DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7101 and Zfp423

DIOPT Version :9

Sequence 1:	NP_573329.2	Gene:	CG7101 / 32875	FlyBaseID:	FBgn0030963	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_001380647.1	Gene:	Zfp423 / 94188	RGDID:	621664	Length:	1292	Species:	Rattus norvegicus

Alignment Length:	476	Identity:	107/476 - (22%)
Similarity:	162/476 - (34%)	Gaps:	149/476 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PKAPGASNRGALPLAAKKPAK-------------KRTYHCGVC-------FAEFSRHLA---AKR 49
            |.:..:..||:.|.:..||.:             |..|.|..|       .|....||.   |.:
  Rat   380 PDSSASVERGSTPDSTLKPLRGQKKMRDDGQSWSKVVYSCPYCSKRDFTSLAVLEIHLKTIHADK 444

  Fly    50 HEQQ--CSV-------------RVRRL----------------FVCPHCLTLFGEEARLERHRER 83
            .:|.  |.:             .||:|                |.|.:|..:|.:...|:.|...
  Rat   445 PQQSHTCQICLDSMPTLYNLNEHVRKLHKSHAYPVMQFGNISAFHCNYCPEMFADINSLQEHIRV 509

  Fly    84 KH-------NDGQ--FLCLQCGKKYASATFLYRHVASWH---GQQSL--------------FYCD 122
            .|       .||.  |.|.||...:.:.:.|..|:...|   |...|              :.|.
  Rat   510 SHCGPNANPPDGNNAFFCNQCSMGFLTESSLTEHIQQAHCSVGSTKLESPVIQPTQSFMEVYSCP 574

  Fly   123 MCTDNCNDVKTFSGMLELQEHAEEVHRLRTLKSTASDADSQVDEMEDLEM---LEENIENILPSI 184
            .||::    ..|..:|:|.:|.:|.|:...|..:......|.....|:|:   ..:.:.....||
  Rat   575 YCTNS----PIFGSILKLTKHIKENHKNIPLAHSKKSKAEQSPVSSDVEVSSPKRQRLSGSANSI 635

  Fly   185 DWDD------DLTF----GWPTDLDKESCIVNAKPSVFVCPFCANGFPGSLSLVRHLEQVHERSA 239
            ...:      ||.|    .:.|.|.....::..|.:   ||.|...|....||::|| .||..:.
  Rat   636 SNGEYPCNQCDLKFSNFESFQTHLKLHLELLLRKQA---CPQCKEDFDSQESLLQHL-TVHYMTT 696

  Fly   240 LD---CCYCGKSHGSREALRSHLQRVHILLRGHVCGICQA------------------------- 276
            ..   |..|.|...|.:.|:.||..:|..:..| |.:||.
  Rat   697 STHYVCESCDKQFSSVDDLQKHLLDMHTFVLYH-CTLCQEVFDSKVSIQVHLAVKHSNEKKMYRC 760

  Fly   277 -----DFATADHLKKHVNSLHLDH--RPHLCPTCGKRFTQ----RCHLTDHIKTDRGHGHGTYTC 330
                 ||.....|:.||...||.:  :.|.|..||:.|:.    :||:|.|.|        .|.|
  Rat   761 TACNWDFRKEADLQVHVKHSHLGNPAKAHKCIFCGETFSTEVELQCHITTHSK--------KYNC 817

  Fly   331 EFCVRPFFRAIDLERHVCEEH 351
            .||.:.|...:.||:|:.|:|
  Rat   818 RFCSKAFHAVLLLEKHLREKH 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7101	NP_573329.2	PHA00733	<210..263	CDD:177301	17/55 (31%)
		C2H2 Zn finger	242..263	CDD:275368	7/20 (35%)
		C2H2 Zn finger	271..292	CDD:275368	8/50 (16%)
		C2H2 Zn finger	300..319	CDD:275368	8/22 (36%)
		C2H2 Zn finger	330..347	CDD:275368	6/16 (38%)
Zfp423	NP_001380647.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..70
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..123
		C2H2 Zn finger	148..168	CDD:275368
		C2H2 Zn finger	176..196	CDD:275368
		COG5048	202..603	CDD:227381	47/226 (21%)
		C2H2 Zn finger	204..224	CDD:275368
		C2H2 Zn finger	232..252	CDD:275368
		C2H2 Zn finger	273..292	CDD:275368
		C2H2 Zn finger	419..440	CDD:275368	5/20 (25%)
		C2H2 Zn finger	451..475	CDD:275368	4/23 (17%)
		C2H2 Zn finger	490..509	CDD:275368	5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..635		4/36 (11%)
		C2H2 Zn finger	672..692	CDD:275368	8/20 (40%)
		C2H2 Zn finger	702..723	CDD:275368	7/20 (35%)
		C2H2 Zn finger	730..751	CDD:275368	3/20 (15%)
		C2H2 Zn finger	760..781	CDD:275368	5/20 (25%)
		C2H2 Zn finger	791..811	CDD:275368	7/19 (37%)
		C2H2 Zn finger	817..835	CDD:275368	7/17 (41%)
		C2H2 Zn finger	896..917	CDD:275368
		C2H2 Zn finger	940..960	CDD:275368
		C2H2 Zn finger	969..989	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1144..1171
		C2H2 Zn finger	1208..1228	CDD:275368
		C2H2 Zn finger	1239..1260	CDD:275368
		C2H2 Zn finger	1269..1285	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002621
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000