DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htk and htk

DIOPT Version :10

Sequence 1:NP_573330.3 Gene:htk / 32877 FlyBaseID:FBgn0085451 Length:2486 Species:Drosophila melanogaster
Sequence 2:XP_061502837.1 Gene:htk / 1269724 VectorBaseID:AGAMI1_000086 Length:2575 Species:Anopheles gambiae


Alignment Length:2977 Identity:950/2977 - (31%)
Similarity:1287/2977 - (43%) Gaps:899/2977 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MQQMDDPPSLPVGTEVSAKYKGAFCEAKVSKVVRNIKVKVAYK-QGLGSGIVSDDAIKAPTGQLR 64
            |||:||||.|.||||||||||||||||||.|||||||.||||| ||||||:||||.||   |.||
Mosquito     1 MQQVDDPPYLTVGTEVSAKYKGAFCEAKVRKVVRNIKCKVAYKQQGLGSGVVSDDQIK---GALR 62

  Fly    65 VGAVVEVRHPDRKELVEATITKIQDCSQYTVVFDDGDITTLRRTALCLKSGRHFNESETLDQLPL 129
            |||.|||:||:|||.||||:|||||||||||||||||||||||:|||||||||||||||||||||
Mosquito    63 VGATVEVKHPERKEYVEATLTKIQDCSQYTVVFDDGDITTLRRSALCLKSGRHFNESETLDQLPL 127

  Fly   130 THPEHFGNPVVGGRRGRRRGHLNEDSSEDDDE---SDAKEVVNEKEENIGKVVCVET-ESKKKD- 189
            ||||||||||:|||||||..||..|.|.|:::   :.::...::||||||||||||| ::|||: 
Mosquito   128 THPEHFGNPVIGGRRGRRSRHLLPDESSDEEDEPTTHSRSNASDKEENIGKVVCVETSDNKKKNP 192

  Fly   190 KEKWFPALVVAPTAQATVRIRVKDEYLVRSFKDGRYYTVPKKEATEFTREVASKQDVPAVQAALE 254
            ||.|||.||||||||.|||||||||||||||||||||||||||||||||:..:|.:..||.||:|
Mosquito   193 KENWFPGLVVAPTAQDTVRIRVKDEYLVRSFKDGRYYTVPKKEATEFTRDSVNKSEAAAVSAAIE 257

  Fly   255 FLDSSVLPAHWDRDSLFGLTNISSDDEGEIDSDSSDDEPHEEKDRFVAQLYKYMDDRGTPLNKVP 319
            ::|:.|||.||||::|||.:...||.:.|:::|||||||.||||.|||||||:||||||||||.|
Mosquito   258 YMDNDVLPPHWDREALFGTSGSCSDSDQELETDSSDDEPTEEKDHFVAQLYKFMDDRGTPLNKAP 322

  Fly   320 SILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPCTVSVMNLVKQAYKKFLQPYGDF 384
            ||.:||||||||||||||..||||||||||||.||:||||:|.|.|:.|||||||||||..:.:|
Mosquito   323 SITNRDVDLYRLFRAVQKLHGYNRVTSQNQWKQIALRLGFSPATASITNLVKQAYKKFLFSFEEF 387

  Fly   385 HRKLGCSMLMTSRNSNRSKGRSLVRANSVASPKPMETMKTETI-SKLAQPNQTNVVASTSSS--- 445
            :|||||:|:...:.| |:||||||||:||.|||..|..|..|. .|.|.....:..|..|||   
Mosquito   388 NRKLGCTMVPHPKTS-RTKGRSLVRASSVQSPKLPEKEKLLTAKEKAASVAAADASAKASSSSAA 451

  Fly   446 -----AAAASVAASSTPARAVSTASQSAAEESGNTSES----SVVVEPPKKQRKGSAASSQQGKV 501
                 |||||.||::..|.|.:.||.||.|||||||||    |.|:.|...:||...     |||
Mosquito   452 AAAAAAAAASAAAAAAAAAAATEASNSAVEESGNTSESSAAESAVLRPSSTKRKVGG-----GKV 511

