Protein Alignment CG42450 and Rgs6

DIOPT Version :10

• Sequence 1: NP_001259691.1
• Gene: CG42450 / 32874
• FlyBaseID: FBgn0259927
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: XP_011242435.1
• Gene: Rgs6 / 50779
• MGIID: 1354730
• Length: 552
• Species: Mus musculus
• Alignment Length: 555
• Identity: 210/555 - (37%)
• Similarity: 314/555 - (56%)
• Gaps: 77/555 - (13%)

  Fly   197 GSGNQQQ---AIEKLSRP--MAFDKMEMLVREMQDQE-HGVPVRQQKMFLTSIPYAFMGYDLIEW 255
            |||:|:.   |..:.|.|  :.:.|:|.::.:|||.: .|||:|..|.||:.||....|.|:::|
Mouse     4 GSGDQRAVGIADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQW 68

  Fly   256 LMDRLQIEES-EALNIANQLCLHGYFFPVNDSKTLTVKDDSSLYRFQTPYYWP---WQHKAPDNV 316
            ||..|.||:. ||:::.:.:...||.||::| ..||:|||.:.||||.||:||   |:   |:|.
Mouse    69 LMKNLSIEDPVEAIHLGSLIAAQGYIFPISD-HVLTMKDDGTFYRFQAPYFWPSNCWE---PENT 129

  Fly   317 EYAIYLAKRSLRNKQRHALEDYEAEALASLHKNLKGKWDFISMQAEEQVRLAKERKKGDKIVGDS 381
            :|||||.||:::||.|..|.|||||.||.|.:....||:||.||||.||::.:::.|.::.:.||
Mouse   130 DYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDS 194

  Fly   382 QERAYWRVHRPPPGQFTPLE------------------------------PCPVPSRDRQGLKPN 416
            ||||:|.||||.||.....|                              |..:||      :|.
Mouse   195 QERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTDETQSQSPVHIPS------QPI 253

  Fly   417 KKKTVDDMQRDVDYLGKSLNRTRMKMSQACESLVCYSETFSEYDFFLQPALPSNPWVTEDIAFWQ 481
            :|.|.||:::.:.:|...::|..:|||:..|||:.|:|.:.|||.|:.||.|||||:::||..|.
Mouse   254 RKTTKDDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPFITPAEPSNPWISDDITLWD 318

  Fly   482 LNNTFVDIPTEKRVKRWAISIEELVSDPTGLQEFTGFLEKEYSHENIRFWIAVNRLRRSAHSQVA 546
            :..:  ..|:::|||||..|.:|::.|..|..:|..|||.|:|.||:|||::|..|::.....||
Mouse   319 IEMS--KEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLSVQDLKKQPLQDVA 381

  Fly   547 RKVNEIYEEFLKPGAPCEINIDGKTMESVLKGLKNPSRFTFDSASEHIYMLLLKKDCYPRFIRSE 611
            ::|.||::|||.||||..||:|..:.|...:.:|:..|:||:.|.||||. |:|.|.|.||:||.
Mouse   382 KRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYK-LMKSDSYARFLRSN 445

  Fly   612 HYKRLL--------DTGIQPSYKKRFFNFGGVSGAKKKMTAALSSQ----PNLGDAAKGPSGTSA 664
            .|:.||        :.|.:.|.:|  |........:.:|.||...:    |.:|..|.|.:....
Mouse   446 AYQDLLLAKKKPESEQGRRTSLEK--FTRSVCCWRRVRMAAAFHPRGGFLPAVGKVAGGQAPYGP 508

  Fly   665 GSSMMQAPPPG-------NLARRR--GSDR-SLTG 689
            .:.::.||.||       :..|||  .:|| ||.|
Mouse   509 DAVLLTAPTPGPGPGPTEDPGRRRSTSNDRASLRG 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42450	NP_001259691.1	DEP_RGS7-like	219..306	CDD:239897	38/88 (43%)
		RGS_DHEX	303..401	CDD:375589	50/100 (50%)
		G-gamma	418..482	CDD:459879	28/63 (44%)
		RGS_R7-like	494..614	CDD:188660	55/119 (46%)
Rgs6	XP_011242435.1	DEP_RGS7-like	31..119	CDD:239897	38/88 (43%)
		RGS_DHEX	116..217	CDD:375589	51/103 (50%)
		GGL	258..319	CDD:128520	26/60 (43%)
		RGS_RGS6	328..452	CDD:188691	57/124 (46%)