DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42450 and Axn

DIOPT Version :9

Sequence 1:	NP_001259691.1	Gene:	CG42450 / 32874	FlyBaseID:	FBgn0259927	Length:	1280	Species:	Drosophila melanogaster
Sequence 2:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster

Alignment Length:	788	Identity:	147/788 - (18%)
Similarity:	248/788 - (31%)	Gaps:	242/788 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   492 EKRVKR------------------WAISIEELVSDPTGLQEFTGFLEKEYS--HENIRFWIAVNR 536
            |.|||:                  ||.::..|:.|..|::.|..::|:|..  ::::.|:.|...
  Fly    27 ESRVKKMTEGVADTSKNSSPSYLNWARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEG 91

  Fly   537 LRRSAHSQVARKVNEIYEEFLKPGAPCEINIDGKTMESVLKGLK-NP----SRFTFDSASEHIYM 596
            |::....:..:::......||:..   :::| ...:.:.:|.:| ||    |...||....|: .
  Fly    92 LKQQTDPEKIKQIIGAIYRFLRKS---QLSI-SDDLRAQIKAIKTNPEIPLSPHIFDPMQRHV-E 151

  Fly   597 LLLKKDCYPRFIRSEHYKRLLDTGIQPSYKKRFFNFGGVSGAKKKMTAALSSQPNLGDAAKGPSG 661
            :.::.:.||.|:.||.|...:.   |.|.::......|.:|:....::........|..|..|:.
  Fly   152 VTIRDNIYPTFLCSEMYILYIQ---QMSAQQERCTSSGATGSGSAGSSGSGGSSLAGACALPPTT 213

  Fly   662 TSAGSSMMQAPPPGNLARRRGSDRSLTGSAHELAVIGVNKDAGSKVPHSHSQSNLSEIPFSSDSI 726
            .|....:.|..|||                   |.|.:...:.|..|.....        :|.|:
  Fly   214 ASGKQQLPQLVPPG-------------------AFINLPVSSVSGPPAGTCS--------ASGSV 251

  Fly   727 YRGDMPQRHMAIMDIGIYAAYGNRESSLQALPETPKTKTTVLDATESTSSSTALAAAASSAVCPW 791
            |.                             |.|..:.:..:.||::...|:.|......:|...
  Fly   252 YG-----------------------------PSTSASSSGSISATDTLPRSSTLPTLHEDSVLSL 287

  Fly   792 DDPAESVPPPPPPAQVKLSVCPWELDSATETPTAAPAVGSGGGGAGASKILSSTGQPMRLNSTSS 856
            .|..|.|                      :......::|||..||||    .:...|:||
  Fly   288 CDDFEKV----------------------QMQEGGGSLGSGSVGAGA----RAPDYPIRL----- 321

  Fly   857 DNSDVNDRM----QRNLGIR---------HQNTVDSGEAGIKRLIPNI-PEQRRASVSFTPSPTP 907
                ..|.:    :|.|.||         :.:|.::.      .:||. .:..|||||
  Fly   322 ----TRDLLIATQKRRLEIRPPGAHGYVYNPSTTNTS------YVPNSRVDSERASVS------- 369

  Fly   908 DFQLGRTPTTTSSPTVAPSSSTPLQARSAVYGSGQGIAKDPPSGSDVDAELEEELNKISLGESSI 972
              ..|||.:.|.|.:.......|...|.......:.|.:        .|...:|.|...
  Fly   370 --SGGRTDSDTMSISSCSMDGRPYIQRRHSSTESKAIRQ--------SAMANKETNTFQ------ 418

  Fly   973 SEPPLLVVP----------TPEQTPPPITKITPPPGESENQADQVIDSTE-IPGSSCSTQANQFG 1026
                  |:|          .|.:....::.:.|...|.:.:.|....:.| .||::..|......
  Fly   419 ------VIPRTQRLHSNEHRPLKEEELVSLLIPKLEEVKRKRDLEERARERNPGAALLTNERSSA 477

  Fly  1027 EATATVTTVKEV--------QIELIEQVSGV---QTEPDSPPTIKVLVLEATTPVSAETATADPG 1080
            ...|....::|.        |..|.:.||.|   ||...||.|:...   ...|....|||.|.|
  Fly   478 SDRAFAEAIREKFALDEDNDQDILDQHVSRVWKDQTPHRSPGTMSPC---PPIPSRRRTATHDSG 539

  Fly  1081 -----------------ENLAKMATASNTTT-----ITTD--------DQAMRADDDAERAAEIE 1115
                             :::...::.|...|     :.||        |...:..|.:.|:....
  Fly   540 MVSDGAMSLSGHSMKHSKSMPDHSSCSRKLTNKWPSMNTDSGISMFSADTVTKYKDASSRSGSST 604

  Fly  1116 QTVLDELSPTTDEYQEFGDAKDAVDDFDSIDIGYIPPAPTPAPSMAPLAELDVDTVDDEPCEPAA 1180
            .:.|:|             ||..::|.......|..| |....|..|||.....:.......|..
  Fly   605 ASKLEE-------------AKRRLEDEPRRSRRYAQP-PMQHLSQQPLASFSSSSSGGSISLPHQ 655

  Fly  1181 PPPSHSAP 1188
            |||..:.|
  Fly   656 PPPLPAKP 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42450	NP_001259691.1	DEP_RGS7-like	219..306	CDD:239897
		G-gamma	422..482	CDD:279025
		RGS_R7-like	494..614	CDD:188660	30/144 (21%)
Axn	NP_733336.1	RGS	55..170	CDD:295367	26/119 (22%)
		Axin_b-cat_bind	494..543	CDD:285982	16/51 (31%)
		DIX	665..739	CDD:279160
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810