Protein Alignment CG42450 and RGS6

DIOPT Version :10

• Sequence 1: NP_001259691.1
• Gene: CG42450 / 32874
• FlyBaseID: FBgn0259927
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: XP_024305527.1
• Gene: RGS6 / 9628
• HGNCID: 10002
• Length: 684
• Species: Homo sapiens
• Alignment Length: 725
• Identity: 249/725 - (34%)
• Similarity: 367/725 - (50%)
• Gaps: 137/725 - (18%)

  Fly   197 GSGNQQQ---AIEKLSRP--MAFDKMEMLVREMQDQE-HGVPVRQQKMFLTSIPYAFMGYDLIEW 255
            |||:|:.   |..:.|.|  :.:.|:|.::.:|||.: .|||:|..|.||:.||....|.|:::|
Human     4 GSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQW 68

  Fly   256 LMDRLQIEES-EALNIANQLCLHGYFFPVNDSKTLTVKDDSSLYRFQTPYYWP---WQHKAPDNV 316
            ||..|.||:. ||:::.:.:...||.||::| ..||:|||.:.||||.||:||   |:   |:|.
Human    69 LMKNLSIEDPVEAIHLGSLIAAQGYIFPISD-HVLTMKDDGTFYRFQAPYFWPSNCWE---PENT 129

  Fly   317 EYAIYLAKRSLRNKQRHALEDYEAEALASLHKNLKGKWDFISMQAEEQVRLAKERKKGDKIVGDS 381
            :|||||.||:::||.|..|.|||||.||.|.:....||:||.||||.||::.:::.|.::.:.||
Human   130 DYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDS 194

  Fly   382 QERAYWRVHRPPPGQFTPLE----PC---PVPSRDRQGL-----------------KPNKKKTVD 422
            ||||:|.||||.||.....|    .|   ..|.:.::.:                 :|.:|.|.:
Human   195 QERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKE 259

  Fly   423 DMQRDVDYLGKSLNRTRMKMSQACESLVCYSETFSEYDFFLQPALPSNPWVTEDIAFWQLNNTFV 487
            |:::.:.:|...::|..:|||:..|||:.|:|.:.|||..:.||.|||||:::|:|.|.:..:
Human   260 DIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMS-- 322

  Fly   488 DIPTEKRVKRWAISIEELVSDPTGLQEFTGFLEKEYSHENIRFWIAVNRLRRSAHSQVARKVNEI 552
            ..|:::|||||..|.:|::.|..|..:|..|||.|:|.||:|||:||..|::.....||::|.||
Human   323 KEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEI 387

  Fly   553 YEEFLKPGAPCEINIDGKTMESVLKGLKNPSRFTFDSASEHIYMLLLKKDCYPRFIRSEHYKRLL 617
            ::|||.||||..||:|..:.|...:.:|:..|:||:.|.||||. |:|.|.|.||:||..|:.||
Human   388 WQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYK-LMKSDSYARFLRSNAYQDLL 451

  Fly   618 --------DTGIQPSYKK--RFFNFGGV--SGAKKKMTAALS--------------------SQP 650
                    :.|.:.|.:|  |..|....  :||.....|||.                    ..|
Human   452 LAKKKPESEQGRRTSLEKFTRSVNVQNTRPAGAWSIFMAALPMAVWLRTPRSCHGLSESRLLGLP 516

  Fly   651 NL-----------GDAAKGPSGT-----SAGSSMMQAPPPGNLARRRGSDR-SLTGSAHELAVIG 698
            :|           |.|..||...     :||.....|.|.|...|...:|| ||.|   :|..:
Human   517 SLHDGLREGKVAGGQAPHGPDAVLLTVPTAGPGPGPADPTGRRRRSTSADRVSLRG---DLVTV- 577

  Fly   699 VNKDAGSKVPHSHSQSNLSEIPFSSDSIYRGDMPQRHMAIMDIGIYAAYGNRESSLQALPE---- 759
            ..||.   :|..||      :.....|.:||:    |:    :|..:........|.:||.
Human   578 KEKDC---IPTLHS------LRGPDPSSFRGE----HV----VGFLSRLSLEIILLSSLPRCLET 625

  Fly   760 -TPKTKTTVLDATESTSS--STALAAAASSAVCPWDDPAESVPPPPPPAQVKLSVCPWELDSATE 821
             ||..|....:.||||||  .|:||....:|          ...||||....:||.
Human   626 VTPSGKFKRHEWTESTSSICITSLAPPIVTA----------TTSPPPPVIPHVSVA--------- 671

  Fly   822 TPTAAPAVGS 831
            |..:.||.|:
Human   672 TRVSLPAPGT 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42450	NP_001259691.1	DEP_RGS7-like	219..306	CDD:239897	38/88 (43%)
		RGS_DHEX	303..401	CDD:375589	50/100 (50%)
		G-gamma	418..482	CDD:459879	26/63 (41%)
		RGS_R7-like	494..614	CDD:188660	56/119 (47%)
RGS6	XP_024305527.1	DEP_RGS7-like	31..119	CDD:239897	38/88 (43%)
		RGS_DHEX	116..217	CDD:375589	51/103 (50%)
		GGL	258..319	CDD:128520	24/60 (40%)
		RGS_RGS6	328..452	CDD:188691	58/124 (47%)