DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7058 and SPOPL

DIOPT Version :9

Sequence 1:	NP_573327.2	Gene:	CG7058 / 32873	FlyBaseID:	FBgn0030961	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001001664.1	Gene:	SPOPL / 339745	HGNCID:	27934	Length:	392	Species:	Homo sapiens

Alignment Length:	380	Identity:	85/380 - (22%)
Similarity:	147/380 - (38%)	Gaps:	121/380 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   662 TFC--EMDFLSKSSTINQNLEQLIMDIPAYIFIVENLSDRLDDKLGWKEFKFCFKLATSQINGVI 724
            :||  ||..:.||||.:..        |:             ||:.|     |.::....::
Human    42 SFCREEMGEVLKSSTFSSG--------PS-------------DKMKW-----CLRVNPKGLD--- 77

  Fly   725 AKLLEHKDALRDAISQICMLVR--KQEFTQSVIELGLLDDTCLLSNNLKMADHENNLNQG----L 783
                   |..:|.:|...:||.  |.| .::..:..||        |.|..:.:...:|.    :
Human    78 -------DESKDYLSLYLLLVSCPKSE-VRAKFKFSLL--------NAKREETKAMESQRAYRFV 126

  Fly   784 SEKD---SMYLDRKQYYD-YNSI----KLNLIRHLCEPPIAASS-NLS----KNALR-------- 827
            ..||   ..::.|....| .|.:    ||.|   .||..:...| |:|    .|.|:
Human   127 QGKDWGFKKFIRRDFLLDEANGLLPDDKLTL---FCEVSVVQDSVNISGHTNTNTLKVPECRLAE 188

  Fly   828 ----LLHSTQLADMEFEVHTYAPTSGAAKSGGGTEAVPETAEPAAKVLQVHSFKAHRVIVAARCE 888
                |..:|:..|..|.|.             |.|                 ||||:.::|||..
Human   189 DLGNLWENTRFTDCSFFVR-------------GQE-----------------FKAHKSVLAARSP 223

  Fly   889 WFKKALMSGMQESINRKVIITDTSPVIFRRLLLYLYGAPIDRTVGAEQVCE-LMLLADRYSIDDL 952
            .|.......|:||...:|.|.|..|.:|:.::.::|   ..|....:::.: |:..||:|:::.|
Human   224 VFNAMFEHEMEESKKNRVEINDLDPEVFKEMMRFIY---TGRAPNLDKMADNLLAAADKYALERL 285

  Fly   953 KELCENTLYSLIDEDSVVCLLGIADRYMATALKSKCLSFLSQHAQLTKCEIFKEL 1007
            |.:||..|.|.:..::|...|.:||.:.|..||::.:.|::      :|.:.::|
Human   286 KVMCEEALCSNLSVENVADTLVLADLHSAEQLKAQAIDFIN------RCSVLRQL 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7058	NP_573327.2	BTB	870..964	CDD:197585	28/94 (30%)
		BTB	870..960	CDD:279045	26/90 (29%)
		SPOP_C_like	964..1016	CDD:269810	10/44 (23%)
SPOPL	NP_001001664.1	MATH	28..166	CDD:351761	35/171 (20%)
		BTB_POZ_SPOPL	179..301	CDD:349652	36/154 (23%)
		BACK_SPOPL	297..392	CDD:350594	10/44 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1987
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810