DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvf1 and Pdgfb

DIOPT Version :9

Sequence 1:	NP_523407.1	Gene:	Pvf1 / 32876	FlyBaseID:	FBgn0030964	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	NP_035187.2	Gene:	Pdgfb / 18591	MGIID:	97528	Length:	241	Species:	Mus musculus

Alignment Length:	216	Identity:	50/216 - (23%)
Similarity:	87/216 - (40%)	Gaps:	49/216 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LILPVLLLVLIVSEAAAGSLVSPNNRQPSQRFFYAAATSSSSTQTKVRLLRQADDPSAAPGALEG 81
            |.||:...:.:||  |.|        .|.....|...:..|        :|..||       |:.
Mouse     7 LFLPLCCYLRLVS--AEG--------DPIPEELYEMLSDHS--------IRSFDD-------LQR 46

  Fly    82 SCCQGAAAEAGTPLTLPLSVSAELTNVTADYDVSGEMPSSKENFKRSIMKSTVRNATP---ASCS 143
            ...:.:..|.|..|.|         |:|..:  ||....|....:||:  .::..|.|   |.|.
Mouse    47 LLHRDSVDEDGAELDL---------NMTRAH--SGVELESSSRGRRSL--GSLAAAEPAVIAECK 98

  Fly   144 PQPTIVELKPPAED--EANYYYMPACTRISRCNGCCGSTLISCQPTEVEQVQLRVRKVDRAATSG 206
            .:..:.::.....|  .||:...|.|..:.||:|||.:..:.|:.::|:...::|||::...
Mouse    99 TRTEVFQISRNLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVR--- 160

  Fly   207 RRPF---TIITVEQHTQCRCD 224
            ::|.   ..:|:|.|..|:|:
Mouse   161 KKPIFKKATVTLEDHLACKCE 181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvf1	NP_523407.1	PDGF	142..223	CDD:278756	21/85 (25%)
Pdgfb	NP_035187.2	PDGF_N	21..93	CDD:368059	21/107 (20%)
		PDGF	97..180	CDD:366040	21/85 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..241
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838636
Domainoid	1	1.000	57	1.000	Domainoid score	I10843
eggNOG	1	0.900	-	-		E1_2C4GD
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11633
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1138
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.800