DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7101 and ZNF347

DIOPT Version :9

Sequence 1:	NP_573329.2	Gene:	CG7101 / 32875	FlyBaseID:	FBgn0030963	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_001166145.1	Gene:	ZNF347 / 84671	HGNCID:	16447	Length:	840	Species:	Homo sapiens

Alignment Length:	350	Identity:	82/350 - (23%)
Similarity:	127/350 - (36%)	Gaps:	80/350 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KRTYHCGVCFAEFSRHLAAKRHEQQCSVRV-RRLFVCPHCLTLFGEEARLERHRERKHNDGQFLC 92
            ::.|.|..|...|||:....:|::   :.. .:.:.|..|..:|.:.:.|.|||.....:..:.|
Human   315 EKRYKCNECGKVFSRNSQLSQHQK---IHTGEKPYKCNECGKVFTQNSHLVRHRGIHTGEKPYKC 376

  Fly    93 LQCGKKYASATFLYRHVASWHGQQSLFYCDMC----TDN-----------------CNDV-KTFS 135
            .:|||.:.:.:.|..|.|: |..:..:.|:.|    |.|                 ||:. |.|.
Human   377 NECGKAFRARSSLAIHQAT-HSGEKPYKCNECGKVFTQNSHLTNHWRIHTGEKPYKCNECGKAFG 440

  Fly   136 GMLELQEH-----AEEVHRLRTLKSTASDADSQVDEMEDLEMLEENIENILPSIDWDDDLTFGWP 195
            ....|..|     .|:.::..                |..::...|
Human   441 VRSSLAIHLVIHTGEKPYKCH----------------ECGKVFRRN------------------- 470

  Fly   196 TDLDKESCI-VNAKPSVFVCPFCANGFPGSLSLVRHLEQVHE-RSALDCCYCGKSHGSREALRSH 258
            :.|.:...| ...||  :.|..|...|....:|..| :.:|. .....|..|||.......|.:|
Human   471 SHLARHQLIHTGEKP--YKCNECGKAFRAHSNLTTH-QVIHTGEKPYKCNECGKVFTQNSHLANH 532

  Fly   259 LQRVHILLRGHVCGICQADFATADHLKKHVNSLHLDHRPHLCPTCGKRFTQRCHLTDHIKTDRG- 322
             ||:|..::.::|..|...|:....|..| ..:|...:|:.|..|||.|||..||..|    ||
Human   533 -QRIHTGVKPYMCNECGKAFSVYSSLTTH-QVIHTGEKPYKCNECGKVFTQNSHLARH----RGI 591

  Fly   323 H-GHGTYTCEFCVRPFFRAIDLERH 346
            | |...|.|..|.:.|.....|.||
Human   592 HTGEKPYKCNECGKVFRHNSYLSRH 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7101	NP_573329.2	PHA00733	<210..263	CDD:177301	14/53 (26%)
		C2H2 Zn finger	242..263	CDD:275368	8/20 (40%)
		C2H2 Zn finger	271..292	CDD:275368	5/20 (25%)
		C2H2 Zn finger	300..319	CDD:275368	10/18 (56%)
		C2H2 Zn finger	330..347	CDD:275368	5/16 (31%)
ZNF347	NP_001166145.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	265..284	CDD:275368
		COG5048	273..728	CDD:227381	81/349 (23%)
		zf-H2C2_2	276..301	CDD:290200
		C2H2 Zn finger	292..312	CDD:275368
		zf-H2C2_2	304..329	CDD:290200	4/13 (31%)
		C2H2 Zn finger	320..340	CDD:275368	6/22 (27%)
		zf-H2C2_2	333..357	CDD:290200	4/26 (15%)
		C2H2 Zn finger	348..368	CDD:275368	7/19 (37%)
		zf-H2C2_2	360..383	CDD:290200	8/22 (36%)
		C2H2 Zn finger	376..396	CDD:275368	7/20 (35%)
		zf-H2C2_2	388..413	CDD:290200	6/25 (24%)
		C2H2 Zn finger	404..424	CDD:275368	4/19 (21%)
		zf-H2C2_2	416..439	CDD:290200	3/22 (14%)
		C2H2 Zn finger	432..452	CDD:275368	6/19 (32%)
		zf-H2C2_2	444..469	CDD:290200	4/40 (10%)
		zf-C2H2	458..480	CDD:278523	3/56 (5%)
		C2H2 Zn finger	460..480	CDD:275368	3/54 (6%)
		zf-H2C2_2	472..495	CDD:290200	6/24 (25%)
		C2H2 Zn finger	488..508	CDD:275368	5/20 (25%)
		zf-H2C2_2	500..525	CDD:290200	7/25 (28%)
		C2H2 Zn finger	516..536	CDD:275368	8/20 (40%)
		zf-H2C2_2	528..552	CDD:290200	7/24 (29%)
		C2H2 Zn finger	544..564	CDD:275368	5/20 (25%)
		zf-H2C2_2	556..581	CDD:290200	9/25 (36%)
		C2H2 Zn finger	572..592	CDD:275368	12/23 (52%)
		zf-H2C2_2	584..609	CDD:290200	11/28 (39%)
		C2H2 Zn finger	600..620	CDD:275368	5/16 (31%)
		C2H2 Zn finger	628..648	CDD:275368
		zf-H2C2_2	640..665	CDD:290200
		C2H2 Zn finger	656..676	CDD:275368
		zf-H2C2_2	668..693	CDD:290200
		C2H2 Zn finger	684..704	CDD:275368
		zf-H2C2_2	697..720	CDD:290200
		C2H2 Zn finger	712..732	CDD:275368
		COG5048	723..>817	CDD:227381
		zf-H2C2_2	724..749	CDD:290200
		C2H2 Zn finger	740..760	CDD:275368
		zf-H2C2_2	752..777	CDD:290200
		C2H2 Zn finger	768..788	CDD:275368
		C2H2 Zn finger	795..813	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142390
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930