Protein Alignment CG42450 and Rgs9

DIOPT Version :10

• Sequence 1: NP_001259691.1
• Gene: CG42450 / 32874
• FlyBaseID: FBgn0259927
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: NP_035398.2
• Gene: Rgs9 / 19739
• MGIID: 1338824
• Length: 675
• Species: Mus musculus
• Alignment Length: 708
• Identity: 251/708 - (35%)
• Similarity: 354/708 - (50%)
• Gaps: 98/708 - (13%)

  Fly   210 RP-MAF-DKMEMLVREMQDQEHGVPVRQQKMFLTSIPYAFMGYDLIEWLMDRLQIEESEALNIAN 272
            || ||| .|:|.||::||:.|.||.:..|::.:||:|:|..|.|:::|:..||.|...||.|:.|
Mouse    11 RPRMAFLQKIEALVKDMQNPETGVRMHNQRVLVTSVPHAMTGGDVLQWITQRLWISNLEAQNLGN 75

  Fly   273 QLCLHGYFFPVNDSKTLTVKDDSSLYRFQTPYYWPWQHKAPDNVEYAIYLAKRSLRNKQRHALED 337
            .:..:||.:|:.|.|.|.:|.|||||||||||:||.|....::.:||||||||::  |::..||:
Mouse    76 FIVKYGYIYPLQDPKNLILKPDSSLYRFQTPYFWPTQQWPAEDTDYAIYLAKRNI--KKKGILEE 138

  Fly   338 YEAEALASLHKNLKGKWDFISMQAEEQVRLAKERKKGDKIVGDSQERAYWRVHRPPPGQFTPLEP 402
            ||.|....|:|.:..||||:.|||:||.|..|||.|.|:...|.||:|||.|||.|||....|:
Mouse   139 YEKENYDFLNKKINYKWDFVIMQAKEQYRTGKERNKADRYALDCQEKAYWLVHRSPPGMNNVLD- 202

  Fly   403 CPVPSRDRQGL----KPN--KKKTVDDMQRDVDYLGKSLNRTRMKMSQACESLVCYSETFSEYDF 461
                    .||    .||  ||:||..:::::.|..::|.|:.:|.|.:...:|.|||.||..|.
Mouse   203 --------YGLDRVTNPNEVKKQTVTAVRKEIMYYQQALMRSTVKSSVSLGGIVKYSEQFSSNDA 259

  Fly   462 FLQPALPSNPWVTEDIAFWQLNNTFVDIPTEKRVKRWAISIEELVSDPTGLQEFTGFLEKEYSHE 526
            .:...||||||:|:|..||.||...|:|||:.||:|||.:..||:.||.|.|.|..||:||:|.|
Mouse   260 IMSGCLPSNPWITDDTQFWDLNAKLVEIPTKMRVERWAFNFSELIRDPKGRQSFQYFLKKEFSGE 324

  Fly   527 NIRFWIAVNRLRRSAHSQVARKVNEIYEEFLKPGAPCEINIDGKTMESVLKGLKNPSRFTFDSAS 591
            |:.||.|...|:....|:|..|..|||:.||.|||...||||||||:..:|||::|.|:..|:|.
Mouse   325 NLGFWEACEDLKYGDQSKVKEKAEEIYKLFLAPGARRWINIDGKTMDITVKGLRHPHRYVLDAAQ 389

  Fly   592 EHIYMLLLKKDCYPRFIRSEHYKRLLDTGIQPS----------YKKRFFNFGGVSGAKKKMTAAL 646
            .|||| |:|||.|.|:::|..||.:|...|:|.          :.:|...    |.....:...|
Mouse   390 THIYM-LMKKDSYARYLKSPIYKEMLAKAIEPQETTKRSSTLPFMRRHLR----SSPSPVILRQL 449

  Fly   647 SSQPNLGDAAKGPSGTSAGSSMMQAPPPGNLARRRGSDRSLTGSAHELAVIGVNKDAGSKVPHSH 711
            ..:....:||.....|..|..:  ||.|                  .|||.     .|:.||.|.
Mouse   450 EEEEKAREAANTVDITQPGQHL--APSP------------------HLAVY-----TGTCVPPSP 489

  Fly   712 SQSNLSEIPFSSDSIYRGDMPQRHMAIMDIGIYAAYGNRESSLQALPETPKTKTTVLDATESTSS 776
            |.      |||...    ..|::..|.....|      |..|:...|...:.........|....
Mouse   490 SS------PFSPSC----RSPRKPFASPSRFI------RRPSIAICPSPSRVALEGSSGLEPKGE 538

  Fly   777 STALAAAASSAVC----PWDDPAESVPPPPPPAQVKLSVCPWELDSATETPTAA------PAVGS 831
            ::...|.:..:|.    |..|.:...|..||.|:..||:..:.......:|..|      |:|..
Mouse   539 ASWSGANSGPSVTENREPSADHSRPQPRAPPKARAALSLGRFLRRGCLASPVFARLSPKCPSVSH 603

  Fly   832 GGGGAGASKI--LSSTGQPM-RLNSTSSDN-SDVNDRMQRNLGIRHQNTVD--SGEAG 883
            |       |:  |...||.: ||......| ..:...|..:.|....::.|  :||:|
Mouse   604 G-------KVQPLGDMGQQLPRLKPKKVANFFQIKMEMPTDSGTCLMDSDDPRAGESG 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42450	NP_001259691.1	DEP_RGS7-like	219..306	CDD:239897	40/86 (47%)
		RGS_DHEX	303..401	CDD:375589	48/97 (49%)
		G-gamma	418..482	CDD:459879	25/63 (40%)
		RGS_R7-like	494..614	CDD:188660	60/119 (50%)
Rgs9	NP_035398.2	DEP_RGS7-like	22..109	CDD:239897	40/86 (47%)
		RGS_DHEX	106..205	CDD:375589	49/109 (45%)
		GGL	219..280	CDD:128520	23/60 (38%)
		RGS_RGS9	292..412	CDD:188693	61/120 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	524..571		8/46 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	637..662		5/18 (28%)