  Fly   502 KSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTATNLSSATSGGSATIATTAM-- 564
            |:||:|:|||........|....|.|.|:.::.......:.:.|:.......||.|..|.|.:  
Mosquito   512 KALVDKFEEKEKERDKEKSVGKGGGGESSGSSGGSKKEESVTPASAKKEKQLGGKAKPAETTVVE 576

  Fly   565 -----NKDAESDLPLAKIKAAAVAAASTRHSMEKETNISSGSSASASSKANSAEM------QRSR 618
                 .|||:|              ..::.. |:||..:.|||||....:::.:.      .|..
Mosquito   577 KRGRKRKDADS--------------VDSKKD-ERETTATGGSSASTGGASSNVKQDKHPASSRKE 626

  Fly   619 DASPSVAAPPSAGASTSGAAATAQTASNKKEKHQRSKQADKEKDKDKEEKQASSGKRKKEKISVE 683
            |..|    |.|......|...::...|.                      ..|.|.|   .||..
Mosquito   627 DGGP----PNSGSGGGGGGGGSSGNGSG----------------------PGSGGGR---SISPG 662

  Fly   684 KIDTG----DFVVGIGDKLKVNYHEKKSPSSHGSTYEAKVIEISVQRGVPMYLVHYTGWNNRYDE 744
            ...:|    ||.:.:||||||.|.|:|      .|||||||||:.|.|.|:|||||||||.||||
Mosquito   663 SAVSGGTVPDFPIEVGDKLKVYYDEQK------VTYEAKVIEIAKQEGNPIYLVHYTGWNTRYDE 721

  Fly   745 WVPRERIAENLTKGSKQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGGGSLLVQGSQPPGVSDK 809
            ||.:||||||||....:|                                               
Mosquito   722 WVRKERIAENLTNSKTKK----------------------------------------------- 739

  Fly   810 QPGKDGCSKMSPSSGNSTGPGAPSLSGSLGGASSTPSLLSTVVKTPPTGGAKRG--RGRSDSMPP 872
              ||        ||||:...|.||...:  .:|:..|.|:...|||..|...||  :|...|.|.
Mosquito   740 --GK--------SSGNTPTAGGPSTKQA--SSSNAGSTLTAGDKTPKIGKRSRGNSKGEQSSGPG 792

  Fly   873 RSTTPSSVVAHSGRTKSPAASQPQLQQQMKKRPTRVVPGTT-------TPRRVSDASMASE---- 926
            .::||.|...:.||.||||.  |..::.:.:..:....|::       ..||.|:.:..|.    
Mosquito   793 GNSTPRSTTPNVGRNKSPAT--PSNRRPLTRGGSSAATGSSLSASAAAAGRRTSNNTDISSSLSV 855

  Fly   927 -------SDSDSDEPVRRPKRQSAKDKPQAGKAQPPGKGRLASSASSTAPAAHPSDDSEEDEEEE 984
                   ||:|||||:.:....::                .:|:.||.:..:..|..::.....|
Mosquito   856 PTDPDNTSDTDSDEPMLKKCTTNS----------------TSSTTSSNSSISISSTSTKVSTTAE 904

  Fly   985 EPSAARAASSKQQQQQASSLRGSRAGGNRAMSSGAASAKGRDYDLSEIRSELKGFQPKLLTNAAS 1049
            ..|::.||:...:..     .|:..|....:..|.... ||||||::||||||||:......:.:
Mosquito   905 AGSSSDAAAISDEFS-----NGASKGVGGGVGVGGVGG-GRDYDLNQIRSELKGFKELKSPGSPA 963

  Fly  1050 NE------ERKDLAKKEPSDEPALQDI------KKEPKL------ESSAKSSST----------- 1085
            ::      .....|:..|:...::.|:      |:||.|      :.|..||:|           
Mosquito   964 SDTTTTTTTTAGAAEGGPNSSSSITDVPKHLIPKQEPNLLSTTDVKESVSSSNTPLATIKKELAA 1028

