Protein Alignment CG42450 and Rgs3

DIOPT Version :10

• Sequence 1: NP_001259691.1
• Gene: CG42450 / 32874
• FlyBaseID: FBgn0259927
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: XP_017449084.1
• Gene: Rgs3 / 54293
• RGDID: 3566
• Length: 1144
• Species: Rattus norvegicus
• Alignment Length: 674
• Identity: 154/674 - (22%)
• Similarity: 235/674 - (34%)
• Gaps: 207/674 - (30%)

  Fly     3 PPG-GVPPDRDRQLVLRNQSAALVPVVVSAPATG---PGATTPNPQSSAQAQLSLVPSKPTSLSL 63
            ||| .:||.:|     .:.|..|.|        |   |.:..|:|.........|.|||..|
  Rat   612 PPGQELPPSKD-----PSPSQELPP--------GQDLPPSKDPSPSQELPPGQELPPSKDPS--- 660

  Fly    64 QPHAVLQAMQQLSPSAGGNNNASSTAATATSSSSGNANSGSSPALASTATA--------ISATTQ 120
             |...|.|.|.|.|.....:...:.....:.||...|...:.|....|:|:        .|.||:
  Rat   661 -PSQELPAGQDLPPRKESFSGQEAAPGPESPSSEDIATCQNPPQSPETSTSKDSPPGQGSSPTTE 724

  Fly   121 AATAFSGSSVGHHHLQHHHQHTHPHAPQQSQSQQPQPQHQLQQPHPAGAPSSATQSH-------- 177
            ..:. .|...|                |:|.||.|    .|.|..||...|||:..:
  Rat   725 VPSC-QGLPAG----------------QESTSQDP----LLSQEPPAIPESSASDQNVLPSQESP 768

  Fly   178 -HHGSISVSG------SGGGLLGSSGGSGNQQQAIEKLSRPMAFDKMEMLVREM--------QDQ 227
             ..||:|...      |.|.|..::.|.       ...|||      ..::.|:        ||.
  Rat   769 PSQGSLSEKALAEQTISPGELPAATAGE-------PSASRP------NFVIPEVRLDSAYSQQDG 820

  Fly   228 EHGVPVRQQKMFLTSIPYAFMGYDLIEWLMDRLQIEESEALNIANQLCLHGYFFPVNDSKTLTVK 292
            .||               ...|.|     .|..:.||.|.              ...|.:..|..
  Rat   821 AHG---------------GSSGED-----EDAEEGEEGEE--------------GEEDEEDDTSD 851

  Fly   293 DD---------SSLYRFQTPYYWPWQHKAPDNVEYAIYLAKRSLRNKQRHA----LEDYEAEALA 344
            |:         |||.            :.....|..:.|..::...::.|:    |::......|
  Rat   852 DNYGDRNEAKRSSLI------------ETGQGAEGGLSLRVQNSLRRRTHSEGSLLQEARGPCFA 904

  Fly   345 S---LH----KNLKGKWDFISMQAEEQVRLAKERKKGDKIVGDSQER--AYWRVHRPPPGQFTPL 400
            |   ||    :.....|...|.:.     |.||..:.    |.|...  .::..||...|  |.|
  Rat   905 SDTTLHCSDGEGTTSTWAIPSPRT-----LKKELGRN----GGSMHHLSLFFTGHRKMSG--TDL 958

  Fly   401 EPCPVPSRDRQGLKPNKKKTVDDMQRDVDYLGKSLNRTRMKMSQACESLVCYSETFSEYDFFLQP 465
            ......||.|:     .|....||:..:     ::.|.|.:...|                  ||
  Rat   959 ADDVEASRKRK-----SKNIAKDMKNKL-----AIFRRRNESPGA------------------QP 995

  Fly   466 ALPSNPWVTEDIAFWQLNNTFVDIPTEKRVKRWAISIEELVSDPTGLQEFTGFLEKEYSHENIRF 530
            |..::          :...:|.  ||.:...:|:.|:|:|:....||:.|..||..|:|.||:.|
  Rat   996 AGKAD----------KTTKSFK--PTSEEALKWSESLEKLLLHKYGLEVFQAFLRTEFSEENLEF 1048

  Fly   531 WIAVNRLRR-SAHSQVARKVNEIYEEFLKPGAPCEINIDGKTMESVLKGLKNPSRFTFDSASEHI 594
            |:|....:: .:.|::|.|..:|:.||:...|..|:|:|..|.|...:.|::.:|..||.|.:.|
  Rat  1049 WLACEDFKKVKSQSKMAAKAKKIFAEFIAIQACKEVNLDSYTREHTKENLQSITRGCFDLAQKRI 1113

  Fly   595 YMLLLKKDCYPRFIRSEHYKRLLD 618
            :. |::||.||||:||:.|..|::
  Rat  1114 FG-LMEKDSYPRFLRSDLYLDLIN 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42450	NP_001259691.1	DEP_RGS7-like	219..306	CDD:239897	17/103 (17%)
		RGS_DHEX	303..401	CDD:375589	19/110 (17%)
		G-gamma	418..482	CDD:459879	9/63 (14%)
		RGS_R7-like	494..614	CDD:188660	43/120 (36%)
Rgs3	XP_017449084.1	C2_RGS-like	35..154	CDD:176067
		PDZ_RGS3-like	194..270	CDD:467195
		PHA03307	578..>802	CDD:223039	55/234 (24%)
		RGS_RGS3	1020..1133	CDD:188668	42/113 (37%)