DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6961 and Poldip3

DIOPT Version :9

Sequence 1:	NP_573325.1	Gene:	CG6961 / 32869	FlyBaseID:	FBgn0030959	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001123978.1	Gene:	Poldip3 / 315170	RGDID:	1311073	Length:	420	Species:	Rattus norvegicus

Alignment Length:	508	Identity:	124/508 - (24%)
Similarity:	192/508 - (37%)	Gaps:	144/508 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DLSLDEIIERK----RGQRGYRPLDRKFNANFSKPRQLLNKPFFKPSGARGSHSDMPAKRTFDAR 64
            |:||||:|.::    :|:...||......:.......||::|      ||.:    ..::.||||
  Rat     3 DISLDELIRKRGTATKGRLSVRPGIGGVRSRVGIQHSLLSQP------ARTA----TFQQRFDAR 57

  Fly    65 NTIA---AKTRAKIADARD-LINKS----VRDSGIDARQLLLERKKARSA--GPILIDDEEESFE 119
            ..|.   |:.:..:.|||: |:.|.    ::....|||::|..||:..:.  .|..:.|..|...
  Rat    58 QKIGLSDARLKLGVKDAREKLLQKDARFRIKGKVQDAREMLNSRKQQNTVPQKPRQVADAREKIS 122

  Fly   120 PSHR--ARGKGVHIGQFGHRLSMSNHADGTIQAKWDSDDGVVELGNHMLSGLRRTFDPRSHKPGK 182
            ...|  |......||.....|.::.    |||.  .....:|.|..|. :|:|... ..:|:
  Rat   123 LKRRSPATFTSPPIGTVTPALKLTK----TIQV--PQQKAMVPLHAHP-AGMRINV-VNNHQ--- 176

  Fly   183 PFAPRRYIDLDNMQDLEDEEISRTLHLGQMKQASPRYSIGGLDLNRGDDVEMSMA-PLNNKIDNN 246
              |.:...|||     ||::|...:...|||.|:|...:..........:.||.. ||...:.|:
  Rat   177 --AKQNLYDLD-----EDDDIVAPVPTKQMKFAAPGSLVHHTTGMSSPKLSMSKTLPLTKVVQND 234

  Fly   247 AFSIYEAARNRIERPSLTNRLVVGRSNSTKEPLERRHRDTVSTSKLPESLRSRLFVGKRDPHISH 311
            |::. ....:.:...:|||   :.|:...||.|.:         :||.:          :|.:
  Rat   235 AYTA-PVLPSSVRTKALTN---MSRTLVNKEELPK---------ELPPA----------EPVL-- 274

  Fly   312 GIYANENRRKAVGGGGGSDSDSGTDSDGDAAAPSKNKRRSPSPLSLRTSNTKDGYRLLVSNLHTN 376
                                                     |||        :|.::.|:|||..
  Rat   275 -----------------------------------------SPL--------EGTKMTVNNLHPR 290

  Fly   377 VTTADIRELFSDIGPVYDARVVRPGTAEVIYKSLEHAEKAVDTYHHRQFDDQPMHCVLVNPH--- 438
            ||..||.|||...|.:..||:|.||.|||::...:.|..|...|::|..|.|||.|   |.|
  Rat   291 VTEEDIVELFCVCGALKRARLVHPGVAEVVFVKKDDAITAYKKYNNRCLDGQPMKC---NLHMNG 352

  Fly   439 -------------SSRRSVHKAS-----SRTVTTNSSGVEVDIDALHSVLFRA 473
                         |...||.|.|     ...|::|.. .|||.|.:...||::
  Rat   353 NVITSDQPILLRLSDSPSVKKESELPRRGNPVSSNPP-AEVDPDTILRALFKS 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6961	NP_573325.1	RRM	256..>443	CDD:223796	46/202 (23%)
CG6961	NP_573325.1	RRM_SKAR	366..434	CDD:241125	29/67 (43%)
Poldip3	NP_001123978.1	RRM	216..406	CDD:223796	64/267 (24%)
Poldip3	NP_001123978.1	RRM_SKAR	280..348	CDD:241125	29/70 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343054
Domainoid	1	1.000	53	1.000	Domainoid score	I11076
eggNOG	1	0.900	-	-		E1_KOG0533
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1462536at2759
OrthoFinder	1	1.000	-	-		FOG0007107
OrthoInspector	1	1.000	-	-		otm45131
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.800