Protein Alignment CG42450 and rgs12a

DIOPT Version :10

• Sequence 1: NP_001259691.1
• Gene: CG42450 / 32874
• FlyBaseID: FBgn0259927
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: XP_699097.5
• Gene: rgs12a / 570516
• ZFINID: ZDB-GENE-030131-2614
• Length: 1371
• Species: Danio rerio
• Alignment Length: 1160
• Identity: 237/1160 - (20%)
• Similarity: 374/1160 - (32%)
• Gaps: 400/1160 - (34%)

  Fly    40 TPNPQSSAQAQLSLVPSKPTSLSLQPH--AVLQA------------MQQLSPSAGGNNNASSTAA 90
            ||:|.:.:..:.   |..|.|:|   |  :||.|            :...:|..|..|..:|.:.
Zfish   358 TPDPDTQSCLEF---PQTPHSIS---HFISVLYADMGDYIEKLRLKLDSENPDEGSQNARNSGSG 416

  Fly    91 TATSSSSGNANSGSSPALASTATAISATTQAATAFSGSSVGHHHLQHHHQHTHPHAPQQSQSQQP 155
            :.:.|..|||:.....:|.           ...:|:..::.:....::.||      :.|...:|
Zfish   417 SGSDSGIGNASPEERDSLI-----------GQWSFTSPNICNPPPPYYSQH------RNSTFLKP 464

  Fly   156 QPQHQLQQP--------HPAGAPSSATQSHHHGSISVSGSGGGLLGSSGGSGNQQQAIE-----K 207
            :.:..|.:|        .|:|.|:.|..|   ....|..|....|.....:|.::.:|.     :
Zfish   465 ECRCLLSEPLTGSAQPATPSGVPAGADGS---AFTPVPLSKQSNLPPKQRAGQRRPSIGLKARWQ 526

  Fly   208 LSRPMAFDKMEMLVREMQDQEHGVPVRQQKMFLTSIPYAFMGYDLIEWLMDRLQIEESEALNIAN 272
            .|||   :.:|.||....|        ..|...:::|.|......:.:    ..:|.::.:|...
Zfish   527 KSRP---NSIECLVEGDND--------DPKSKCSTLPPAMEQIPTLRY----KPLEHTQKINFTP 576

  Fly   273 QLCLHGYFFPVNDSKTLTVKDDSSLYRFQTPYYWPWQHKAPDNVEYAIYLAKRSLRNKQ------ 331
            ||.|...||    |.....||..:    :...:|            |:...:.|:|...
Zfish   577 QLELTSRFF----SSAAKQKDGEN----KGSLFW------------ALTRGRSSVRRPSGPAKRL 621

  Fly   332 --RHALEDYEAEALASLHKNLKGKWDFISMQAEEQVRLAKERKKGDKIVGDSQERAYWRVHRPPP 394
              .|:|.|.|:.|                             ..|::..|..|..
Zfish   622 SLAHSLNDLESAA-----------------------------SDGERSGGGVQRH---------- 647

  Fly   395 GQFTPLEPCPVPSRDRQGLKPNKKKTVDDMQRDVDYLGKSLNRTRMKMSQACESLVCYSETFSEY 459
                  :...|.|.|..|
Zfish   648 ------DCSSVSSLDSNG----------------------------------------------- 659

  Fly   460 DFFLQPALPSNPWVTEDIAFWQLNNTFVDIPTEKRVKRWAISIEELVSDPTGLQEFTGFLEKEYS 524
                  :|||   ||....|           ||:||..||:|.|.|:.||.|::.|:.||:||:|
Zfish   660 ------SLPS---VTNHCRF-----------TERRVALWAVSFERLLQDPVGVRYFSEFLKKEFS 704

  Fly   525 HENIRFWIA---VNRLRRSAHSQVARKVNEIYEEFLKPGAPCEINIDGKTM--ESVLKG-----L 579
            .|||.||.|   .:::......|:::|..|||..||...|...:|||.:..  :.||..     .
Zfish   705 EENILFWQACECFSQVPEHDKKQLSQKAKEIYNRFLSSKATMPVNIDSQAQLADDVLTAPQPNMF 769

