Protein Alignment CG42450 and Rgs3

DIOPT Version :10

• Sequence 1: NP_001259691.1
• Gene: CG42450 / 32874
• FlyBaseID: FBgn0259927
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: XP_006538120.1
• Gene: Rgs3 / 50780
• MGIID: 1354734
• Length: 1143
• Species: Mus musculus
• Alignment Length: 683
• Identity: 150/683 - (21%)
• Similarity: 233/683 - (34%)
• Gaps: 226/683 - (33%)

  Fly     3 PPG-GVPPDRDRQLVLRNQSAALVPVVVSAPATG--PGATTPNPQSSAQAQLSLVPSKPTSLSLQ 64
            ||| .:||.:|     .:.|..|       ||..  |.:..|:|.....|...|.|||..|
Mouse   612 PPGQDLPPSKD-----PSPSQEL-------PAGQDLPPSKDPSPSQELPAGQDLPPSKDPS---- 660

  Fly    65 PHAVLQAMQQLSP--------SAGGNNNASS----TAATATSSSSGNANSGSSPALASTATAISA 117
            |...|...|.|.|        :|.|..:.||    |......|...:.:..|.|...|:.|....
Mouse   661 PSQELPVGQDLPPRKDSSGQEAAPGPESPSSEDIATCPKPPQSPETSTSKDSPPGQGSSPTTELP 725

  Fly   118 TTQAATAFSGSSVGHHHLQHHHQHTHPHAPQQSQSQQPQ-------------PQHQL-QQPHPAG 168
            :.|...|...|:.....|...    .|..|:.|.|.|.:             |:..| :|...:|
Mouse   726 SCQGLPAGQESTSQDPLLSQE----PPVIPESSASVQKRLPSQESPSSLGSLPEKDLAEQTISSG 786

  Fly   169 APSSATQSHHHGSI--------------------SVSGSGGGLL--------GSSGGSGNQQQAI 205
            .|..||     |::                    .:.|:.||..        |..||.|.:.:.
Mouse   787 EPPVAT-----GAVLPASRPNFVIPEVRLDNAYSQLDGAHGGSSGEDEDAEEGEEGGEGEEDEE- 845

  Fly   206 EKLSRPMAFDKME----MLVREMQDQEHGVPVRQQKMFLTSIPYAFMGYDLIEWLMDRLQ----- 261
            :..|.....|:.|    .|:...|..|.|..:|.|..                 |..|..
Mouse   846 DDTSDDNYGDRSEAKRSSLIETGQGAEGGFSLRVQNS-----------------LRRRTHSEGSL 893

  Fly   262 IEESEALNIANQLCLHGYFFPVNDSKTLTVKDDSSLYRFQTPYYWPWQHKAPDNVEYAIYLAKRS 326
            ::||.....|:...||     .:|.:..|.               .|...:|           |:
Mouse   894 LQESRGPCFASDTTLH-----CSDGEGATS---------------TWAIPSP-----------RT 927

  Fly   327 LRNKQRHALEDYEAEALASLHKNLKGKWDFISMQAEEQVRLAKERKKGDKIVGDSQERAYWRVHR 391
            |:.:               |.:| .|....:|:                          ::..||
Mouse   928 LKKE---------------LGRN-GGSMHHLSL--------------------------FFTGHR 950

  Fly   392 PPPGQFTPLEPCPVPSRDRQGLKPNKKKTVDDMQRDVDYLGKSLNRTRMKMSQACESLVCYSETF 456
            ...|  |.|..|...||.|:     .|....||:..:     ::.|.|.:...|
Mouse   951 KMSG--TDLTECDEASRKRK-----SKNIAKDMKNKL-----AIFRRRNESPGA----------- 992

  Fly   457 SEYDFFLQPALPSNPWVTEDIAFWQLNNTFVDIPTEKRVKRWAISIEELVSDPTGLQEFTGFLEK 521
                   |||..::          :...:|.  ||.:...:|:.|:|:|:....||:.|..||..
Mouse   993 -------QPASKTD----------KTTKSFK--PTSEEALKWSESLEKLLLHKYGLEVFQAFLRT 1038

  Fly   522 EYSHENIRFWIAVNRLRR-SAHSQVARKVNEIYEEFLKPGAPCEINIDGKTMESVLKGLKNPSRF 585
            |:|.||:.||:|....:: .:.|::|.|..:|:.||:...|..|:|:|..|.|...:.|::.:|.
Mouse  1039 EFSEENLEFWLACEDFKKVKSQSKMAAKAKKIFAEFIAIQACKEVNLDSYTREHTKENLQSITRG 1103

  Fly   586 TFDSASEHIYMLLLKKDCYPRFIRSEHYKRLLD 618
            .||.|.:.|:. |::||.||||:||:.|..|::
Mouse  1104 CFDLAQKRIFG-LMEKDSYPRFLRSDLYLDLIN 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42450	NP_001259691.1	DEP_RGS7-like	219..306	CDD:239897	15/91 (16%)
		RGS_DHEX	303..401	CDD:375589	12/97 (12%)
		G-gamma	418..482	CDD:459879	9/63 (14%)
		RGS_R7-like	494..614	CDD:188660	43/120 (36%)
Rgs3	XP_006538120.1	C2_RGS-like	35..154	CDD:176067
		PDZ_RGS3-like	194..270	CDD:467195
		PHA03307	578..>801	CDD:223039	51/213 (24%)
		RGS_RGS3	1019..1132	CDD:188668	42/113 (37%)