DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6961 and Poldip3

DIOPT Version :9

Sequence 1:	NP_573325.1	Gene:	CG6961 / 32869	FlyBaseID:	FBgn0030959	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_848742.1	Gene:	Poldip3 / 73826	MGIID:	1921076	Length:	420	Species:	Mus musculus

Alignment Length:	519	Identity:	129/519 - (24%)
Similarity:	191/519 - (36%)	Gaps:	166/519 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DLSLDEIIERK----RGQRGYRPLDRKFNANFSKPRQLLNKPFFKPSGARGSHSDMPAKRTFDAR 64
            ||||||:|.::    :|:...||......:.......|:|:|      ||.:    ..::.||||
Mouse     3 DLSLDELIRKRGTAAKGRLSVRPGIGGVRSRVGIQHSLVNQP------ARTA----TFQQRFDAR 57

  Fly    65 NTIA---AKTRAKIADARD-LINKS----VRDSGIDARQLLLERKKARSA--GPILIDDEEESFE 119
            ..|.   |:.:..:.|||: |:.|.    ::....|||::|..||:..:.  .|..:.|..|...
Mouse    58 QKIGLSDARLKLGVKDAREKLLQKDARFRIKGKVQDAREMLNSRKQQGTVPQKPRQVADAREKIS 122

  Fly   120 PSHR--ARGKGVHIGQFGHRLSMSNHADGTIQAKWDSDDGVVELGNHMLSGLRRTFDPRSHKPGK 182
            ...|  |......||.....|.::.    |||.  .....:|.|..|. :|:|... ..:|:
Mouse   123 LKRRSPAAFTSPPIGTVTPALKLTK----TIQV--PQQKAMVPLHAHP-AGMRINV-VNNHQ--- 176

  Fly   183 PFAPRRYIDLDNMQDLEDEEISRTLHLGQMKQA---SPRYSIGGLDLNRGDDVEMSMA-PLNNKI 243
              |.:...|||     ||::|...:...|||.|   |..:.:.||..::   :.||.| ||...:
Mouse   177 --AKQNLYDLD-----EDDDIVVPVPPKQMKFAATGSLVHHMTGLSSSK---LSMSKALPLTKVV 231

  Fly   244 DNNAFSIYEAARNRIERPSLTNRLVVGRSNSTKEPLERRHRDTVSTSKLPESLR-------SRLF 301
            .|:|::                           .|:            ||.|:|       ||..
Mouse   232 QNDAYT---------------------------APV------------LPSSVRTKALTSMSRTL 257

  Fly   302 VGKRDPHISHGIYANENRRKAVGGGGGSDSDSGTDSDGDAAAPSKNKRRSP--SPLSLRTSNTKD 364
            |.|.:|                                    |.:.....|  |||        :
Mouse   258 VNKEEP------------------------------------PKELPPAEPVLSPL--------E 278

  Fly   365 GYRLLVSNLHTNVTTADIRELFSDIGPVYDARVVRPGTAEVIYKSLEHAEKAVDTYHHRQFDDQP 429
            |.::.|:|||..||..||.|||...|.:..||:|.||.|||::...:.|..|...|::|..|.||
Mouse   279 GTKMTVNNLHPRVTEEDIVELFCVCGALKRARLVHPGVAEVVFVKKDDAITAYKKYNNRCLDGQP 343

  Fly   430 MHCVLVNPH----------------SSRRSVHKASSRTVTTNSSG----VEVDIDALHSVLFRA 473
            |.|   |.|                |...||.|.|......|.:.    .|||.|.:...||::
Mouse   344 MKC---NLHMNGNVITSDQPILLRLSDSPSVKKESELPRRGNPASSNPPAEVDPDTVLRALFKS 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6961	NP_573325.1	RRM	256..>443	CDD:223796	48/211 (23%)
CG6961	NP_573325.1	RRM_SKAR	366..434	CDD:241125	29/67 (43%)
Poldip3	NP_848742.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..277		6/56 (11%)
		RRM_SKAR	280..348	CDD:241125	29/70 (41%)
		RRM	<284..406	CDD:223796	43/124 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	369..394		7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839250
Domainoid	1	1.000	53	1.000	Domainoid score	I11306
eggNOG	1	0.900	-	-		E1_KOG0533
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007107
OrthoInspector	1	1.000	-	-		otm43066
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11260
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.820