  Fly   580 KNPSRFTFDSASEHIYMLLLKKDCYPRFIRSEHYKRLLDTGIQ-------------PSYKKRFF- 630
            |.|....|:         |:|.|.|.||::|..|:..:...::             |:..|..|
Zfish   770 KQPQLQIFN---------LMKMDSYARFLKSTLYQECMLAEVEGRPLPDPCPIPCSPAPSKHSFT 825

  Fly   631 ----NFGGVSGAKKKMTAALSS---QPNLGDAAKG-------PSGTSAGSSMMQAPP-PGNLARR 680
                .|.......:|.....||   :....|...|       || ...|....:||. |.:...|
Zfish   826 SDRSTFSTPKKENRKPKTGRSSDDLREKHSDKKNGFFSWYRYPS-IGKGQKKREAPDLPYHCNGR 889

  Fly   681 RGSDRSL-TGSAHELAVI---GVNKDA---GSKVPHSHSQSNLS-------------EIPFSSDS 725
            |.|..|| :|::.||...   |.|:..   ||.......:...|             .||....:
Zfish   890 RESQGSLSSGASQELNTSCSGGKNEQCELRGSSCALDKERERCSRTCTVTLPDGSSCSIPLRQGA 954

  Fly   726 IYRGDM----PQRHMAIMDIGIYAAYG---------------------------------NRESS 753
            ..|..:    .::|:.:..:.::...|                                 ||...
Zfish   955 SIRQVLLELCQKQHINLAAVDLFLTGGEKPLVLDQDSITLSSRELRLEKRTLFRLDLVPINRSVG 1019

  Fly   754 LQALPETPKT-----------------------KTTVLDATESTSSSTALAAAASSAVCPWDDPA 795
            |:|.|..|.|                       :|.|||.....|:...|......|     |||
Zfish  1020 LKAKPTKPVTEVLRPVVAKYGLQLGDLVARISGETEVLDLGVPISNLDGLRVVLERA-----DPA 1079

  Fly   796 -----ESVPPPPPPAQVKLSVCPWEL-DSATETPTAA------PAVGSGGGGAGASKILSSTGQP 848
                 :::....|.|:...   |.|. |::|..|..|      |...:.....|....:..|.:.
Zfish  1080 KAEKSKTLNSKTPAAKKGF---PRERDDNSTVKPLKADVEDKHPRTAASERKKGKKNHIDETEEF 1141

  Fly   849 MRLNSTSSDNSDVNDRMQRNLGIRHQNTVDSGEAGIKRLIPNIPEQRRASVSFTPSP-------T 906
            ..|.| .:.:|.|:|  ||.| :|.::.|             :|:..|  |:..|.|       |
Zfish  1142 FELLS-RAQSSRVDD--QRGL-LRKEDLV-------------LPDFLR--VNNDPKPQSPPSCST 1187

  Fly   907 P-DFQLGRTPTTTSSPTVAPSSSTPLQARSAVYGSGQGIAKDPPSGSDVDAELEEELNKISL-GE 969
            | ..:.|.|.||:::|  .|...:|.....|.......::....|....:.|.||.|..::| .|
Zfish  1188 PTSHKPGHTTTTSTNP--HPPKPSPCNGHQASAPFSAPLSPILRSAGAREQEEEEGLGDLTLVAE 1250

  Fly   970 SSISEP-PLLVVPTPEQTPPPI------TKITPPPG------ESENQADQVIDST 1011
            ..||.| ..|:.|.|..:|||.      ...||||.      |.||.:...::|:
Zfish  1251 GDISSPNSTLLPPPPPVSPPPYDGSLAEANFTPPPAVHGTGTEEENTSTSAVNSS 1305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42450	NP_001259691.1	DEP_RGS7-like	219..306	CDD:239897	16/86 (19%)
		RGS_DHEX	303..401	CDD:375589	12/105 (11%)
		G-gamma	418..482	CDD:459879	6/63 (10%)
		RGS_R7-like	494..614	CDD:188660	45/129 (35%)
rgs12a	XP_699097.5	None