DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htk and ARID3C

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	NP_001017363.1	Gene:	ARID3C / 138715	HGNCID:	21209	Length:	412	Species:	Homo sapiens

Alignment Length:	339	Identity:	83/339 - (24%)
Similarity:	123/339 - (36%)	Gaps:	80/339 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 EENIGKVVCVETESKKKDKEKWFPALVVAPTAQATVRIRVKDEYLVRSFKDGRYYTVPKKEATEF 236
            |..:|.|...|.|..::|:||                               |.....::||.|.
Human    42 EGALGNVGAEEEEDAEEDEEK-------------------------------REEAGAEEEAAEE 75

  Fly   237 TREVASKQDVPAVQAALEFLDSSVLPAHWDRDSLFGLTNISSDDEGEIDSDSSDDEPHEEKDRFV 301
            :|..|.....|:.|      ...:.|..|..:..|       ....|:|:|       .::..|:
Human    76 SRPGAQGPSSPSSQ------PPGLHPHEWTYEEQF-------KQLYELDAD-------PKRKEFL 120

  Fly   302 AQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPCTVSV 366
            ..|:.:|..||||:|:||.:..:.:|||.|||.|..:||...|.::..|:.:...|.......|.
Human   121 DDLFSFMQKRGTPVNRVPIMAKQVLDLYALFRLVTAKGGLVEVINRKVWREVTRGLSLPTTITSA 185

  Fly   367 MNLVKQAYKKFLQPYGDFHRKLGC-SMLMTSRNSNRSKGR----SLVRANSVASPKPMETMKTET 426
            ...::..|.|:|.||....|.|.. ..|..:.:|||.:||    :......:|.|.|........
Human   186 AFTLRTQYMKYLYPYECETRALSSPGELQAAIDSNRREGRRQAYTATPLFGLAGPPPRGAQDPAL 250

  Fly   427 ISKLAQPNQTNVVASTSSSAAAASVAASSTPARAVSTASQS--AAEES---------------GN 474
            ....|.|       :|.||...|..:.|..||.|.:..|.|  ..|||               |.
Human   251 GPGPAPP-------ATQSSPGPAQGSTSGLPAHACAQLSPSPIKKEESGIPNPCLALPVGLALGP 308

  Fly   475 TSESSVVVEPPKKQ 488
            |.|.....|||:|:
Human   309 TREKLAPEEPPEKR 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392	16/89 (18%)
		ARID	299..381	CDD:279697	26/81 (32%)
		Tudor-knot	692..751	CDD:288553
ARID3C	NP_001017363.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96		16/90 (18%)
		ARID	101..227	CDD:355778	40/139 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..278		12/52 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840