DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7101 and ZNF729

DIOPT Version :9

Sequence 1:	NP_573329.2	Gene:	CG7101 / 32875	FlyBaseID:	FBgn0030963	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_001229609.1	Gene:	ZNF729 / 100287226	HGNCID:	32464	Length:	1252	Species:	Homo sapiens

Alignment Length:	358	Identity:	81/358 - (22%)
Similarity:	132/358 - (36%)	Gaps:	89/358 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AKKPAKKRTYHCGVCFAEFSRHLAAKRHE-----------QQCSVRV---------------RRL 61
            |:||.|  ...||..|..||   |.::|:           ::|....               ::.
Human   904 AEKPCK--CEECGKAFKHFS---ALRKHKIIHTGKKPYKCEECGKAFNDSSTLMKHKIIHTGKKP 963

  Fly    62 FVCPHCLTLFGEEARLERHRERKHNDGQFLCLQCGKKYASATFLYRHVASWHGQQSLFYCDMCTD 126
            :.|..|...|.:.:.|.||:.....:..:.|.:|||.:.:::.|.:|... |.::.|:.|:.|
Human   964 YKCAECGKAFKQSSHLTRHKAIHTGEKPYKCEECGKDFNNSSTLKKHKLI-HTREKLYKCEEC-- 1025

  Fly   127 NCNDVKTFSGMLELQEH-----AEEVHRLRTLKSTASDADSQVDEMEDLEMLEENIENILPSIDW 186
                ||.|:....|.:|     .|:.::                           .|....:..|
Human  1026 ----VKAFNNFSALMKHKIIHTGEKPYK---------------------------CEECGKAFKW 1059

  Fly   187 DDDLTFGWPTDLDKESCIVNAKPSVFVCPFCANGFPGSLSLVRHLEQVHE-RSALDCCYCGKSHG 250
            ...||         |..:::.......|..|...|....:|.:| :.:|. :....|..|||:..
Human  1060 SSKLT---------EHKVIHTGEKPCKCEECDKAFKHFSALRKH-KVIHTGKKPYQCDECGKAFN 1114

  Fly   251 SREALRSHLQRVHILLRGHVCGICQADFATADHLKKHVNSLHLDHRPHLCPTCGKRFTQRCHLTD 315
            :...|..| :.:|...:.:.|..|...|:.:..|.|| ..:|...:|:.|..|||.|.|..|||.
Human  1115 NSSTLTKH-KIIHTGEKPYKCEECGKAFSQSSILTKH-KIIHSVEKPYKCEECGKAFNQSSHLTR 1177

  Fly   316 H--IKTDRGHGHGTYTCEFCVRPFFRAIDLERH 346
            |  |.|    |...|.||.|.:.|.:...|.||
Human  1178 HKTIHT----GEKPYKCEECGKAFIQCSYLIRH 1206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7101	NP_573329.2	PHA00733	<210..263	CDD:177301	12/53 (23%)
		C2H2 Zn finger	242..263	CDD:275368	6/20 (30%)
		C2H2 Zn finger	271..292	CDD:275368	6/20 (30%)
		C2H2 Zn finger	300..319	CDD:275368	11/20 (55%)
		C2H2 Zn finger	330..347	CDD:275368	7/17 (41%)
ZNF729	NP_001229609.1	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	182..202	CDD:275368
		C2H2 Zn finger	210..230	CDD:275368
		C2H2 Zn finger	239..258	CDD:275368
		COG5048	262..666	CDD:227381
		C2H2 Zn finger	266..286	CDD:275368
		C2H2 Zn finger	294..314	CDD:275368
		C2H2 Zn finger	322..342	CDD:275368
		C2H2 Zn finger	351..370	CDD:275368
		zf-H2C2_2	363..386	CDD:290200
		C2H2 Zn finger	378..398	CDD:275368
		C2H2 Zn finger	406..426	CDD:275368
		C2H2 Zn finger	434..454	CDD:275368
		C2H2 Zn finger	462..482	CDD:275368
		zf-H2C2_2	474..499	CDD:290200
		C2H2 Zn finger	490..510	CDD:275368
		zf-H2C2_2	502..527	CDD:290200
		C2H2 Zn finger	518..538	CDD:275368
		zf-H2C2_2	531..554	CDD:290200
		C2H2 Zn finger	546..566	CDD:275368
		C2H2 Zn finger	574..594	CDD:275368
		C2H2 Zn finger	602..622	CDD:275368
		COG5048	625..1123	CDD:227381	51/268 (19%)
		C2H2 Zn finger	630..650	CDD:275368
		zf-H2C2_2	642..667	CDD:290200
		C2H2 Zn finger	658..678	CDD:275368
		zf-H2C2_2	670..695	CDD:290200
		C2H2 Zn finger	686..706	CDD:275368
		zf-H2C2_2	698..722	CDD:290200
		C2H2 Zn finger	714..734	CDD:275368
		C2H2 Zn finger	742..762	CDD:275368
		C2H2 Zn finger	770..790	CDD:275368
		C2H2 Zn finger	798..818	CDD:275368
		C2H2 Zn finger	826..846	CDD:275368
		C2H2 Zn finger	854..874	CDD:275368
		zf-H2C2_2	866..890	CDD:290200
		C2H2 Zn finger	882..902	CDD:275368
		C2H2 Zn finger	910..930	CDD:275368	7/22 (32%)
		C2H2 Zn finger	938..958	CDD:275368	1/19 (5%)
		C2H2 Zn finger	966..986	CDD:275368	6/19 (32%)
		zf-H2C2_2	978..1003	CDD:290200	7/24 (29%)
		C2H2 Zn finger	994..1014	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1022..1042	CDD:275368	7/25 (28%)
		zf-H2C2_2	1034..1058	CDD:290200	4/50 (8%)
		C2H2 Zn finger	1050..1070	CDD:275368	5/28 (18%)
		C2H2 Zn finger	1078..1098	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1106..1126	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1134..1154	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1162..1182	CDD:275368	10/19 (53%)
		C2H2 Zn finger	1190..1210	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142240
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930