  Fly  1086 ------------------ELSSETESYADED-SQSSD---------------------------- 1103
                              |.|||:|:.::|| ||||:                            
Mosquito  1029 AVPIKEEESTVTEEDDEPEKSSESETLSEEDSSQSSNKAFSSSPITTMVDSDTAETPLAAGLVLS 1093

  Fly  1104 -------------------------------------------YRKQLKGSGAG-KKEPTAS--- 1121
                                                       .:|:|...||| :|.|:||   
Mosquito  1094 PKISSPPPSVERDDSSSTEPLITVASKAADAKAASLEKAAAASSKKELAEGGAGTEKAPSASATS 1158

  Fly  1122 ---PSKLHHEPVT------------------KREL-----------AVKEEPLKIEP-------- 1146
               |.|.:....|                  :.||           :|:|.|.|..|        
Mosquito  1159 GKPPVKTYGTAATIIANSEKMAFCTVRDAGSESELIIQPNAAAPKESVQESPQKNLPHPTPQTVG 1223

  Fly  1147 ---------KTEPKEEETKSKPFLSGADIKP---------TALIAPAR--FGNTSAAQAASSSGS 1191
                     ||..|||:   ||.:......|         |:.:.|.:  ||.:.:|.|:::|..
Mosquito  1224 MSPSLPARTKTGQKEED---KPAVGSVMTSPSSTASRTSGTSSLTPVKACFGASPSATASNNSKE 1285

  Fly  1192 SSTTAKYTSVIVEKPLTIGGKKSVEQHVPKKAELLKKQSGGAGGTAASSSAASQESKKFAEPVAS 1256
            .||.|...|||:...:   |.::::.  ||.:.          .||..|:||..|.|        
Mosquito  1286 ESTIASSQSVIMAAGM---GTRAIKS--PKSSP----------STATQSTAAPDEGK-------- 1327

  Fly  1257 LKVEMPAACSPSSSSSSSSSFCSTGSAVSSSSATRSLPDMSKLEISSGTVPGAT----------P 1311
                 ||..:...:|..:.:..|.||       .|.......|:. |||.|..|          .
Mosquito  1328 -----PATSTGGPASVQTPTITSFGS-------LRGDKKQGSLQY-SGTGPTGTGMERKFILGRE 1379

  Fly  1312 GAAAL-QPSNVAQVSSSGAAKESKYSSSGGAAAGS---------GISMRKLLS------------ 1354
            |::|. .|||.|...|:.:|.:......||...|.         ..:..||||            
Mosquito  1380 GSSAFSSPSNTASAQSALSAAQPTPKHGGGGLLGEKKHFSSSTLTPAQNKLLSKEALSIKSIFES 1444

  Fly  1355 ---------SDVYEFKDTEPFEFEKRISPMASVGGTVAAAATAAGA-------MAAAGAASVITT 1403
                     ||||||:|    |::.:.:...::||..:|:.||:|.       ::....|.|:::
Mosquito  1445 TANRMDEKISDVYEFED----EYDDQDTGSGALGGVGSASGTASGGATVPRKLVSDVPPAEVVSS 1505

  Fly  1404 MVPTPGASGSGVAASASTSAPVVVGSAARKQALKASAIQHILEHQSPAAGRERGGYGGMTSSISL 1468
            :..||.|: |..|.......|:      :::::.||::...|:    ..|...|||.        
Mosquito  1506 LSLTPSAA-SSTATDEKRKKPL------QRKSMAASSLPDPLD----TTGFGTGGYS-------- 1551

  Fly  1469 LTAPKLKKRGSPLKE-------------AALCMEKAKTYKLDKDQVQQPVEQKT----QQLIQPT 1516
             .|.|..|:.||:|.             |...:.:....|.||:| :.|||.:|    .::.:.|
Mosquito  1552 -PATKRAKKPSPMKPEPPAGSENKSPKGAGGLLRRETKEKEDKEQ-KLPVEAETAAPSAEVHRTT 1614

