Protein Alignment CG42450 and RGS2

DIOPT Version :10

• Sequence 1: NP_001259691.1
• Gene: CG42450 / 32874
• FlyBaseID: FBgn0259927
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: NP_002914.1
• Gene: RGS2 / 5997
• HGNCID: 9998
• Length: 211
• Species: Homo sapiens
• Alignment Length: 196
• Identity: 53/196 - (27%)
• Similarity: 100/196 - (51%)
• Gaps: 16/196 - (8%)

  Fly   426 RDVDYLGKSLNRTRMKMSQACESLVCYSETFSEYDFFLQ----PALPSNPWVTEDIAFWQLNNTF 486
            |.:|....|.:::..|..:...:|:  .:..:...:|||    |..|.....::..||.:
Human    14 RPMDKSAGSGHKSEEKREKMKRTLL--KDWKTRLSYFLQNSSTPGKPKTGKKSKQQAFIK----- 71

  Fly   487 VDIPTEKRVKRWAISIEELVSDPTGLQEFTGFLEKEYSHENIRFWIAVNRLRRSAHSQ-VARKVN 550
               |:.:..:.|:.:.:||::...||..|..||:.|:..|||.||:|....:::...| ::.|..
Human    72 ---PSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKAR 133

  Fly   551 EIYEEFLKPGAPCEINIDGKTMESVLKGLKNPSRFTFDSASEHIYMLLLKKDCYPRFIRSEHYKR 615
            :||.:|::..||.|||||.:|...:.:.::..:...|.:|.:.:|. |::.:.||||:.||.|:.
Human   134 KIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYS-LMENNSYPRFLESEFYQD 197

  Fly   616 L 616
            |
Human   198 L 198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42450	NP_001259691.1	DEP_RGS7-like	219..306	CDD:239897
		RGS_DHEX	303..401	CDD:375589
		G-gamma	418..482	CDD:459879	12/59 (20%)
		RGS_R7-like	494..614	CDD:188660	38/120 (32%)
RGS2	NP_002914.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	14..33		4/18 (22%)
		Necessary for membrane association. /evidence=ECO:0000269|PubMed:11278586	32..66		6/35 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	49..68		4/18 (22%)
		Necessary to inhibit protein synthesis. /evidence=ECO:0000269|PubMed:19736320	79..116		14/36 (39%)
		RGS_RGS2	84..197	CDD:188664	38/113 (34%)