Protein Alignment CG42450 and rgs12b

DIOPT Version :10

• Sequence 1: NP_001259691.1
• Gene: CG42450 / 32874
• FlyBaseID: FBgn0259927
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: NP_999889.1
• Gene: rgs12b / 378970
• ZFINID: ZDB-GENE-031006-13
• Length: 1540
• Species: Danio rerio
• Alignment Length: 1439
• Identity: 285/1439 - (19%)
• Similarity: 454/1439 - (31%)
• Gaps: 482/1439 - (33%)

  Fly    40 TPNPQSSAQAQLSLVPSKPTSLSLQPHAVLQAMQQLSPSAG-------------GNNNASSTAAT 91
            ||:|.:....:.     .|||   ||  :||.:..|....|             |:.:|....:|
Zfish   377 TPDPDTGGCLEF-----PPTS---QP--LLQFVSVLYRDMGESIEGMRARAFLDGDLDAQQNNST 431

  Fly    92 ATSSSSGNAN--------------SGSSPALASTATAISATTQAATAFSGSSVG----------- 131
            :::|.||..|              .|::|   |.............:|...::|
Zfish   432 SSNSDSGIGNFLPEEKNNRVLLVDLGANP---SRHVPTGPWENPMGSFCQGAIGGLPPPPPPPPI 493

  Fly   132 -HHHLQHHHQ---HTHPHAPQQSQSQQPQPQHQLQQPHPAGAPSSATQSHHHGS--ISVSG---- 186
             |.:...|.|   |..||                  ||..|.|...:..|.:.|  :.|||
Zfish   494 SHRNGFRHEQFVDHPQPH------------------PHSHGDPPLLSGRHLNSSSRLDVSGLPSR 540

  Fly   187 ---SGGGLLGSSGGSGNQQQAIEKLSRPMAFDKMEMLVREMQDQEHGVPVRQQKMFLTSIPYAFM 248
               |..| ..::|.||.:.                :.|..::|...|....|:.       ||
Zfish   541 SHYSAHG-KKAAGASGQRW----------------LPVHVLRDWRQGHSSDQES-------YA-- 579

  Fly   249 GYDLIEWLMDRLQIEESEALNIANQLCLHGYFFPVNDSKTLTVKDDSSLYRFQTPYYWPWQHKAP 313
                          |.::..:.||  |           .||.                |...|.|
Zfish   580 --------------ESTDGWSSAN--C-----------STLP----------------PPMSKIP 601

  Fly   314 -DNVEYAIYLAKRSLRNKQRHALEDYEAEALASLHKNLKGKWDFISMQAEEQVRLAKE-RKKGDK 376
             |....|..:|.:..|   .||.:|..|:.|.. .|||:.     ..|....||.||: .|||.:
Zfish   602 ADRYRAAGEIASQPHR---LHAQKDEWAKKLFG-EKNLRE-----HSQQSNNVRRAKDSEKKGGR 657

  Fly   377 IVGDSQERAYWRVHRPPPGQFTPLEPCPVPSRDRQGLKPNKK----KTVDDMQRDVDYLGKSLNR 437
            ..|.:.                   ..|..|..|:....:|:    :::||::......|: ||.
Zfish   658 FKGITM-------------------GFPQRSSGRRSFGRSKRLSMARSLDDLESAAVSDGE-LNS 702

  Fly   438 TRMKMSQACESLVCYSETFSEYDFFLQPALPSNPWVTEDIAFWQLNNTFVDIP--------TEKR 494
            ..:|...:..||                                  |:...:|        ||:|
Zfish   703 VDLKGCGSDNSL----------------------------------NSNASLPSVQCHRRHTERR 733

  Fly   495 VKRWAISIEELVSDPTGLQEFTGFLEKEYSHENIRFWIA---VNRLRRSAHSQVARKVNEIYEEF 556
            |..||:..|.|:.||.|::.|:.||:||:|.|||.||.|   .:.:..:...|::::..|||..|
Zfish   734 VASWAVCFERLLQDPVGVRYFSEFLKKEFSEENILFWQACEYFSHVPETDKKQLSQRAREIYNSF 798

  Fly   557 LKPGAPCEINIDGKTM--ESVLKGLKNPSRFTFDSASEHIYMLLLKKDCYPRFIRSEHYKRLLDT 619
            |...|...:|||.:..  :.:|..   |....|......|:. |:|.|.|.||::|..|:..:..
Zfish   799 LSSKATTPVNIDSQAQLADDILNA---PRPDMFKEQQLQIFN-LMKFDSYTRFLKSYLYQECMLA 859

  Fly   620 GIQ----------PSYKKRFFNFGGVSGAKKKMTAA----LSSQPNLGDAAKGPSGTSAGS---- 666
            .::          ||           |...|..|.:    ||:...:.|..|..||.|...
Zfish   860 EVEGRPLPDPYQVPS-----------SPTSKHSTGSDRSNLSTPKKVQDDKKSKSGRSLNEDSRD 913

  Fly   667 -------------SMMQAPPPGNLAR------------RRGSDRSL-TGSAHELAVIGVNKDAGS 705
                         |..::...|:..|            ||.|..|| :|::.|||..|..|:.|.
Zfish   914 EHGDKKKSIFFSWSRNRSFGKGSKKRDLADYSFTGSNGRRESQGSLSSGASLELATSGSGKNEGE 978

