DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7101 and ZNF208

DIOPT Version :9

Sequence 1:	NP_573329.2	Gene:	CG7101 / 32875	FlyBaseID:	FBgn0030963	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_009084.2	Gene:	ZNF208 / 7757	HGNCID:	12999	Length:	1280	Species:	Homo sapiens

Alignment Length:	369	Identity:	77/369 - (20%)
Similarity:	134/369 - (36%)	Gaps:	72/369 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KRTYHCGVCFAEFSRHLAAKRHE-----------QQCSV---------------RVRRLFVCPHC 67
            ::.|.|..|...||......:|:           ::|..               .|.:.:.|..|
Human   522 EKPYKCEECGKSFSTFSILTKHKVIHTGEKPYKCEECGKAYKWSSTLSYHKKIHTVEKPYKCEEC 586

  Fly    68 LTLFGEEARLERHRERKHNDGQFLCLQCGKKYASATFLYRHVASWHGQQSLFYCDMCTDNCNDVK 132
            ...|.:.|.|.:|:.....:..:.|.:|||.::..:.|..|.|. |..:..:.|..|.      |
Human   587 GKAFNQSAILIKHKRIHTGEKPYKCEECGKTFSKVSTLTTHKAI-HAGEKPYKCKECG------K 644

  Fly   133 TFSGMLELQEH-----AEEVHRLRTLKSTASDADSQVDEMEDLEMLEE-----NIENILPSIDWD 187
            ||..:..|..|     .|:.::.:    ....|.|:...:...:::..     ..|....:.:|.
Human   645 TFIKVSTLTTHKAIHAGEKPYKCK----ECGKAFSKFSILTKHKVIHTGEKPYKCEECGKAFNWS 705

  Fly   188 DDLTFGWPTDLDKESCIVNAKPSVFVCPFCANGFPGSLSLVRHLEQVHE-RSALDCCYCGKSHGS 251
            .:|       ::.:......||  :.|..|...|.....|.:| :.:|. .....|..|||::..
Human   706 SNL-------MEHKRIHTGEKP--YKCEECGKSFSTFSVLTKH-KVIHTGEKPYKCEECGKAYKW 760

  Fly   252 REALRSHLQRVHILLRGHVCGICQADFATADHLKKHVNSLHLDHRPHLCPTCGKRFTQRCHLTDH 316
            ...|..| :::|.:.:.:.|..|...|..:..|.|| ..:|.|.:|:.|..|||.|::...||.|
Human   761 SSTLSYH-KKIHTVEKPYKCEECGKAFNRSAILIKH-KRIHTDEKPYKCEECGKTFSKVSTLTTH 823

  Fly   317 IKTDRGHGHGTYTCEFCVRPFFRAIDLERH----------VCEE 350
            .....  |...|.|:.|.:.|.:...|.:|          .|||
Human   824 KAIHA--GEKPYKCKECGKAFSKFSILTKHKVIHTGEKPYKCEE 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7101	NP_573329.2	PHA00733	<210..263	CDD:177301	12/53 (23%)
		C2H2 Zn finger	242..263	CDD:275368	6/20 (30%)
		C2H2 Zn finger	271..292	CDD:275368	6/20 (30%)
		C2H2 Zn finger	300..319	CDD:275368	8/18 (44%)
		C2H2 Zn finger	330..347	CDD:275368	5/26 (19%)
ZNF208	NP_009084.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		COG5048	227..619	CDD:227381	18/96 (19%)
		C2H2 Zn finger	231..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		C2H2 Zn finger	287..307	CDD:275368
		C2H2 Zn finger	315..335	CDD:275368
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		zf-H2C2_2	384..407	CDD:290200
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368
		zf-H2C2_2	439..463	CDD:290200
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	499..519	CDD:275368
		zf-H2C2_2	511..536	CDD:290200	4/13 (31%)
		C2H2 Zn finger	527..547	CDD:275368	5/19 (26%)
		C2H2 Zn finger	555..575	CDD:275368	1/19 (5%)
		zf-H2C2_2	568..592	CDD:290200	4/23 (17%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..619	CDD:290200	6/22 (27%)
		C2H2 Zn finger	611..631	CDD:275368	7/20 (35%)
		C2H2 Zn finger	639..659	CDD:275368	7/25 (28%)
		C2H2 Zn finger	667..687	CDD:275368	2/23 (9%)
		COG5048	691..1133	CDD:227381	45/189 (24%)
		C2H2 Zn finger	695..715	CDD:275368	3/26 (12%)
		zf-H2C2_2	707..732	CDD:290200	6/33 (18%)
		C2H2 Zn finger	723..743	CDD:275368	5/20 (25%)
		C2H2 Zn finger	751..771	CDD:275368	6/20 (30%)
		zf-H2C2_2	764..788	CDD:290200	6/24 (25%)
		C2H2 Zn finger	779..799	CDD:275368	6/20 (30%)
		C2H2 Zn finger	807..827	CDD:275368	8/19 (42%)
		C2H2 Zn finger	835..855	CDD:275368	5/19 (26%)
		C2H2 Zn finger	863..883	CDD:275368	3/3 (100%)
		zf-H2C2_2	876..899	CDD:290200
		C2H2 Zn finger	891..911	CDD:275368
		C2H2 Zn finger	919..939	CDD:275368
		C2H2 Zn finger	947..967	CDD:275368
		C2H2 Zn finger	976..995	CDD:275368
		C2H2 Zn finger	1003..1023	CDD:275368
		zf-H2C2_2	1015..1039	CDD:290200
		C2H2 Zn finger	1031..1051	CDD:275368
		C2H2 Zn finger	1059..1079	CDD:275368
		C2H2 Zn finger	1087..1107	CDD:275368
		zf-H2C2_2	1099..1124	CDD:290200
		C2H2 Zn finger	1115..1135	CDD:275368
		C2H2 Zn finger	1143..1163	CDD:275368
		C2H2 Zn finger	1171..1191	CDD:275368
		C2H2 Zn finger	1199..1219	CDD:275368
		zf-H2C2_2	1212..1236	CDD:290200
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1255..1275	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142377
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930