  Fly  1517 LGPVESYGAGSPEAMSNLSTPTTSSGHAQLSASSTYSQLTPHHATP------FDALRKSPSFNLN 1575
            :     |.|.:.:..|.:....|.:|...::..|.....|....||      ||.||||||||| 
Mosquito  1615 I-----YSAEALKEKSTVKVAATPAGPPVVTTCSPVGLTTAFVQTPVKSDSTFDVLRKSPSFNL- 1673

  Fly  1576 IT----ALNEELAQTVQETTRALTDALQPPSTPVPPTVSASGSTPTAVTPVITAMPTAGTAGLSC 1636
            :|    ...||..::..|.          .:.|.||.:.|: :||...||||:| .:||:.|:. 
Mosquito  1674 VTPGPLGAKEETFKSQDEI----------ETKPTPPPLPAT-TTPGIFTPVISA-SSAGSGGVG- 1725

  Fly  1637 PSTPPTGANPVLASPKLSTPPQAINASKQPPASHIVGSPFIETRNVFELSTSNEGSGYS------ 1695
                                .::|:::..|                       .|.|.|      
Mosquito  1726 --------------------DRSISSALYP-----------------------HGKGPSTSVLLA 1747

  Fly  1696 -SGESKDNKFEKLENVKILLAGAVGPFDLDAGSYEQKTSSIADKVLKAISQKKEEVENN------ 1753
             :|:....:...|||.|......  .|:.||.:. :|..|||||||||:||::::.:..      
Mosquito  1748 KAGDDSPKEEPTLENCKKYFNDM--NFEFDAPTV-KKPPSIADKVLKALSQQQQQQQQQQQQQQA 1809

  Fly  1754 -KGKPPVEPAAAAKTPGREDVVPSPTAKLD---LCSSAIKLDT-LKLLSEPLKIQTGPLLGELYR 1813
             |.:.|..|...:.......:..:|.:.::   |.|.|::..| :...|.|........:|.:..
Mosquito  1810 IKSEKPEFPKYMSSVMHHHSLPSTPKSIMNSGLLSSPAMESGTPMSFASAPHPAIKSEAIGSIGG 1874

  Fly  1814 PGPATSSPETKSILESSLPAKNSELSETI------QKLECAIQQRKTPVGGALSLASST------ 1866
            ....|.|..|.|:..|..|:....||..:      .:....:..:|.|.....|:..|.      
Mosquito  1875 SIATTISSYTSSVTVSGPPSNAGYLSNEVLSSAKSHETSTTLGMKKEPEESHNSIVKSAPISTTD 1939

  Fly  1867 ------AGTPPTAH------TPNSTATAGA------------------------------GFSDE 1889
                  ..|||::.      ||..|.|.|.                              ...||
Mosquito  1940 PKTNHPPQTPPSSSSSSSITTPTPTNTGGGHKLHTLEQIPTSRSNDLTETLRKLDPDPRFAHDDE 2004

  Fly  1890 SMDSTDSEQRLVIEDVIAEEHTTTTTTGEQKSPGSQQEEGQTNTATMATAVTAETEGTSSSTPTP 1954
            |.||.||:.||:|||                                     ||::|  |..|.|
Mosquito  2005 STDSNDSDNRLIIED-------------------------------------AESQG--SGDPVP 2030

  Fly  1955 PVPA---PVKLELGAKAMPGIQAPIPLKPAEGSSFAGKLTGVVQPPPLAKLQQQEELGQAQGQSK 2016
            .|||   |......:.|.|...|.|....::            ||.|.:.:..::||.:.:.:|.
Mosquito  2031 SVPAAHPPPAAITSSAATPSTAAVIVHYDSK------------QPVPSSVISAKKELFEERPRST 2083

