Protein Alignment CG42450 and Rgs12

DIOPT Version :10

• Sequence 1: NP_001259691.1
• Gene: CG42450 / 32874
• FlyBaseID: FBgn0259927
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: XP_006251413.1
• Gene: Rgs12 / 54292
• RGDID: 3564
• Length: 1457
• Species: Rattus norvegicus
• Alignment Length: 933
• Identity: 190/933 - (20%)
• Similarity: 310/933 - (33%)
• Gaps: 307/933 - (32%)

  Fly   392 PPPGQFTPLE-----------PCPVPSRDRQ----------GLKPNKKKTVDDMQRDVDYLGKSL 435
            |||....|.:           |.....||..          |...|.:||.:|.:......|.:|
  Rat   573 PPPMSKIPADRYRVEGSFAQAPLSTQKRDWSRKAFGMQNLFGPHRNVRKTKEDKKSSKLGRGVAL 637

  Fly   436 NRTRMKMS--QACESLVCYSETFSEYDFFLQPALPSNPWVT-EDIAFWQLNNTF---VDIPT--- 491
            .:|..:.|  ::......:|.|.|..|  |:.|..|:..:| .|:.....||:.   ..:|:
  Rat   638 AQTSQRTSARRSFGRSRRFSLTRSLDD--LESATVSDGELTGADLKDCISNNSLSSNASLPSVQS 700

  Fly   492 -----EKRVKRWAISIEELVSDPTGLQEFTGFLEKEYSHENIRFWIAVNRLRR-SAH--SQVARK 548
                 |:||..||:|.|.|:.||.|::.|:.||.||:|.|||.||.|...... .||  .:::.:
  Rat   701 CRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACECFSHVPAHDKKELSYR 765

  Fly   549 VNEIYEEFLKPGAPCEINIDGKTM--ESVLKGLKNPSRFTFDSASEHIYMLLLKKDCYPRFIRSE 611
            ..||:.:||...|...:|||.:..  :.:|..   |....|......|:. |:|.|.|.||::|:
  Rat   766 AREIFSKFLCSKATTPVNIDSQAQLADDILNA---PHPDMFKEQQLQIFN-LMKFDSYTRFLKSQ 826

  Fly   612 HYKRLL--------------------------------------------------DTGIQPSYK 626
            .|:..:                                                  |.|.:.|.|
  Rat   827 LYQECVLAEVEGRTLPDSQQVPSSPASKHSISSDHSNVSTPKKLSGKSKSGRSLNEDVGEEDSEK 891

  Fly   627 KR---FFNF--------------------------GGVSGAKKKMTAALSSQPNLGDAAKG---- 658
            ||   ||::                          ||:...:.:.:.:.:...:|.:|.:.
  Rat   892 KRKGAFFSWSRSRSTGRSQKKKDHGDHAHDALHANGGLCRRESQGSVSSAGSLDLSEACRTSALE 956

  Fly   659 ------------PSGTS------AGSSMMQAPPPGNLARRRGSDRSLTGSAHELAVIGVNKDAGS 705
                        |.|||      :|.|:.:.  ...|..|.|    :.|:|.:|.::|     |.
  Rat   957 RDKAAKHCCVHLPDGTSCVVAVKSGFSIKEI--LSGLCERHG----INGAAVDLFLVG-----GD 1010

  Fly   706 KVPHSHSQSNL---SEIPFSSDSIYRGDMPQRHMAIMDIGIYAAYGNRESSLQALPETPKTKT-- 765
            |....|..|::   .::.....:::|.|:         :.|     ||...|:|.|..|.|:.
  Rat  1011 KPLVLHQDSSILATRDLRLEKRTLFRLDL---------VPI-----NRSVGLKAKPTKPVTEVLR 1061

  Fly   766 -----------TVLDATESTSSSTALAAAASSAVCPWDDPAESVPPPPPPAQVKLSV-----CPW 814
                       ::|...........|.|..||.     |....:.....|::.|:|.     .|.
  Rat  1062 PVVAKYGLDLGSLLVRLSGEKEPLDLGAPISSL-----DGQRVILEERDPSRGKVSTEKQKGAPV 1121

  Fly   815 ELDSA-TETPTAAPAVGSGG--GGAGASKILSSTGQPM---RLNSTSSDNSDVNDRMQRNLGI-- 871
            :..|| ..:|....|:|...  |.:.:.||....|:..   ||:......:.:..:..:.:.:
  Rat  1122 KQSSAVNSSPRNHSAMGEERTLGKSNSIKIRGENGKSARDPRLSKREESIAKIGKKKYQKINLDE 1186

  Fly   872 ---------RHQNTVDSGEAGIKR----LIPNI----PEQRRASVSFTPSPTPDF---------Q 910
                     :.|:.....:.|:.|    ::|..    |.....::| :|.|...|         |
  Rat  1187 AEEFFELISKAQSNRADDQRGLLRKEDLVLPEFLRLPPGSSELALS-SPPPVKGFSKRAVTSHGQ 1250

  Fly   911 LGRTPTTTS---SPTVAPSSS-TPLQARSAVYGSGQGIAKDP--------PSGSDVDAEL----- 958
            .|...|..|   ||..:|:|: :|..|.|.......|.|..|        |.|:....|.
  Rat  1251 EGAVQTEESYSDSPATSPASAQSPCSAYSPGSAHSPGSAHSPGSAHSTPGPPGTAQPGEKPTKPS 1315

  Fly   959 -----------------------------EEELNKISL-GESSISEPPLLVVPTPEQTPPPITKI 993
                                         ||::..::| ||..||.|...::|     |||:.:.
  Rat  1316 CISTVQEGTTQAWRRLSPELEAGGIQTVEEEQVADLTLMGEGDISSPNSTLLP-----PPPLPQD 1375

  Fly   994 TPPP--------GESENQADQVIDSTEI----PGSSCSTQANQFGEATATVTTVKEVQIE--LIE 1044
            ||.|        |......:::||...:    ||...|....|.|.        :.|:..  .:.
  Rat  1376 TPGPTRPGGRARGSEGLPVNRIIDVDLVTGVPPGWGGSILGVQLGP--------RRVKANGPFLP 1432

  Fly  1045 QVSGVQTEPDSPPTIKVLVLEAT 1067
            ...|..|.|..|...|.....||
  Rat  1433 NGPGQSTIPGEPTKPKASTHHAT 1455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42450	NP_001259691.1	DEP_RGS7-like	219..306	CDD:239897
		RGS_DHEX	303..401	CDD:375589	4/8 (50%)
		G-gamma	418..482	CDD:459879	16/66 (24%)
		RGS_R7-like	494..614	CDD:188660	43/124 (35%)
Rgs12	XP_006251413.1	PDZ_RGS12-like	20..95	CDD:467194
		PTB_RGS12	227..358	CDD:269984
		RGS_RGS12	716..830	CDD:188696	39/117 (33%)
		RGS12_us1	836..953	CDD:465199	12/116 (10%)
		RBD1_RGS12	962..1031	CDD:340656	17/79 (22%)
		Ubl1_cv_Nsp3_N-like	1032..1104	CDD:475130	16/90 (18%)
		RGS12_us2	1106..1180	CDD:435461	15/73 (21%)
		GoLoco	1188..1209	CDD:214645	2/20 (10%)
		RGS12_usC	1238..1387	CDD:465198	33/153 (22%)