Protein Alignment CG42450 and rgs-6

DIOPT Version :10

• Sequence 1: NP_001259691.1
• Gene: CG42450 / 32874
• FlyBaseID: FBgn0259927
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: NP_001294820.1
• Gene: rgs-6 / 180840
• WormBaseID: WBGene00004349
• Length: 734
• Species: Caenorhabditis elegans
• Alignment Length: 799
• Identity: 152/799 - (19%)
• Similarity: 246/799 - (30%)
• Gaps: 264/799 - (33%)

  Fly   464 QPALPSNPWVTEDIAFWQLNNTFVDIPTEKRVKRWAISIEELVSDPTGLQEFTGFLEKEYSHENI 528
            :||.|:|.....:.:...|:........|....|.....::::.||.....|..|||:::..||:
 Worm     9 EPATPTNTSPNNETSNSCLSMGVGVASNETNSSRELKIFKKVIRDPVLRAPFQEFLEQQFCAENL 73

  Fly   529 RFWIAVNRLRR----SAHSQVARKVNEIYEEFLKPGAPCEINIDGKTMESVLKGLKNPSRF---T 586
            .|::||.:.:.    ...|...|:   |::.:....:...:|||..|.:.:.:.::: ..|   |
 Worm    74 NFYLAVEQFKEIQDFQERSSFGRR---IFDRYFAMNSTEPVNIDNSTSKRIRETVES-GGFPLDT 134

  Fly   587 FDSASEHIYMLLLKKDCYPRFIRSEHYKRLLDTGIQPSY-----------KKRFFNFGGVSGAKK 640
            :|.|...| :.|||.||:|||:||.:       ..|||:           |........::...:
 Worm   135 YDVAQYQI-LHLLKYDCWPRFLRSTN-------NSQPSFTDEELAADDEDKNGHSQPTSLNNTNE 191

  Fly   641 KMTAALSSQPNLGDAAKGPSGTSAGSSMMQAPP-------------PGNLARRRGSDRSLTGSAH 692
            ...||..|||    |...|:.|....|...:.|             |.:|.|.|
 Worm   192 FEAAAQQSQP----APNAPAATKEKPSKQYSMPAEMTSPVKKNSLSPTHLRRCR----------- 241

  Fly   693 ELAVIGVNKDAGSKVPHSHSQSNLSEIPFSSDSIYRGD-----------------MPQRHMAIMD 740
                         .|...|.|..:.: .|:::::...|                 |.:.|:.::|
 Worm   242 -------------PVEPKHCQLMIGD-QFNTETVTLSDPTMSVRRWTQEMADAQGMDRMHVEVVD 292

  Fly   741 IGIYAAYGNRESSLQAL--------------------------PETPKTKTTVLDATESTSSSTA 779
            ....:.......::.||                          |.:..||...:.|..|.|:...
 Worm   293 AETGSTIDPARQAIDALQSRALRLVPVVSFIIEFLPANFSFKNPASTPTKLVCIRARHSLSTGAV 357

  Fly   780 L-----------------------------AAAASSAVC-------PWDDPAESVPPPPPPAQVK 808
            |                             |....|..|       .:.|...:.....||....
 Worm   358 LRPLLHKYTLDPQVTRIVLNGSLEQVKRSCAVGQVSQKCLTVMSEAQYSDRVNAGKVSLPPRDPI 422

  Fly   809 LSVCPWELDSATETPTAAPAVGSGGGGAGASKILSSTGQPMRLNSTSSDNSDVNDRMQRNLGIRH 873
            ||..|                         |.|......|...|...| ..::.:..:||   :|
 Worm   423 LSQLP-------------------------STIYEQNNFPFHQNGDIS-YCEIPNESERN---KH 458

  Fly   874 QNTVDSGEAGIKRLIPNIPEQ-------------RRASVSFTPS-PTPDFQLGRTPTTTSSPTVA 924
            .:....|        ||...|             |:||.:.:.| |.|  ..|.:....:|...:
 Worm   459 AHLQHDG--------PNAAHQQKEYTLSIFNKFVRKASHAVSKSDPNP--SAGTSQDRMASGVYS 513

  Fly   925 PSSSTPLQARSAVYGSG-QGIAKDPPSGSDVDAE---LEEELNKISL----GESSISEP------ 975
            |::..|..|..|..|:. .|.|....:||...:.   .|...|::|:    .|..:.:|
 Worm   514 PATGGPSFASRAAAGTNFGGSANQVNAGSASTSSNNVSEPSKNRLSIFKSKTEKKVVKPESEKEK 578

  Fly   976 --------PLLVVPTP--EQTPPPITKITPPP-------GESENQADQ-----VIDSTEI----- 1013
                    |.....||  .:|.|..::.|..|       |:..:|..|     .|.||:|
 Worm   579 LKPRSDDIPTTSTSTPMAVETKPNGSRTTEEPLKRMGKSGDDGSQEPQGIRHPAIFSTKIGDEAA 643

  Fly  1014 ---PGSSCSTQANQFGEATATVTTVKEVQIELIEQVSGVQTEPDSPPTIKVLVLEATTPVSAETA 1075
               .|:|.||.|.....:..|.||                |.|...||...:....||..:..:.
 Worm   644 AAAAGASPSTSAPSTSTSVQTKTT----------------TSPTKSPTSTTITTSGTTTSATSSV 692

  Fly  1076 TADPGENLAKMATASNTTT 1094
            ...|...|..|.:||...|
 Worm   693 ATAPPPVLHAMRSASTPAT 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42450	NP_001259691.1	DEP_RGS7-like	219..306	CDD:239897
		RGS_DHEX	303..401	CDD:375589
		G-gamma	418..482	CDD:459879	4/17 (24%)
		RGS_R7-like	494..614	CDD:188660	34/126 (27%)
rgs-6	NP_001294820.1	RGS	47..157	CDD:214613	31/114 (27%)