DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvf1 and pdgfbb

DIOPT Version :9

Sequence 1:	NP_523407.1	Gene:	Pvf1 / 32876	FlyBaseID:	FBgn0030964	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	XP_005171668.1	Gene:	pdgfbb / 796490	ZFINID:	ZDB-GENE-131121-332	Length:	483	Species:	Danio rerio

Alignment Length:	239	Identity:	53/239 - (22%)
Similarity:	96/239 - (40%)	Gaps:	50/239 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 LEGSCCQGAAAEAGTPLTLPL-------SVSA--ELTNVTADYDVSGEMPSSKENFKRSIMKSTV 134
            |..:|.:..:||| .||...:       |||:  :|..:.....:..|..|..:|...:.:..::
Zfish    12 LAAACLRFGSAEA-DPLPAAVVELVKAGSVSSIQDLQFLLFSESIEVEPDSHHDNDSSNRLPRSL 75

  Fly   135 RNATPAS---CSPQPTIVELKPPAEDEAN--YYYMPACTRISRCNGCCGSTLISCQPTEVEQVQL 194
            .:|.||.   |..:..::|:.....|.:|  :...|.|..:.||:|||.:..:.|.|.......|
Zfish    76 LDAQPAQQAICKVRTEVIEVTRSMLDRSNADFLLWPPCVEVQRCSGCCNTKTLQCVPVLTHTRYL 140

  Fly   195 RVRKVDRAATSGRRPF---TIITVEQHTQCRC-----------------DCRTKAEDCNVYQS-Y 238
            :|.|:....   :||.   .:::|..|.:|||                 |.|.::|.....:. :
Zfish   141 QVMKIQYVK---KRPLYDKAVVSVLDHVECRCQPAPRPAHRRKSSSQKLDARDRSEKSRPKEDLH 202

  Fly   239 RKDLCRCECHNTDARDKCLEQAENKYWVDDNCTCVCRYNQSCTT 282
            |:|..:   ||....   ||...:..|:..:     |:::|..|
Zfish   203 RRDELK---HNQRLN---LEDLLSHSWLPQD-----RFSESPDT 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvf1	NP_523407.1	PDGF	142..223	CDD:278756	21/85 (25%)
pdgfbb	XP_005171668.1	PDGF	86..169	CDD:306779	21/85 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582433
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2C4GD
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1364454at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11633
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1138
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.810