DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42450 and Axin2

DIOPT Version :10

Sequence 1:NP_001259691.1 Gene:CG42450 / 32874 FlyBaseID:FBgn0259927 Length:1280 Species:Drosophila melanogaster
Sequence 2:NP_056547.3 Gene:Axin2 / 12006 MGIID:1270862 Length:840 Species:Mus musculus


Alignment Length:975 Identity:191/975 - (19%)
Similarity:313/975 - (32%) Gaps:275/975 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   391 RPP-PGQFTPLEPCPVPSRDRQGLKPNKKKTVDDMQRDVDYLGKSLNRTRMKMSQACESLVCYSE 454
            ||| ||:.....||.......|..||  .....:.:|:.|.||:...|                 
Mouse    23 RPPVPGEEGETPPCQPSVGKVQSTKP--MPVSSNARRNEDGLGEPEGR----------------- 68

  Fly   455 TFSEYDFFLQPALPSNPWVTEDIAFWQLNNTFVDIPTEKRVKRWAISIEELVSDPTGLQEFTGFL 519
                       |.|.:|                       :.||..|:..|:.|..|...|..||
Mouse    69 -----------ASPDSP-----------------------LTRWTKSLHSLLGDQDGAYLFRTFL 99

  Fly   520 EKEYSHENIRFWIAVNRLRRS--AHSQVARKVNEIYEEFLKPGAPCEINIDGKTMESVLKGLKNP 582
            |:|...:.:.||.|.|..|:.  ..::..|....||:.:::..:.....:...|...:..|:|..
Mouse   100 EREKCVDTLDFWFACNGFRQMNLKDTKTLRVAKAIYKRYIENNSVVSKQLKPATKTYIRDGIKKQ 164

  Fly   583 --SRFTFDSA--------SEHIYMLLLKKDCYPRFIRSEHYKRLLDTGIQPSYKKRFFNFGGVSG 637
              ....||.|        .|:.|.:.|..|.|..::||        .|...:|...    ||: |
Mouse   165 QIGSVMFDQAQTEIQAVMEENAYQVFLTSDIYLEYVRS--------GGENTAYMSN----GGL-G 216

  Fly   638 AKKKMTAALSSQPNLGDAAK----------GPSGTSAGSSMMQAPPPGNLARRRGSDRSLTGSAH 692
            :.|.:...|   |.|.:..:          .|:.....|..::|     .|..|.::.:..|...
Mouse   217 SLKVLCGYL---PTLNEEEEWTCADLKCKLSPTVVGLSSKTLRA-----TASVRSTETAENGFRS 273

  Fly   693 ELAVIGVNK-DAGSKVPHSHSQS-NLSEIPFSSDSIYRGDMPQRHMAIMDIGIY----------- 744
            ......||. ..||....:.:.| |.||:  |||::....|.....::..:..|           
Mouse   274 FKRSDPVNPYHVGSGYVFAPATSANDSEL--SSDALTDDSMSMTDSSVDGVPPYRMGSKKQLQRE 336

  Fly   745 ---AAYGNRESSLQALPET---PKTKTTVLDATESTSSSTALAAAASSAVCPWDDPAESVPPPPP 803
               :...|.:.||...|.|   ||..|.|..|        |.||...|.:               
Mouse   337 MHRSVKANGQVSLPHFPRTHRLPKEMTPVEPA--------AFAAELISRL--------------- 378

  Fly   804 PAQVKLSVCPWELDSATETPTAAPAVGSGGGGAGASKILSS-----TGQPMRLNSTSSDNSD--- 860
             .::||     ||:|..........:.......|:.:.|||     ...|:.|..:.|...|   
Mouse   379 -EKLKL-----ELESRHSLEERLQQIREDEEKEGSEQALSSRDGAPVQHPLALLPSGSYEEDPQT 437

  Fly   861 -VNDRMQRNLGIRHQNTVDSGEAGIKRLIPNIPEQRRASVSFTPSPTPDFQL------------- 911
             ::|.:.|.|     .|......|:.|..|.             |.:||...             
Mouse   438 ILDDHLSRVL-----KTPGCQSPGVGRYSPR-------------SRSPDHHHQHHHHQQCHTLLP 484

  Fly   912 --GRTPTTTSSPTVAPSSSTPLQARSAVYGSGQGIAKDPPSGSDVDAELEEELNKISLG------ 968
              |:.|...:.|.:...|....|....|:.........|.:..:::||..:.:..:..|      
Mouse   485 TGGKLPPVAACPLLGGKSFLTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVRCLCPGGTDYYC 549

  Fly   969 ESSISEPPLLVVPTP-EQ-------TPPPITKITPPPGESENQADQVIDST----EIPGSSCSTQ 1021
            .|.....|....|.| ||       |.|........||.:.:..|..:.|.    ::||..    
Mouse   550 YSKCKSHPKAPEPLPGEQFCGSRGGTLPKRNAKGTEPGLALSARDGGMSSAAGAPQLPGEE---- 610

  Fly  1022 ANQFGEATATVTTVKEVQIELIEQVSGVQTEPDSPPTIKVLVLEATTPVSAETATADPGENLAK- 1085
                |:.:      ::|...::|.....:::|.|..:|:     .:.|:  |:|.|.|||.::: 
Mouse   611 ----GDRS------QDVWQWMLESERQSKSKPHSAQSIR-----KSYPL--ESACAAPGERVSRH 658

  Fly  1086 --MATASNTTTIT-----TDDQAMRADDDAERAAEIEQTVLDELSPTTDEYQEFGDAKDAVDDFD 1143
              :..:.::.::.     |.|.||.........|::|:........:..:.|....|....|...
Mouse   659 HLLGASGHSRSVARAHPFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPQKQRCCVASQQRDRNH 723

  Fly  1144 SIDIGYIPPAPTPAPSMAPLAELDVDTVDDEPCEPAAPPPSHSAPASSSSRELVMASGSVTATPT 1208
            |. .|....:|...||:||          ::..||......|:..||    |||:       |..
Mouse   724 SA-AGQAGASPFANPSLAP----------EDHKEPKKLASVHALQAS----ELVV-------TYF 766

  Fly  1209 SSNEEARKRRKKRNSE------GKKLSSQDDK----DKDAHERAGGSSMDAADHNAVCPWEDENV 1263
            ...||...||..:...      .::||.:.:.    .|.:.|.|.|:..:..       |:||.|
Mouse   767 FCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEI-------WDDETV 824

  Fly  1264  1263
            Mouse   825  824

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42450NP_001259691.1 DEP_RGS7-like 219..306 CDD:239897
RGS_DHEX 303..401 CDD:375589 5/10 (50%)
G-gamma 418..482 CDD:459879 8/63 (13%)
RGS_R7-like 494..614 CDD:188660 32/131 (24%)
Axin2NP_056547.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..75 18/104 (17%)
AXIN1_TNKS_BD 10..75 CDD:465215 18/104 (17%)
Tankyrase-binding motif 21..30 5/6 (83%)
RGS_Axin 82..198 CDD:188662 27/115 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 300..363 14/64 (22%)
Interaction with GSK3B. /evidence=ECO:0000250 327..413 21/114 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..435 7/36 (19%)
Interaction with beta-catenin. /evidence=ECO:0000250 413..478 15/82 (18%)
Axin_b-cat_bind 433..468 CDD:462616 9/52 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 447..485 8/55 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 572..614 9/49 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 715..745 9/40 (23%)
DAX 758..840 CDD:197474 20/85 (24%)
Blue background indicates that the domain is not in the aligned region.

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