Protein Alignment CG42450 and AXIN2

DIOPT Version :10

• Sequence 1: NP_001259691.1
• Gene: CG42450 / 32874
• FlyBaseID: FBgn0259927
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: NP_004646.3
• Gene: AXIN2 / 8313
• HGNCID: 904
• Length: 843
• Species: Homo sapiens
• Alignment Length: 1020
• Identity: 195/1020 - (19%)
• Similarity: 309/1020 - (30%)
• Gaps: 362/1020 - (35%)

  Fly   391 RPP-PGQFTPLEPCPVPSRDRQGLKPNKKKTVDDMQRDVDYLGKSLNRTRMKMSQACESLVCYSE 454
            ||| ||:.....||.......|..||  .....:.:|:.|.||:...|
Human    23 RPPVPGEEGETPPCQPGVGKGQVTKP--MPVSSNTRRNEDGLGEPEGR----------------- 68

  Fly   455 TFSEYDFFLQPALPSNPWVTEDIAFWQLNNTFVDIPTEKRVKRWAISIEELVSDPTGLQEFTGFL 519
                       |.|.:|                       :.||..|:..|:.|..|...|..||
Human    69 -----------ASPDSP-----------------------LTRWTKSLHSLLGDQDGAYLFRTFL 99

  Fly   520 EKEYSHENIRFWIAVNRLRRS--AHSQVARKVNEIYEEFLKPGAPCEINIDGKTMESVLKGLKNP 582
            |:|...:.:.||.|.|..|:.  ..::..|....||:.:::..:.....:...|...:..|:|..
Human   100 EREKCVDTLDFWFACNGFRQMNLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQ 164

  Fly   583 --SRFTFDSA--------SEHIYMLLLKKDCYPRFIRSEHYKRLLDTGIQPSYKKRFFNFGGVSG 637
              ....||.|        .|:.|.:.|..|.|..::||        .|...:|...    ||: |
Human   165 QIDSIMFDQAQTEIQSVMEENAYQMFLTSDIYLEYVRS--------GGENTAYMSN----GGL-G 216

  Fly   638 AKKKMTAALSSQPNLGDAAKGPSGTSAGSSMMQAPPPGNLARRRGSDRSLTGSAHELAVIGVNKD 702
            :.|.:...|   |.|.:..:   .|.|......:|....|     |.::|..:|...:...|  |
Human   217 SLKVVCGYL---PTLNEEEE---WTCADFKCKLSPTVVGL-----SSKTLRATASVRSTETV--D 268

  Fly   703 AGSK-------VPHSH----------SQSNLSEIPFSSDSIYRGDMPQRHMAIMDIGIY------ 744
            :|.:       |...|          :.:|.|||  |||::....|.....::..|..|
Human   269 SGYRSFKRSDPVNPYHIGSGYVFAPATSANDSEI--SSDALTDDSMSMTDSSVDGIPPYRVGSKK 331

  Fly   745 --------AAYGNRESSLQALPET---PKTKTTVLDATESTSSSTALAAAASSAVCPWDDPAESV 798
                    :...|.:.||...|.|   ||..|.|..||        .||...|.:
Human   332 QLQREMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPAT--------FAAELISRL---------- 378

  Fly   799 PPPPPPAQVKLSVCPWELDSATETPTAAPAVGSGGGGAGASKILSS-----TGQPMRLNSTSSDN 858
                  .::||     ||:|..........:.......|:...|:|     |..|:.|..:.|..
Human   379 ------EKLKL-----ELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQHPLSLLPSGSYE 432

  Fly   859 SD----VNDRMQRNLGIRHQNTVDSGEAGIKRLIPNIPEQRRASVSFTPSPTPDFQL-------- 911
            .|    ::|.:.|.|     .|......|:.|..|.             |.:||...
Human   433 EDPQTILDDHLSRVL-----KTPGCQSPGVGRYSPR-------------SRSPDHHHHHHSQYHS 479

  Fly   912 -----GRTPTTTSSPTVAPSSSTPLQARSAVYGSGQGIAKD---------------PPSGSDVDA 956
                 |:.|...:||...|           :.|....:.|.               |.:..:::|
Human   480 LLPPGGKLPPAAASPGACP-----------LLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEA 533

  Fly   957 ELEEELNKISLGESSISEPPLLVVPTPEQTPPPITKITPPPGESE----------NQADQVIDST 1011
            |..:.::...                              ||.||          ::|.:.:.|.
Human   534 EATQRVHCFC------------------------------PGGSEYYCYSKCKSHSKAPETMPSE 568

  Fly  1012 EIPGSSCSTQANQFGEATATVTTVKEVQIELIEQVSGV----------QTEPDSPPTIKVLVLEA 1066
            :..||..||...:.|:.|       |..:.|..:..|.          :.|.|....:...:||:
Human   569 QFGGSRGSTLPKRNGKGT-------EPGLALPAREGGAPGGAGALQLPREEGDRSQDVWQWMLES 626

  Fly  1067 -----TTPVSA---------ETATADPGENLAK------MATASNTTT---ITTDDQAM------ 1102
                 ..|.||         |:|.:.|||..::      .:....||.   :.|.|.||
Human   627 ERQSKPKPHSAQSTKKAYPLESARSSPGERASRHHLWGGNSGHPRTTPRAHLFTQDPAMPPLTPP 691

  Fly  1103 ----RADDDAERAAEIEQTVLDELSPTTDEYQEFGDAKDAVDDFDSIDIGYIPPAPTPAPSMAPL 1163
                :.::...|.||:.:.........:.:......|        ::..|   ..|...||:||
Human   692 NTLAQLEEACRRLAEVSKPPKQRCCVASQQRDRNHSA--------TVQTG---ATPFSNPSLAP- 744

  Fly  1164 AELDVDTVDDEPCEPAAPPPSHSAPASSSSRELVMASGSVTATPTSSNEEARKRRKKRNSE---- 1224
                     ::..||......|:..||    |||:       |.....||...||..:...
Human   745 ---------EDHKEPKKLAGVHALQAS----ELVV-------TYFFCGEEIPYRRMLKAQSLTLG 789

  Fly  1225 --GKKLSSQDDK----DKDAHERAGGSSMDAADHNAVCPWEDENV 1263
              .::||.:.:.    .|.:.|.|.|:..:..       ||||.|
Human   790 HFKEQLSKKGNYRYYFKKASDEFACGAVFEEI-------WEDETV 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42450	NP_001259691.1	DEP_RGS7-like	219..306	CDD:239897
		RGS_DHEX	303..401	CDD:375589	5/10 (50%)
		G-gamma	418..482	CDD:459879	8/63 (13%)
		RGS_R7-like	494..614	CDD:188660	32/131 (24%)
AXIN2	NP_004646.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..75		18/104 (17%)
		AXIN1_TNKS_BD	10..75	CDD:465215	18/104 (17%)
		Tankyrase-binding motif	21..30		5/6 (83%)
		RGS_Axin	82..198	CDD:188662	27/115 (23%)
		Interaction with GSK3B. /evidence=ECO:0000250	327..413		21/114 (18%)
		Interaction with SIAH1 and SIAH2. /evidence=ECO:0000269|PubMed:28546513	334..393		19/87 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	396..435		7/38 (18%)
		Interaction with beta-catenin. /evidence=ECO:0000250	413..476		16/80 (20%)
		Axin_b-cat_bind	433..468	CDD:462616	9/52 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	447..494		10/64 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	561..674		24/119 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	718..748		7/50 (14%)
		DAX	761..843	CDD:197474	21/85 (25%)