Protein Alignment CG42450 and AXIN1

DIOPT Version :10

• Sequence 1: NP_001259691.1
• Gene: CG42450 / 32874
• FlyBaseID: FBgn0259927
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: XP_011520984.1
• Gene: AXIN1 / 8312
• HGNCID: 903
• Length: 916
• Species: Homo sapiens
• Alignment Length: 928
• Identity: 173/928 - (18%)
• Similarity: 257/928 - (27%)
• Gaps: 380/928 - (40%)

  Fly   457 SEYDFFLQP---ALPSNPWVTEDIAFWQLNNTFVDIPTEKRVKRWAISIEELVSDPTGLQEFTGF 518
            |:.|...:|   |.|:.|::                       :||.|:..|:.|..|:..|..|
Human   113 SDLDLGYEPEGSASPTPPYL-----------------------KWAESLHSLLDDQDGISLFRTF 154

  Fly   519 LEKEYSHENIRFWIAVNRLRR-----SAHSQVARKVNEIYEEFL-----------KPGAPCEINI 567
            |::|...:.:.||.|....|:     |...:..:....||.:::           ||.....|.
Human   155 LKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIK- 218

  Fly   568 DGKTMESVLKGLKNPSRFTFDSASEHIYMLLLKKDCYPRFIRSEHYKRLLDTGIQPSYKKRFFNF 632
                 ..::|.|.:|:  .||.|...| ...::::.||.|::|:.|.....||
Human   219 -----GCIMKQLIDPA--MFDQAQTEI-QATMEENTYPSFLKSDIYLEYTRTG------------ 263

  Fly   633 GGVSGAKKKMTAALSSQPNLGDAAKGPSGTSAGSS----------------------MMQAPPPG 675
                          |..|.:.......|||..|.|                      ...|.|||
Human   264 --------------SESPKVCSDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPG 314

  Fly   676 NL---------------ARRRGSDRSLT-GSAHELAVIGVNK---DAGSKVPHSHSQSNLSEIPF 721
            .|               :||....|... ||..|    .||.   :||..:..:.|.::..:...
Human   315 RLPQKLLLETAAPRVSSSRRYSEGREFRYGSWRE----PVNPYYVNAGYALAPATSANDSEQQSL 375

  Fly   722 SS--------DSIYRGDMPQR----HMAIMDIGIYAAYGNRESSLQALPETPKTKT--------- 765
            ||        ||...|..|.|    |...|...:..   |....|..:|..|..:|
Human   376 SSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQV---NGRVPLPHIPSCPSQRTYRVPKEVRV 437

  Fly   766 ----------TVLDATESTSSSTALAAAASSAVCPWDD------------PAESVPPPP-----P 803
                      ..|:|.:.|..:..........|...::            |...:||.|     |
Human   438 EPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEEEGEDGDPSSGPPGPCHKLPPAPAWHHFP 502

  Fly   804 PAQVKLSVCPWELDSATETP-------------------------------TAAPAVGSGGGGAG 837
            |..|.:. |....|:..|.|                               .|...|..||..:|
Human   503 PRCVDMG-CAGLRDAHEENPESILDEHVQRVLRTPGRQSPGPGHRSPDSGHVAKMPVALGGAASG 566

  Fly   838 ASKILSSTGQPMRLNSTSSDNSDVNDRMQRNLGIRH----QNTVDSGEAGIKRLIPNIPEQRRAS 898
            ..|.:..:|  .:|::.               |:.|    .:.|....|..|..: .....|||.
Human   567 HGKHVPKSG--AKLDAA---------------GLHHHRHVHHHVHHSTARPKEQV-EAEATRRAQ 613

  Fly   899 VSFTPSPTPDFQLGRTPTTTSSPTVAPSSSTPLQARSAVYGSGQGIAKDPPSGSDVDAELEEELN 963
            .||.....|.....|:...:.|...||::|             .|:|.   ||. |....:....
Human   614 SSFAWGLEPHSHGARSRGYSESVGAAPNAS-------------DGLAH---SGK-VGVACKRNAK 661

  Fly   964 KISLGESSISEPPLLVVPTPEQTPPPITKITPPPGESENQADQVIDSTEIPGSSCSTQANQFGEA 1028
            |...|:|:                                      |||:||:|...:.||
Human   662 KAESGKSA--------------------------------------STEVPGASEDAEKNQ---- 684

  Fly  1029 TATVTTVKEVQIELIEQVS-GVQTEPDSPPTIKVLVLEATTPVSAETATADPGENLAKMATASNT 1092
                 .:.:..||..:::| ..:|...|..|.|....|.:.|:|.|...|.|     ::.|:...
Human   685 -----KIMQWIIEGEKEISRHRRTGHGSSGTRKPQPHENSRPLSLEHPWAGP-----QLRTSVQP 739

  Fly  1093 TTITTDDQAMRADDDAERAAEIEQTVLDELSPTTDEYQEFGDAKDAVDDFDSIDIGYIPPAPTPA 1157
            :.:...|..|                                                ||.|.|.
Human   740 SHLFIQDPTM------------------------------------------------PPHPAPN 756

  Fly  1158 P------------------SMAPLAELDVDTV--DDEPC-EPAAPPPSHSAPASSSSRELVMASG 1201
            |                  |.||..:..|..|  ....| .||..|..|..|| .|..||
Human   757 PLTQLEEARRRLEEEEKRASRAPSKQRYVQEVMRRGRACVRPACAPVLHVVPA-VSDMEL----- 815

  Fly  1202 SVTATPTSSNEEARKRRK 1219
                    |..|.|.:||
Human   816 --------SETETRSQRK 825

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42450	NP_001259691.1	DEP_RGS7-like	219..306	CDD:239897
		RGS_DHEX	303..401	CDD:375589
		G-gamma	418..482	CDD:459879	6/27 (22%)
		RGS_R7-like	494..614	CDD:188660	31/135 (23%)
AXIN1	XP_011520984.1	Axin_TNKS_binding	60..129	CDD:211424	5/15 (33%)
		RGS_Axin	138..258	CDD:188662	29/128 (23%)
		Axin_b-cat_bind	519..550	CDD:462616	2/30 (7%)
		DIX	836..912	CDD:459936