Protein Alignment CG7058 and SPOP

DIOPT Version :9

• Sequence 1: NP_573327.2
• Gene: CG7058 / 32873
• FlyBaseID: FBgn0030961
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_001007227.1
• Gene: SPOP / 8405
• HGNCID: 11254
• Length: 374
• Species: Homo sapiens
• Alignment Length: 437
• Identity: 93/437 - (21%)
• Similarity: 158/437 - (36%)
• Gaps: 145/437 - (33%)

  Fly   662 TFC--EMDFLSKSSTINQNLEQLIMDIPAYIFIVENLSDRLDDKLGW------------------ 706
            :||  ||..:.||||                     .|...:|||.|
Human    42 SFCREEMGEVIKSST---------------------FSSGANDKLKWCLRVNPKGLDEESKDYLS 85

  Fly   707 ----------KEFKFCFKLATSQINGVIAKLLEHKDALRDAISQICMLVRKQE--FTQSVIELGL 759
                      .|.:..||.:.....|...|.:|.:.|.|        .|:.::  |.:.:....|
Human    86 LYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYR--------FVQGKDWGFKKFIRRDFL 142

  Fly   760 LDDTCLLSNNLKMADHENNLNQGLSEKDSMYLDRKQYYDYNSIKLNLIRHLCEPPIAASS-NLS- 822
            ||:.                 .||...|.:.|                  .||..:...| |:|
Human   143 LDEA-----------------NGLLPDDKLTL------------------FCEVSVVQDSVNISG 172

  Fly   823 KNALRLLH--STQLADMEFEVHTYAPTSGAAKSGGGTEAVPETAEPAAKVLQVHSFKAHRVIVAA 885
            :|.:.::.  ..:|||               :.||..|....|  .....:....|:||:.|:||
Human   173 QNTMNMVKVPECRLAD---------------ELGGLWENSRFT--DCCLCVAGQEFQAHKAILAA 220

  Fly   886 RCEWFKKALMSGMQESINRKVIITDTSPVIFRRLLLYLY--GAP-IDRTVGAEQVCELMLLADRY 947
            |...|.......|:||...:|.|.|..|.:|:.::.::|  .|| :|:...     :|:..||:|
Human   221 RSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMAD-----DLLAAADKY 280

  Fly   948 SIDDLKELCENTLYSLIDEDSVVCLLGIADRYMATALKSKCLSFLSQHAQLTKCEIFKELPQTLQ 1012
            :::.||.:||:.|.|.:..::...:|.:||.:.|..||::.:.|::.||.
Human   281 ALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHAS--------------- 330

  Fly  1013 LEVMDLIHWFGR-VSEP-WNDRGFKPRSSSRHSLKSPSKPRSRSRKS 1057
             :|::...|... ||.| .....::..:|::.....|  ||.|.::|
Human   331 -DVLETSGWKSMVVSHPHLVAEAYRSLASAQCPFLGP--PRKRLKQS 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7058	NP_573327.2	BTB	870..964	CDD:197585	30/96 (31%)
		BTB	870..960	CDD:279045	28/92 (30%)
		SPOP_C_like	964..1016	CDD:269810	9/51 (18%)
SPOP	NP_001007227.1	MATH_SPOP	28..166	CDD:239743	32/187 (17%)
		Required for nuclear localization	71..191		26/177 (15%)
		Important for binding substrate proteins	123..133		2/17 (12%)
		BTB_POZ_SPOP-like	182..301	CDD:349588	37/140 (26%)
		Important for homodimerization	186..217		10/47 (21%)
		BACK_SPOP	297..367	CDD:350593	16/87 (18%)
		Important for homodimerization	297..355		14/73 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1987
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810