DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htk and arid5a

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	NP_001314703.1	Gene:	arid5a / 100462698	ZFINID:	ZDB-GENE-100525-3	Length:	587	Species:	Danio rerio

Alignment Length:	447	Identity:	98/447 - (21%)
Similarity:	177/447 - (39%)	Gaps:	79/447 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 DVPAVQAALEFLD------SSVLPAHWDRDSLFGLTNISSDDEGEIDSDSSDDEPHEEKDRFVAQ 303
            :|.|.:..||..:      :|....:.:.:||.. ||.|.|       :|..|:...|:..|:..
Zfish     8 EVDAAEGELEDCEKKNQELNSPNQTNGEMESLTS-TNSSED-------NSRSDQSESEERTFITN 64

  Fly   304 LYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPCTVSVMN 368
            ||.:|.:|.||:.::|.:..:.::|:::::||:..|||:.||::.|||.:...||.:|.:.|...
Zfish    65 LYCFMKERNTPIERIPHLGFKQINLWKIYKAVETLGGYDAVTARRQWKNVYDELGGSPGSTSAAT 129

  Fly   369 LVKQAYKKFLQPYGDFHRKL---GCSMLMTSRNSNRSKGRSLVRANSVASPKPMETMKTETISKL 430
            ..::.|::.:.|   |.|:|   ....|..|:...:.|.....|.:...|.|..:..:.|:..|:
Zfish   130 CTRRHYERLVLP---FERQLRGEEDKPLPPSKPRKQYKRSPENRGSKPESKKKRKMERDESEEKM 191

  Fly   431 AQPNQTNVVASTS------SSAAAASVAASSTPARAVSTASQSAAEESGNTSESSVVVEPPKKQR 489
            ...:..:....:.      ||....|...|:.|...:|:......:    ||....|:.|.:|::
Zfish   192 LSDHHCDRGRCSHHSPWLISSDRLDSEHTSTAPVLGMSSRENPLLQ----TSSPPEVISPLEKKK 252

  Fly   490 KGSAAS-----SQQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTATNLS 549
            :.:.||     |:.|      .:.|..|....:.||.:......|:..:.:|.:|.:.|.:.:.|
Zfish   253 RLAQASLTIPASEDG------GELERPSVIHISHSSQSNTRGRHSSDGSPVPVSSPSGSLSRSPS 311

  Fly   550 SATSGGSATIATTAMNKDAESDLPLAKIKAAAVAAASTRHSMEKETNISSGSSASASSKANSAEM 614
            ..:......||.|.....|:                      |.|...::...|.::|||
Zfish   312 PYSVSSEDCIAVTTQKSPAK----------------------EPENKTATRLPALSTSKA----- 349

  Fly   615 QRSRDASPSVAAPPSAGASTSGAAATAQ------TASNKKEKHQRSKQADKEKDKDK 665
                 .|..|..|.|...:|...|...:      ..:...||.|||..|....||.:
Zfish   350 -----VSTGVCKPLSCYPNTKELANYPRLHYREFLQAGATEKTQRSLLAWTSDDKSR 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392	5/22 (23%)
		ARID	299..381	CDD:279697	24/81 (30%)
		Tudor-knot	692..751	CDD:288553
arid5a	NP_001314703.1	BRIGHT	57..148	CDD:128777	29/93 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840