  Fly   706 KVPHS---------HSQSNLSE-----IPF----SSDSIYRGDMPQRHMAIMDIGIYAAYGNR-- 750
            ...:|         |...||.:     :|.    |...:..|...:..:.:..:.::...|.:
Zfish   979 VSRNSMSLSERAVRHCNINLPDGSCCSVPIRPGVSIREVLLGLCEKLGINLAAVDLFLVGGEKPL 1043

  Fly   751 -----------------ESSLQALPETPKTKTTVLDATESTSSSTALAAAASSAVCPWDDPAESV 798
                             :.:|..|...|..::..|.|..:...:..|....:.......|...::
Zfish  1044 VLDQDCMTLCSRDLRLEKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGLNLGDLVATI 1108

  Fly   799 PPPPPPAQVKLSVCPWELDSATETPTAAPAVGSGGGGAGASKILSST--GQPMRLNSTSSDNSD- 860
            .....|..:.|.:.  .||.......|    |....|....|::||.  |.|:...|.|:...|
Zfish  1109 SGEKEPLDLGLPIS--NLDGLRVVLEA----GDHVSGKDKQKLVSSKSHGPPLSTRSQSATGEDK 1167

  Fly   861 -------------VNDRMQRNLGIRHQNTVDSGEAG---IKRLIPNIPEQRRASVSFTPSPTPDF 909
                         |..|.|:.|.|      |..|..   |.:...|..:.:|..::.:....|||
Zfish  1168 TAGKASAVKTRAQVEKRKQKKLNI------DEAEEFFELISKAQSNRADDQRGLLNKSDLVLPDF 1226

  Fly   910 QLGRTPTTTSSPTVAPSSSTPLQARSAVYGSGQGIAKDPPSGSDVDAELE-EELNKISLGES--- 970
            .  |..|......:   ||||:..::.        .:...:||.:.|..: :.|:....|::
Zfish  1227 L--RLDTEADGNNL---SSTPISHKTR--------PRSKENGSALSASHQTQSLDSAGEGKAPRR 1278

  Fly   971 SISEPPLLVVPTPEQTPPPITKITPPPGESENQADQVIDSTEIPGSSCST--------QANQFGE 1027
            ::..|...:..|..:.|||.:....|           |..:::.|||..|        ||.:..|
Zfish  1279 ALMPPNSALRNTSSRIPPPFSSSLSP-----------IPHSQMGGSSGITDWRSDGGVQALEEEE 1332

  Fly  1028 ATATVTTVKEVQIELIEQVSGVQTEPDSPPTIKVLVLEATTPV--SAETATADPGENLAKMATAS 1090
            :...:|.|.|..|          |.|:|.     |:.::..|:  |.|.:      :|.|..|..
Zfish  1333 SGMDLTFVAEGDI----------TSPNSS-----LLHQSPIPLPPSPERS------HLLKEDTCQ 1376

  Fly  1091 NTTTITTDDQAMRADDDAERAAEIEQTVLDELSPTTDEYQEFGDAKDAVDDFDSIDIG-----YI 1150
                          |..|.....:.:||:...:       .|...|:.....|...:.     ..
Zfish  1377 --------------DSWARSGGLMTKTVVSNRN-------RFSSVKNERRQRDRTSVSKYSHRRA 1420

  Fly  1151 PPAPTPAPSMAPLAELDVDTVDDEPCEPAAPPPSHSAPASSSSRELVMASGSVTATPTSSNEEAR 1215
            |.||.|.|...|            |..|:|||....|    ..|..:...|::........:...
Zfish  1421 PSAPPPPPPHPP------------PAPPSAPPRVRGA----GKRSPLHVRGALDVDGIHCGDLGG 1469

  Fly  1216 KRRKKRNSEGKKLSSQDDKDKDAHERAG-------------GSSMDAADHNAVCP-----WEDEN 1262
            ..|:   |||.:....|.|......|.|             ...:|.....::.|     .:..|
Zfish  1470 DNRE---SEGLERVVGDLKTSKGRMRTGVYQTSDQAELLPTKKRIDPVAKKSIKPSVKTSSKKSN 1531

  Fly  1263 VSTNDGTFV 1271
            .|.|:.|||
Zfish  1532 HSKNNATFV 1540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42450	NP_001259691.1	DEP_RGS7-like	219..306	CDD:239897	12/86 (14%)
		RGS_DHEX	303..401	CDD:375589	24/99 (24%)
		G-gamma	418..482	CDD:459879	8/67 (12%)
		RGS_R7-like	494..614	CDD:188660	42/124 (34%)
rgs12b	NP_999889.1	PDZ_RGS12-like	21..96	CDD:467194
		PTB_RGS12	239..372	CDD:269984
		RGS_RGS12	741..855	CDD:188696	39/117 (33%)
		RGS12_us1	861..973	CDD:465199	25/122 (20%)
		RBD1_RGS12	992..1061	CDD:340656	7/68 (10%)
		RBD2_RGS12	1062..1134	CDD:340658	12/77 (16%)
		RGS12_us2	1136..1193	CDD:435461	14/62 (23%)
		GoLoco	1195..1216	CDD:214645	4/20 (20%)
		RGS12_usC	<1323..1374	CDD:465198	16/71 (23%)