Protein Alignment htk and ARID5A

DIOPT Version :10

• Sequence 1: NP_573330.3
• Gene: htk / 32877
• FlyBaseID: FBgn0085451
• Length: 2486
• Species: Drosophila melanogaster
• Sequence 2: XP_016858672.1
• Gene: ARID5A / 10865
• HGNCID: 17361
• Length: 657
• Species: Homo sapiens
• Alignment Length: 714
• Identity: 130/714 - (18%)
• Similarity: 207/714 - (28%)
• Gaps: 300/714 - (42%)

  Fly   272 GLTN-ISSDDEGEIDSDSSDDEPHEEKDRFVAQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAV 335
            |:.| ||.:|..|...:..:::..||:..|:..|||:|.:|.||:.:||.:..:.::|:::::||
Human    42 GIQNPISLEDSPEAGGEREEEQEREEEQAFLVSLYKFMKERHTPIERVPHLGFKQINLWKIYKAV 106

  Fly   336 QKRGGYN-----------------------------------------------------RVTSQ 347
            :|.|.|.                                                     :||.:
Human   107 EKLGAYELSMALGERIGWPLLEPQSSCQTAVLRVPARAAGAARTPPPGGARRPRPHEVPLQVTGR 171

  Fly   348 NQWKLIAMRLGFTPCTVSVMNLVKQAYKKFLQPYGDFHRKLGCSMLMTSRNSNRSKGRSLVRANS 412
            ..||.:...||.:|.:.|.....::.|::.:.||                          ||...
Human   172 RLWKNVYDELGGSPGSTSAATCTRRHYERLVLPY--------------------------VRHLK 210

  Fly   413 VASPKPMETMKTETISKLAQPNQTNVVASTSSSAAAASVAASS-TPARAVSTASQSAAEESGNTS 476
            ....||:.|.|.....|:|:.|:.:..|:.....|........ .|.:..:.|:..|...|
Human   211 GEDDKPLPTSKPRKQYKMAKENRGDDGATERPKKAKEERRMDQMMPGKTKADAADPAPLPS---- 271

  Fly   477 ESSVVVEPPKKQRKGSAASSQQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAA 541
                 .|||:.      ::.|||                 ..|..:|:..|||....|....
Human   272 -----QEPPRN------STEQQG-----------------LASGSSVSFVGASGCPEAYKRL--- 305

  Fly   542 ASTATNLSSATSGGSATIATTAMNKDAESDLPLAKIKAAAVAAASTRHSMEKETNISSGSSASAS 606
                  |||....|:..|.:....|...:.  ::|::|........||..|.:
Human   306 ------LSSFYCKGTHGIMSPLAKKKLLAQ--VSKVEALQCQEEGCRHGAEPQ------------ 350

  Fly   607 SKANSAEMQRSRDASPSVAAPPSAGASTSGAAATAQTASNKKEKHQRSKQADKEKDKDKEEKQAS 671
                         |||:|..|.|. .|..|.        .:..:|:.:.|         |..||.
Human   351 -------------ASPAVHLPESP-QSPKGL--------TENSRHRLTPQ---------EGLQAP 384

  Fly   672 SGKRKKE----KISVEKIDTGDFVVGIGDKLK-VNYHEKKSPSSHGSTYEAKVIEISVQRGVPMY 731
            .|..::|    ......|..|.|.....:.|| |:.|
Human   385 GGSLREEAQAGPCPAAPIFKGCFYTHPTEVLKPVSQH---------------------------- 421

  Fly   732 LVHYTGWNNRYDEWVPRE---RIAENLTKGSKQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGG 793
                           ||:   |:.:.:..|
Human   422 ---------------PRDFFSRLKDGVLLG----------------------------------- 436

  Fly   794 GSLLVQGSQPPGVSDKQPGKDGCSKMSPS---SGNSTGPGAPSLSGSLGG---ASSTPSLLSTVV 852
                            .|||:|.|...|.   .|::..|.|....||..|   .......:|.:.
Human   437 ----------------PPGKEGLSVKEPQLVWGGDANRPSAFHKGGSRKGILYPKPKACWVSPMA 485

  Fly   853 KTPPTGGAKRGRGRSDSMPPRSTTPSSV------------VAHSGRTKSPAASQPQLQQQMKKR 904
            |.|         ..|.::||  |.|||.            .||||  |...|..|.|::...|:
Human   486 KVP---------AESPTLPP--TFPSSPGLGSKRSLEEEGAAHSG--KRLRAVSPFLKEADAKK 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	Tudor_ARID4_rpt1	10..60	CDD:410460
		Tudor_ARID4_rpt2	65..118	CDD:410461
		RBB1NT	170..263	CDD:462390
		ARID	296..381	CDD:460187	26/137 (19%)
		CBD_RBP1_like	698..758	CDD:350843	7/63 (11%)
ARID5A	XP_016858672.1	ARID	71..206	CDD:355778	27/160 (17%)
		PHA03247	<141..449	CDD:223021	80/513 (16%)