DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htk and Arid5a

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	NP_001277655.1	Gene:	Arid5a / 214855	MGIID:	2443039	Length:	619	Species:	Mus musculus

Alignment Length:	688	Identity:	132/688 - (19%)
Similarity:	218/688 - (31%)	Gaps:	199/688 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 NISSDDEGEID----SDSSDDE------------------PHEEKDRFVAQLYKYMDDRGTPLNK 317
            |....:||::.    |...|||                  ..||:..|:..|||:|.:|.||:.:
Mouse    38 NTEQSEEGDLPQLPVSPKPDDEQSRSQSPTQLQDSPEAGGEQEEEQAFLVSLYKFMKERHTPIER 102

  Fly   318 VPSILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPCTVSVMNLVKQAYKKFLQPYG 382
            ||.:..:.::|:::::||:|.|.|..||.:..||.:...||.:|.:.|.....::.|::.:.||
Mouse   103 VPHLGFKQINLWKIYKAVEKLGAYELVTGRRLWKNVYDELGGSPGSTSAATCTRRHYERLVLPY- 166

  Fly   383 DFHRKLGCSMLMTSRNSNRSKGRSLVRANSVASPKPMETMK-----------------TETISKL 430
                                     ||.......||:...|                 ||.:.|.
Mouse   167 -------------------------VRHLKGEDDKPLPPTKPRKQYKMAKELRGDDGTTEKLKKA 206

  Fly   431 AQPNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEESGNTSESSVVVEPPKKQRKGSAAS 495
            ....:..|..:|.....:.:...:..|.:.   :|:.:.|:.|..|..|    ||.     :.||
Mouse   207 KDSEERRVEQTTPGKTKSDATGQTQLPCQG---SSRDSTEQLGPVSGPS----PPL-----TGAS 259

  Fly   496 SQQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTATNLSSATSGGSATIA 560
            |.....|.|:..:..|             |:....|..|.....|..|.|..|.....|  ....
Mouse   260 SCPEAYKRLLSSFYCK-------------GAHGIMSPLAKKKLLAQVSKAEALQCQEEG--CRHG 309

  Fly   561 TTAMNKDAESDLPLAKIKAAAVAAASTRHSMEKETNISSGSSASASSKANSAEMQRSRDASPSVA 625
            ..:.|||.: |.| ..::..|       .:.|.:.....|..|...|....|::      .|...
Mouse   310 ARSPNKDIQ-DSP-QNLRGPA-------ENSEHQLTPREGLQAPGGSTRMEAQV------GPCPT 359

  Fly   626 APPSAGASTSGAAATAQTASNKKEKHQRSKQADKEKDKDKEEKQASSGKRKKEKISVEKIDTGDF 690
            ||..:|...:......:..|    :|.|                                   ||
Mouse   360 APMFSGCFHAYPTEVLKPVS----QHPR-----------------------------------DF 385

  Fly   691 VVGIGDKLKVNYHEKK-------------SPSSHGSTYEAKVIEISVQRGVPMYLVHYTGWNNRY 742
            ..|:.|::.:....|:             ..::|.|.:         .:|           :.|.
Mouse   386 FSGLKDRVLLGPPGKEEGPTTKESHLVWGGDANHPSAF---------HKG-----------STRK 430

  Fly   743 DEWVPRERIAENLTKGSKQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGGGSLLVQGSQPPGVS 807
            ..:.|:.: |..::..:|..|......|.:..|.|.|...|....|...||..|.........|.
Mouse   431 RSFYPKPK-ACWVSPMAKVPTERPGAPSPHPSSPGLGSKRGLEEEGFAHGGKKLRAVSPFLKEVD 494

  Fly   808 DKQPGKDGCSKMSPSSGNSTGPG--APSLSGSLGGASSTPSLLSTVVKTPP--TGGAKRGRGRSD 868
            .|:.|           |....||  ...|.|...|.:...:...|:::.|.  ||.|...:|::
Mouse   495 SKETG-----------GKPAAPGLAVSCLLGPTPGPTPPEAYRGTMLRCPLNFTGSADPLKGQA- 547

  Fly   869 SMPPRSTTPSSVVAHSGRTKSPAASQPQLQQQMKKRPT 906
            |:|   .:|..:.|......:...|.|.....|...||
Mouse   548 SLP---FSPLVIPAFPAHLLATTGSSPMAASLMHFPPT 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392
		ARID	299..381	CDD:279697	25/81 (31%)
		Tudor-knot	692..751	CDD:288553	8/71 (11%)
Arid5a	NP_001277655.1	ARID_ARID5A	85..167	CDD:350648	27/107 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848698
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.770