 1353
            ....|.:..|..|....|.|:...:.|..|..:..|:....:..|..:.|...:       |.:.
Mouse   989 DLDDLDEKDKTSIEDVVVEGSESNSLASVPPALPPVAQHNFSVASPLTLSQDES-------RSIK 1046

  Fly  1354 S-SDVYEFKDTEPFEFEKRISPMASVGGTVAAAATAAGAMAAAGAASVITTMVPT-------PGA 1410
            | ||:....|:...|.::.:....|..|..|:        .|:||.|:|.....:       |..
Mouse  1047 SESDITIEVDSIAEESQEGLCERESANGFEAS--------VASGACSIIAHERESREKGQKRPSD 1103

  Fly  1411 SGSGVAASASTSAPVVVGSAARKQALKASAIQHILEHQSPAAGRERGGYGGMTSS-----ISLLT 1470
            ..||:.|......|....:||:.:  |..|.|.......||          |.||     :..||
Mouse  1104 GNSGLIAKKQKRTPKRTSAAAKTE--KNGAGQSSDSEDLPA----------MDSSSNCTPVKRLT 1156

  Fly  1471 APKLKK------RGSP-LKEAALCMEKAK-----------TYK-------LDKDQVQQPVE--QK 1508
            .||.:|      |.|| :|:|    ||.|           |||       ||.....:.:.  |:
Mouse  1157 LPKSQKLPRSPARTSPHIKDA----EKEKHREKHPNSSPRTYKWSFQLNELDNMNSTERISFLQE 1217

  Fly  1509 TQQLIQPTLGPVESYGAGSPEAMSNLSTPTTSSGHAQLSASSTYSQ--LTPHHATP 1562
            ..|.|:.....::|..|........|........||..|.||..|.  ::|..::|
Mouse  1218 KLQEIRKYYMSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSP 1273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392	29/93 (31%)
		ARID	299..381	CDD:279697	35/81 (43%)
		Tudor-knot	692..751	CDD:288553	24/60 (40%)
Arid4a	XP_036013289.1	Tudor_ARID4A_rpt1	4..61	CDD:410530	31/59 (53%)
		Tudor_SF	62..118	CDD:413384	35/56 (63%)
		RBB1NT	170..262	CDD:400474	30/97 (31%)
		ARID_ARID4A	312..397	CDD:350646	36/84 (43%)
		CBD_RBP1_like	580..638	CDD:350843	26/61 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848700
Domainoid	1	1.000	180	1.000	Domainoid score	I3492
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	447	1.000	Inparanoid score	I1616
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003167
OrthoInspector	1	1.000	-	-		otm43501
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13964
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	1	1.000	-	-		X2560
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.970