Protein Alignment CG42450 and loco

DIOPT Version :10

• Sequence 1: NP_001259691.1
• Gene: CG42450 / 32874
• FlyBaseID: FBgn0259927
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: NP_732773.1
• Gene: loco / 42672
• FlyBaseID: FBgn0020278
• Length: 1541
• Species: Drosophila melanogaster
• Alignment Length: 1532
• Identity: 297/1532 - (19%)
• Similarity: 463/1532 - (30%)
• Gaps: 587/1532 - (38%)

  Fly    44 QSSAQAQLSLVPSKPTSLSLQPHAVLQAMQQLSPSAGGNNNASSTAATATSSSSGNANSGSSPAL 108
            |...|..:.|:...|.|||||           |.|.|.....||......||||.:.|     ..
  Fly   285 QEKRQPTIVLMCITPDSLSLQ-----------SSSGGVLATYSSARLNFVSSSSESEN-----RF 333

  Fly   109 ASTATAISATTQ-----AATAFSGSSVGH--------------------HHLQHHHQ-------- 140
            ....|:....||     ..:|.|.::.||                    .|||..|:
  Fly   334 FGLVTSAVHNTQIEEEYEPSAGSAAAAGHISISHSCHVFVIDTKLIEHAQHLQRAHEFRLQCTRD 398

  Fly   141 -----------------------HTHPHAPQQSQSQQPQPQHQLQQPHPAGAPSS--------AT 174
                                   :|....|..|:|      ||......|||.::        :.
  Fly   399 PISNLCLEFPNNSEYVVNLVRSMYTMRILPPASRS------HQADYEAGAGAAAAGGAVAAAHSP 457

  Fly   175 QSHHHGSISV----SGSGGG----------------LLGSSGGSGNQQQA----IEKLSRPM--- 212
            |..:|..||.    |.||.|                .|.:..|:.....|    ....:||:
  Fly   458 QPSNHSEISTTTSNSDSGIGFNNDCTNISDRILVVDFLAAGAGAAAAAHAGPPTYPAPARPLGIV 522

  Fly   213 AFDKMEMLVREMQDQEHGVPVRQQKMFLTSI--PYAFMGYDLIEWLMDRLQIEESEALNI-ANQL 274
            ......:.||.|.|  |...:|.... .:|:  |.....::||          :|.|.|: :.:.
  Fly   523 GIPDNRLTVRAMPD--HSALLRSPPA-SSSLRRPNLLASFNLI----------QSPATNLTSTRS 574

  Fly   275 CLHGYFFPVNDS-KTLTV---KDDSSLYRFQTPYYWPWQHKAPDNVEYAIYLA---------KRS 326
            |.......|:|| :||..   .||.||            |.|..:::.....|         :||
  Fly   575 CDDVLNLFVDDSPRTLAAVASMDDISL------------HSAAPSLDEGHTFAHPACVPRKMRRS 627

  Fly   327 L-----------------RNKQRHALEDYEA--------------------EALASLHKNLKGKW 354
            |                 :...||:| .:||                    .:|.:|||:.|
  Fly   628 LALETPTTPHKLSAQVFGQPGSRHSL-GFEAIDSVQSSVSGACMDQTMDTWASLQNLHKSHK--- 688

  Fly   355 DFISMQAEEQVRLAKERKKGDKIVGDSQERAYWRVHRPPPGQFTPLEPCPVPSRDRQGLKPNKKK 419
            |..||.|........|....:..:|          :|..|...:|.       |...|....:..
  Fly   689 DRTSMSASSSSHCLLEATNSEPDLG----------NRALPANASPF-------RRAWGQSSFRTP 736

  Fly   420 TVDDMQRDVDYLGKSLNRTRMKMSQACESLVCYSETF----------SEYDFFL--------QPA 466
            ..|.:.::...||:| :..|...|........|.:|.          |::...|        .||
  Fly   737 RSDKVAKEQQQLGQS-SPVRRTASMNASDNDMYIKTLMLDSDLKSSRSQHQLSLLQVPKVLTTPA 800

  Fly   467 LPSNPWVTEDIAFWQLNNTFVD--IPTEKRVKRWAISIEELVSDPTGLQEFTGFLEKEYSHENIR 529
            .||.  :|..:|   ......|  .|:.     ||.|.|.::.|..|:|.|:.||:||:|.|||.
  Fly   801 PPSA--ITASVA---AEGAAQDHGCPSS-----WAGSFERMLQDAAGMQTFSEFLKKEFSAENIY 855

  Fly   530 FWIAVNRLR--RSAHSQVARKVNEIYEEFLKPGAPCEINIDGKTMESVLKGLKNPSRFTFDSASE 592
            ||.|..|.|  .|...:|| :..||:.:.|...:...:|:|.:......:.|.:.:...|..|.:
  Fly   856 FWTACERYRLLESEADRVA-QAREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPDIFAPAQK 919

  Fly   593 HIYMLLLKKDCYPRFIRSEHYKRLLDTGIQPSYKKRFFNFGGVSGAKKKMTAALSSQPNLGDAAK 657
            .|:. |:|.|.|.|||||:.||    :.::...|.:...:.|:.     :...|.:..:||
  Fly   920 QIFS-LMKFDSYQRFIRSDLYK----SCVEAEQKNQPLPYSGLD-----LDELLKTNFHLG---- 970

