DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg101 and ATG101

DIOPT Version :9

Sequence 1:	NP_573326.1	Gene:	Atg101 / 32871	FlyBaseID:	FBgn0030960	Length:	218	Species:	Drosophila melanogaster
Sequence 2:	NP_001092143.1	Gene:	ATG101 / 60673	HGNCID:	25679	Length:	218	Species:	Homo sapiens

Alignment Length:	218	Identity:	111/218 - (50%)
Similarity:	156/218 - (71%)	Gaps:	0/218 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNARSQVFDLTMEGRQVDEAVATIFHTVLFHRCLGKYMYTGDAQYSIGTVGYTDVDCNFIDFTYV 65
            ||.||:|.::::|||||:||:..:.||||.||..||:.|..:..|||||||..||||:|||||||
Human     1 MNCRSEVLEVSVEGRQVEEAMLAVLHTVLLHRSTGKFHYKKEGTYSIGTVGTQDVDCDFIDFTYV 65

  Fly    66 CCTSDSLTHKVKRAINSFSEKLRSNESCGSGQISLEFFQKKKNRWPFPQESIPWEVWTVHLDLIK 130
            ..:|:.|...:::.:..|.:.||::...|.||:||||:||||:||||..|.||||||||.:.::.
Human    66 RVSSEELDRALRKVVGEFKDALRNSGGDGLGQMSLEFYQKKKSRWPFSDECIPWEVWTVKVHVVA 130

  Fly   131 HENEDERQLCRENVSDLLTEKVIYITELMNRHDYVPKTPSQSELDLIFDTSFPDVQPYLFKFDYS 195
            ...|.|||:|||.|.:.|.||:|.|.|:||||:|:||.|:|||:|.:|||...||||||:|..:.
Human   131 LATEQERQICREKVGEKLCEKIINIVEVMNRHEYLPKMPTQSEVDNVFDTGLRDVQPYLYKISFQ 195

  Fly   196 TSGSAAPSMGNAMKKIIKETLAM 218
            .:.:...|:...|:::||:|||:
Human   196 ITDALGTSVTTTMRRLIKDTLAL 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg101	NP_573326.1	ATG101	9..172	CDD:400281	85/162 (52%)
ATG101	NP_001092143.1	ATG101	9..172	CDD:400281	85/162 (52%)
ATG101	NP_001092143.1	Important for interaction with ATG13. /evidence=ECO:0000269\|PubMed:26299944	152..156		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146930
Domainoid	1	1.000	192	1.000	Domainoid score	I3239
eggNOG	1	0.900	-	-		E1_KOG4493
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11072
Inparanoid	1	1.050	245	1.000	Inparanoid score	I3288
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48336
OrthoDB	1	1.010	-	-		D1539728at2759
OrthoFinder	1	1.000	-	-		FOG0005798
OrthoInspector	1	1.000	-	-		oto89747
orthoMCL	1	0.900	-	-		OOG6_104431
Panther	1	1.100	-	-	LDO	PTHR13292
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R775
SonicParanoid	1	1.000	-	-		X5518
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800