DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htk and arid5b

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	XP_017214107.1	Gene:	arid5b / 100536827	ZFINID:	ZDB-GENE-121214-272	Length:	1079	Species:	Danio rerio

Alignment Length:	805	Identity:	151/805 - (18%)
Similarity:	286/805 - (35%)	Gaps:	166/805 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 DSLFGLTNISSDDEGEIDSDSSDDEP--------HEEKDRFVAQLYKYMDDRGTPLNKVPSILSR 324
            ||..|::...:...|......|:::|        ..::..|:..|||||.:|.||:.::|.:..:
Zfish   213 DSKSGVSKPRNPSTGSCKRVQSENKPKGDGGDECRTDEQAFLVALYKYMKERKTPIERIPYLGFK 277

  Fly   325 DVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPCTVSVMNLVKQAYKKFLQPYGDFHRKLG 389
            .::|:.:|:|.||.|||..:|::.|||.:...||..|.:.|.....::.|::.:.||..|.:...
Zfish   278 QINLWTMFQAAQKLGGYEVITARRQWKNVYDELGGNPGSTSAATCTRRHYERLILPYERFTKGEE 342

  Fly   390 CSMLMTS--RNSNRSKGRSLVRANSVASPKPMETMKTETISKLAQPNQTNVVASTSSSAAAASVA 452
            ...|..:  |....|...|:::|..:...:|.:..||....|.|.
Zfish   343 DKPLPPAKPRKQEGSVQESIIKAKMMPIKRPKDEQKTPRGDKDAS-------------------- 387

  Fly   453 ASSTPARAVSTASQSAAEESGNTSESSVVVEPPKKQRKGSAASSQQGKVKSLVEKYEEK---STA 514
                 |:.:....:. .||......|..:..|.:..|..::..::..: ..||.|.|::   ..|
Zfish   388 -----AKVLELGMED-MEELQEKQNSQQLQAPTQTDRDPNSPLTEDDE-GVLVIKDEDQPVLHNA 445

  Fly   515 VQATSSG---TVAGSGASASA--------AAMP-------------------------TTSAAAS 543
            .:..:.|   ::...||...:        ||:|                         ..||.|:
Zfish   446 YEHANGGLLPSLPQDGAQLKSEDCDAFPVAAVPLHHGHPLPNSHTSDQWKHGILEYKVPPSALAN 510

  Fly   544 TATNLSSATSGGSATIATTAMNKDAES-DLPLAKIKAAAVAAASTRHSMEKETNISS-------- 599
            ...:...........:..|...|...| ::|..:::           .::||.:..:
Zfish   511 VEQSRPKEGQNQVVMVLPTLQQKPVTSPEIPPERVE-----------PLKKEESCFNFNPLLYPR 564

  Fly   600 GSSASASSKANSAEMQR-------------------SRDASPSVAAPPSAGASTSGAAATAQTAS 645
            |:....|..|....:.:                   ||..|.|.....|||.|:|..:::.:|:.
Zfish   565 GNPGIMSPLAKKKMLSQVSGTGLLNNYPYGPPPPLVSRRLSSSGTEVSSAGQSSSQVSSSVETSI 629

  Fly   646 NKKEKHQRSKQADKEKDKDKEEKQASSGKRKKEKISVEKIDTGDFVVGIGDKLKVNYHEKKSPSS 710
            ..| :....:.|...|.:..|::::|:...:|:..|     .|:.|......::..|.::..|
Zfish   630 VIK-RPSVIQHAQSFKSRGSEDRRSSTEGSQKDGCS-----EGEPVHHSQTLIREPYLKRVDP-- 686

  Fly   711 HGSTYEAKVIEISVQRGVPMYL------VHYTGWNNRYDEWVPRERIAENLTKGSKQKTRTISTS 769
            |.|.  .|..|:......|.:|      .|......:.:..:.:|:|       ||..:|.:.|.
Zfish   687 HSSM--EKSAEMPRPGQAPSFLSEFYSSPHLHNLCRQTEHHLSKEQI-------SKYLSRDVYTR 742

  Fly   770 SANSGSGGGGGGGGGGGGGGGGGGGSLLVQGSQPPGVSDKQPGKDGCSKMSPSSGNSTGPGAPSL 834
            .:.:..|..........|.......|...:|..|..|:::||......|.||..       .|..
Zfish   743 DSETAQGFPPSQHPDNVGLNFSARLSQKEKGPPPERVTEEQPTDLSLPKSSPLK-------LPLS 800

  Fly   835 SGSLGGASSTPSLLSTVVKTPPTGGAKRGRGRSDS---------MPPRSTTPSSVV--AHSGRTK 888
            :.:|||...  :.:...:|..|...|  |..:|.|         :||.:.:.|..|  :||...:
Zfish   801 TSTLGGIPH--AAIQQDIKNSPHFQA--GNSQSSSVDYHPRACRVPPMTVSASKKVTESHSKVLE 861

  Fly   889 SPAASQPQLQQQMK----KRPTRVVPGTTTPRRVSDASMASESDSDSDEPVRRPKRQSAKDKPQA 949
            ....|:.:.....|    .||  ::...::|:.:..|.....:..|.:......|.::......:
Zfish   862 KTPNSRGEESMGFKIDEMSRP--ILSTKSSPQNICTARPLKRNIEDLENGPTEKKIRAVTPLHCS 924

  Fly   950 GKAQPPGKGRLASSASSTAPAAHPS 974
            .:...|||.|...:.|.:...|.|:
Zfish   925 TQRDLPGKPRTPEADSESVKPAEPA 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392
		ARID	299..381	CDD:279697	27/81 (33%)
		Tudor-knot	692..751	CDD:288553	10/64 (16%)
arid5b	XP_017214107.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840