DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htk and arid5b

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	XP_002939588.1	Gene:	arid5b / 100485942	XenbaseID:	XB-GENE-1007579	Length:	1183	Species:	Xenopus tropicalis

Alignment Length:	1139	Identity:	215/1139 - (18%)
Similarity:	358/1139 - (31%)	Gaps:	345/1139 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 DSSDD-----EPHEEKDRFVAQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTS 346
            |..||     |...|:..|:..|||||.:|.||:.::|.:..:.::|:.:|:|.||.|||..:|:
Frog   312 DGEDDGYKVEEGKAEEQSFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYETITA 376

  Fly   347 QNQWKLIAMRLGFTPCTVSVMNLVKQAYKKFLQPYGDFHRKLGCSMLMTSRNSNRSKGRSLVRAN 411
            :.|||.|...||..|.:.|.....::.|::.:.||..|            .|....|...|.:
Frog   377 RRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERF------------INGEEDKPLPLTK-- 427

  Fly   412 SVASPKPMETMKTETISKLAQPNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEESGNTS 476
                |:..|....|...|:.       :..|                :.:....|...:|.....
Frog   428 ----PRKPENGPQEVDMKVK-------ICGT----------------KRIKNEPQKPKKEKDAKG 465

  Fly   477 ESSVVVEPPKKQRKGSAASSQQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTS-- 539
            .....|.|.::..       .:...|::...|:.:.|......|.:|      .|....|:.|
Frog   466 YDMAEVPPDEEDH-------LEADEKNMPFGYDSEETKTSVDKSESV------VSEVKYPSLSEN 517

  Fly   540 -AAASTATNLSSATSGGSATIATTAMNKDAESDLPLAKIKAAAVAAASTRHSMEKET-------N 596
             ....|..|....|....:.       :||:....|..:|.........|..|..||       .
Frog   518 DELEETIANQDHVTQDEDSC-------QDADPVDSLICVKEIDSRQTDERLQMPNETMTITKQEQ 575

  Fly   597 ISSGSSASASSKANSAEMQRSRDASPSVAAPPSAGASTSGAAATAQTASNKKEKHQRSKQADKEK 661
            |....|......|...::.    ..|:|..|                      :|
Frog   576 IKPDYSDHLEDDAEDVQLH----VFPAVQPP----------------------RH---------- 604

  Fly   662 DKDKEEKQASSGKRKKEKISVEKIDTGDFVVGIGDKL-KVNYHEKKSPSSHGSTYEAKVIEISVQ 725
              |.||          ||:.    |..|::.....|: .:...:.|:|      .::.:.:.:::
Frog   605 --DMEE----------EKLP----DMPDYIANCTVKMDPLGSSDLKNP------LDSNLFQNALK 647

  Fly   726 RGVPMYLVHYTGWNNRYDEWVPRERIAENLTKGSKQKTRTISTSSANSGSGGGGGGGGGGGGGGG 790
            :...:|||                              :|:
Frog   648 QNPKVYLV------------------------------QTL------------------------ 658

  Fly   791 GGGGSLLVQGSQPPGVSDKQPGKDGCSKMSP---SSGNSTGPGAPS------LSGSLGGASSTPS 846
                .:|.:...||.::|     |.....:|   |.||   ||..|      |...:.|||...:
Frog   659 ----DMLNEKEAPPSMND-----DSSFSYTPLLYSRGN---PGIMSPLAKKKLLSQVSGASQPGN 711

  Fly   847 LLSTVVKTPPTGGAKRGRGRSDSMPPRSTTPSSVVAHSGRTKSPAASQPQLQQQM----KKRPTR 907
            |  .....||....|:...:.:..|....|     .||..::|.|.::|.:.|.:    :|.|..
Frog   712 L--PYGSPPPLINKKKLSSKGEVSPSLLQT-----HHSSNSESVAINRPSVIQHVQSFKQKSPEE 769

  Fly   908 VVPGTTTPRRVSD---ASMASESDSDSDEPVRRPKRQSAKDKPQAGKAQPPGKGRLASSASSTAP 969
                   .:.|:|   .||..:.||...:..:.  :||.                ||.|.:..|.
Frog   770 -------KKTVNDHYKNSMFGKVDSYCCDFAKH--QQSV----------------LADSYALKAS 809

  Fly   970 AAHPSDDSEEDEEEEEPSAARAASSKQQQQQASSLRGS-------RAGGNRAMSSGAASAKGRDY 1027
            .         .|.:|:.:..||||:.......:....|       |...:...:..:|....|:.
Frog   810 I---------QECKEKMAEKRAASNSNVPSFLAEFYSSPHLHRLYRQTEHHLHNENSAKFHSREM 865

  Fly  1028 --DLSEIRSELKGFQPKLLTNAASNEERK----DLAKKEPSDEPALQDIKKEPKLESSAKSSSTE 1086
              ||..:.|     ..||..:|:.::..|    |:...:|:|   |...|...||.:....||..
Frog   866 FRDLENVSS-----SHKLHYHASLHQHDKQNLCDIVDDQPTD---LSLPKSLHKLATRIPGSSIA 922

  Fly  1087 LSSETESYADEDSQSSDYRKQLKGSGAGKKEPTASPSKLHHEPVT----KRELAVKEEPLK-IEP 1146
            ..|..:   |..|.:..:....|..|.     ..:|......|:|    ||.:.....|.| ::|
Frog   923 HHSVQQ---DAKSHNPFHTPNSKTLGV-----DCTPKACRVSPMTMSMPKRNMDSIHRPSKTLKP 979

  Fly  1147 KTEPKEEETKSKPFLSGADIKPTALIAPARFGNTSAAQAASSSGSSSTTAKYTSVIVEKPLTIGG 1211
            .|..|.|                .|:.|...|.||     :.:.....:.|.....::.|:|
Frog   980 DTVRKVE----------------GLVHPFSIGKTS-----TQNFGPPRSLKRNLEDLDHPVT--- 1020

  Fly  1212 KKSVEQHVPKKAELLKKQSG-----GAGGTAASS-----SAASQESKKFAEPVASLKVEMPAACS 1266
            :|.:....|  ..|.|:.||     |..|.::.|     |.:..||.|:  |::          |
Frog  1021 EKKIRAVSP--LSLPKEMSGKETFVGQDGESSKSVHDIHSGSMMESHKY--PLS----------S 1071

  Fly  1267 PSSSSSSSSSFCSTGSAVSSSSATRSLPDMSKLEISSGTVPGATPGAAALQPSNVAQVSSSGAAK 1331
            |........|.|   ..:||...|.....:..|:..:...|...|.|..........:::|..::
Frog  1072 PVFPGMYPGSLC---GGLSSRIPTAYSHPLQYLKNQTVLSPLMQPLALHTFMMQRQYLTNSTNSQ 1133

  Fly  1332 ESKYSSSGGAAAGSGISMRKLLSSDVYEFKDTEP 1365
            :.....:.||..||  |...||.:.:|......|
Frog  1134 QLYRQIASGAPVGS--SYGDLLHNSIYPLTAINP 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392
		ARID	299..381	CDD:279697	28/81 (35%)
		Tudor-knot	692..751	CDD:288553	6/59 (10%)
arid5b	XP_002939588.1	ARID_ARID5B	326..420	CDD:350649	33/105 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910