  Fly   658 GPSGTSAGSSMMQAPPPGNLARRRGSDRSLTGSAHELAVIGVNKDAGSKVPHSHSQSNLSEIPFS 722
                                                         |.||:..|.|.
  Fly   971 ---------------------------------------------AFSKLKKSASN--------- 981

  Fly   723 SDSIYRGDMPQRHMAIMDIGIYAAYGNRESSLQALPETPKTKTTVLDATESTSSSTALAAAASSA 787
                                   |...|..||  ||...||::...|.||       :.|....|
  Fly   982 -----------------------AEDRRRKSL--LPWHRKTRSKSRDRTE-------IMADMQHA 1014

  Fly   788 VCPWDDPAESVPPPPP--PAQVKLSVCPW----ELDSATETPTAAPAVGSGGGGAGAS------- 839
            :.    ||..||...|  .|.:|| ||..    :|.|:..:.::..| |:..||.|||
  Fly  1015 LM----PAPPVPQNAPLTSASLKL-VCGQNSLSDLHSSRSSLSSFDA-GTATGGQGASTESVYSL 1073

  Fly   840 -KILSSTGQPMRLNSTSSDN-SDVNDRM--QRNLGIRHQNTVDSG-----------------EAG 883
             :::.:.|....:.:...:. .::.:|:  :|||...:.:.|..|                 |..
  Fly  1074 CRVILTDGATTIVQTRPGETVGELVERLLEKRNLVYPYYDIVFQGSTKSIDVQQPSQILAGKEVV 1138

  Fly   884 IKRLIP---NIPEQRRASVSFTPSP---------------------------------------- 905
            |:|.:.   ::|:.:..||...|..
  Fly  1139 IERRVAFKLDLPDPKVISVKSKPKKQLHEVIRPILSKYNYKMEQVQVIMRDTQVPIDLNQPVTMA 1203

  Fly   906 ----------TPDFQLGRTPTTTSSPTVAPSSSTPLQARSAVYGSGQGIAKDPPSGSDVDAELEE 960
                      ..|||:|      ...::.|..|.|:              |..|.|     .|:|
  Fly  1204 DGQRLRIVMVNSDFQVG------GGSSMPPKQSKPM--------------KPLPQG-----HLDE 1243

  Fly   961 ELNKISLGESSISEPPLLVVPTPEQTPPPITKITPPPGESENQADQVIDSTEIPGSSCSTQANQF 1025
            ..||:      .:|  ||.                      ::||........|...||.::|:.
  Fly  1244 LTNKV------FNE--LLA----------------------SKADAAASEKSRPVDLCSMKSNEA 1278

  Fly  1026 GEATATVTTVKEVQIELIEQVSGVQTEPDSPPTIKVLVLE----ATTPVSAETAT----ADPGEN 1082
            ...|::          |.|::...|.:..:.|..|:..|:    :::..|.|.||    |||.:.
  Fly  1279 PSETSS----------LFERMRRQQRDGGNIPASKLPKLKKKSTSSSQQSEEAATTQAVADPKKP 1333

  Fly  1083 LAKMATASNTTTITTDDQAMRADDDAERAAEIEQTVLDELSPTTDEYQEFGDAKDAVDDFDSID- 1146
            :.....|.....:|            ||.||.:..:|:.|...  :.....|.:....:||..|
  Fly  1334 IIAKLKAGVKLQVT------------ERVAEHQDELLEGLKRA--QLARLEDQRGTEINFDLPDF 1384

  Fly  1147 -----------------------IGYIPPAPTPAPSMAPLAELDVD-------TVDDEP------ 1175
                                   :..:|..||..|..||...:...       .||.||
  Fly  1385 LKNKENLSAAVSKLRKVRASLSPVSKVPATPTEIPQPAPRLSITRSQQPVSPMKVDQEPETDLPA 1449

  Fly  1176 ----------CEPAAPPPSHSAPASSSSRELVMASGSV--TATPTSSNEEARKRRKKRNSEGKKL 1228
                      ..|..||.....|...|:..:...:|:.  ..:|:.....:.|...|..:...|:
  Fly  1450 ATQDQTEFAKAPPPLPPKPKVLPIKPSNWGVAQPTGNYCNKYSPSKQVPTSPKEASKPGTFASKI 1514

  Fly  1229 SSQDDKDKDAHERAGGSSMDAADHNAVCPWEDENVST 1265
            ..  |..:.:.|.||..          |.:.||..|:
  Fly  1515 PL--DLGRKSLEEAGSR----------CAYLDEPSSS 1539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42450	NP_001259691.1	DEP_RGS7-like	219..306	CDD:239897	23/93 (25%)
		RGS_DHEX	303..401	CDD:375589	25/143 (17%)
		G-gamma	418..482	CDD:459879	16/81 (20%)
		RGS_R7-like	494..614	CDD:188660	42/121 (35%)
loco	NP_732773.1	PDZ_RGS12-like	70..145	CDD:467194
		PTB_RGS12	251..391	CDD:269984	30/121 (25%)
		RGS_R12-like	828..941	CDD:188661	41/118 (35%)
		RBD1_RGS12_like	1072..1141	CDD:340515	9/68 (13%)
		RBD2_RGS12_like	1142..1212	CDD:340587	4/69 (6%)
		GoLoco	1354..1375	CDD:214645	3/22 (14%)