  Fly  2017 SISSFGIPIVLPEIPASVVVATPALMVASAATVMRHSPGSTPNSQAPVLISPKTFLTAPKVGEVG 2081
            :.||......:....||...|.....||....::      ....:||...:..| :|.....:..
Mosquito  2084 AASSSSSSSSITHEMASAASAAAVAAVADKEKLI------LKQDRAPTTTTTTT-ITPDTPSQTK 2141

  Fly  2082 GLLLKAYTGVSGAVGAAPAGSVIASAGGGGTPTVISNFPQ-------------------QQQQAS 2127
            ...:|..:|||     |||.:|......|...:::....|                   :|||:|
Mosquito  2142 EEPVKPLSGVS-----APATTVEKKTSSGAKQSLLETIIQMNTPGRGMSSEEYLMHKVHEQQQSS 2201

  Fly  2128 VLQASSEMPANYVLDAEMAEPSNSSAPVVARPFVMHAVGKELFNVVAPAASSPLISD-------- 2184
            .:|..:|...:....|:....| .:.|.........|.|.       |.|||...|.        
Mosquito  2202 SVQRDAESRKDAAATAQKLHDS-GAVPASTSVITSTASGD-------PVASSTTQSPKQEQHNAQ 2258

  Fly  2185 -----PHNESIN-LLCEETIPGSPAPN--------------YGGTDQLPTAVNSALA-------- 2221
                 |:|||:: |||||||||||||.              |.....:||:.:|:.:        
Mosquito  2259 SQAQAPNNESLSLLLCEETIPGSPAPKDQDRLPPSTVGRKVYAEPPLVPTSTSSSSSSFLPPQNI 2323

  Fly  2222 --IVGITPLPPDTPPPVPVAAI----------------------QQQQQHQLQSGQQQQAAKTGE 2262
              ...:.|:|.|..|||....|                      |||||.|.|  ||||.|...:
Mosquito  2324 QTATDLKPVPMDLEPPVVTITIGGNTTISSTSQSGAAGAYASNLQQQQQQQQQ--QQQQQALRNK 2386

  Fly  2263 VNPSG-------PNSSP-DSASQDESGEEAKKNAGLEHEDSTGLGALNKRKRNRKPLPMSAQTAA 2319
            :|.||       ||||| ||.||||:.         :||..:.:    |::|.|||         
Mosquito  2387 INTSGVESTVDTPNSSPRDSVSQDETH---------DHESLSPV----KKRRQRKP--------- 2429

  Fly  2320 AVAAQLQSLGKRRRQV-----------------SGM-RNQKTTTTAAGSDTDDNSDNIAPNAGQQ 2366
               ::..:| ||||.|                 ||. |:|:..||:..:|::||||.|       
Mosquito  2430 ---SEEPTL-KRRRTVNTSLGGYGSANNGSNSGSGYGRSQRGLTTSNATDSEDNSDTI------- 2483

  Fly  2367 QQQPRQSARQHMMPQSNAQQQQQQQLLQQQQTQLPQGIQSTNSSGVRPCPYNFLVELDPALSSDE 2431
                   |..|....|.                    :....|...|||.|||||.|||:|:|::
Mosquito  2484 -------AAFHRSSSST--------------------LIFVGSKTGRPCQYNFLVNLDPSLNSNQ 2521

  Fly  2432 CITILRKQIQDLRKAYNTIKGELAVIDRRRKKLRRRERE-KKQQQLQSQQQG 2482
            .|.|::|:||:|||.||:||.|||.|||||||||||||| |||.:|.|...|
Mosquito  2522 RIVIIKKKIQELRKTYNSIKAELASIDRRRKKLRRRERENKKQAKLNSASAG 2573

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htkNP_573330.3 Tudor_ARID4_rpt1 10..60 CDD:410460 43/50 (86%)
Tudor_ARID4_rpt2 65..118 CDD:410461 46/52 (88%)
RBB1NT 170..263 CDD:462390 71/94 (76%)
ARID 296..381 CDD:460187 69/84 (82%)
CBD_RBP1_like 698..758 CDD:350843 41/59 (69%)
htkXP_061502837.1 None

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